{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:22:47Z","timestamp":1789705367387,"version":"4.0.1"},"reference-count":50,"publisher":"FapUNIFESP (SciELO)","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Latino-Am. Enfermagem"],"abstract":"<jats:p>ABSTRACT Objective: to evaluate the safety of a topical formulation containing chamomile microparticles coated with chitosan in the skin of healthy participants. Method: phase I blind, controlled, non-randomized, single-dose clinical trial with control for skin, base formulation, and formulation with microparticles. The variables analyzed were irritation and hydration by the Wilcoxon and Kruskall-Wallis tests. Results: the study started with 35 participants with a mean age of 26.3 years. Of these, 30 (85.71%) were female, 29 (82.90%) were white skinned and 32 (91.40%) had no previous pathologies. One participant was removed from the study reporting erythema at the site of application, and four other participants for not attending the last evaluation. In the 30 participants who completed the study, the tested formulation did not cause erythema, peeling, burning, pruritus or pain; there was an improvement in cutaneous hydration in the site of application of the formulation with microparticles. In the evaluation of the barrier function, there was an increase in transepidermal water loss in all sites. Conclusion: the formulation with chamomile microparticles is safe for topical use, not causing irritation and improving skin hydration over four weeks of use. Its effects on barrier function need further investigation. No. RBR-3h78kz in the Brazilian Registry of Clinical Trials (ReBEC).<\/jats:p>","DOI":"10.1590\/1518-8345.2648.3075","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T06:50:50Z","timestamp":1543560650000},"source":"Crossref","is-referenced-by-count":11,"title":["Safety of a formulation containing chitosan microparticles with chamomile: blind controlled clinical trial"],"prefix":"10.1590","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0516-5213","authenticated-orcid":false,"given":"Danielle Cristina","family":"Garbuio","sequence":"first","affiliation":[{"name":"Universidade Anhanguera, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Mara","family":"Zamarioli","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edsa Oliveira de","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Maria Berardo Gon\u00e7alves Maia","family":"Campos","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Em\u00edlia Campos de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Alexandre Pedro de","family":"Freitas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"570","DOI":"10.12968\/nrec.2012.14.11.570","article-title":"Our outermost boundary the skin","volume":"14","author":"Wheeler T","year":"2012","journal-title":"Nurs Residential Care"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.7748\/ns2012.09.27.3.35.c9299","article-title":"The integumentary system: anatomy, physiology and function of skin","volume":"27","author":"Mclafferty E","year":"2012","journal-title":"Nurs Stand"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.12968\/pnur.2013.24.1.30","article-title":"Skin rashes, part 1 Skin structure and taking a dermatological history","volume":"24","author":"Watkins J","year":"2013","journal-title":"Practice Nurs"},{"issue":"2","key":"ref4","first-page":"249","article-title":"Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds","volume":"10","author":"N\u00f3brega AT","year":"2013","journal-title":"Biomed Biopharm Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.taap.2017.01.009","article-title":"Identification of a compound isolated from German chamomile (Matricaria chamomilla) with dermal sensitization potential","volume":"318","author":"Avonto C","year":"2017","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref6","series-title":"Ag\u00eancia Nacional de Vigil\u00e2ncia Sanit\u00e1ria. 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