{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:55:36Z","timestamp":1772232936651,"version":"3.50.1"},"reference-count":61,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Latino-Am. Enfermagem"],"abstract":"<jats:p>Objective: to assess the clinical, inflammatory and electrocardiographic profile of cancer patients undergoing the Pre-chemotherapy phase, with the purpose of early identifying cardiovascular toxicity indicative signs.  Method: an observational and cross-sectional study, conducted between November2022 and December2023 with adult cancer patients in stagesI toIII treated at a hospital from southern Brazil. Sociodemographic, clinical and tumor-related data were collected, in addition to laboratory and electrocardiographic tests performed before the first chemotherapy infusion. Descriptive analyses were carried out in the Rsoftware.  Results: the participants were 84 patients, mostly women (72.6%) with breast cancer diagnoses(57.1%). Prevalence of systemic inflammation was verified, with high C-reactive protein in 35.7% and increased neutrophil-lymphocyte and platelet-lymphocyte ratios in 23.5% and 27.2%, respectively. A significant association was observed between high Body Mass Index and T-wave alterations (p=0.005). Although 10 patients presented prolonged corrected QT intervals, no other statistically significant associations were identified.  Conclusion: the pre-chemotherapy phase revealed relevant inflammatory and electrocardiographic alterations, even in the absence of installed cardiotoxicity. The findings reinforce the importance of baseline cardiovascular evaluations and of multi-professional follow-up in Cardio-Oncology, especially for patients with modifiable risk factors. Longitudinal studies are recommended to elucidate the clinical and prognostic evolution of these alterations.<\/jats:p>","DOI":"10.1590\/1518-8345.7472.4774","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T15:06:12Z","timestamp":1768575972000},"source":"Crossref","is-referenced-by-count":0,"title":["Chemotherapy-induced cardiotoxicity in cancer patients: an observational study at an Oncology reference hospital from southeastern Brazil"],"prefix":"10.1590","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8141-5880","authenticated-orcid":false,"given":"Karoline","family":"Neumann","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil; Scholarship holder at the Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3433-4925","authenticated-orcid":false,"given":"Karolini Zuqui","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-6031","authenticated-orcid":false,"given":"Wesley Rocha","family":"Grippa","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2070-6262","authenticated-orcid":false,"given":"Naira Santos","family":"D\u2019Agostini","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-325X","authenticated-orcid":false,"given":"Sara Isabel Pimentel de Carvalho","family":"Schuab","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2424-6510","authenticated-orcid":false,"given":"Lu\u00eds Carlos","family":"Lopes-J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil; Scholarship holder at the Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"68","key":"ref1","article-title":"Global Epidemiological Patterns in the Burden of Main Non-Communicable Diseases, 1990-2019: Relationships With Socio-Demographic Index","volume":"16","author":"Bai J.","year":"2023","journal-title":"Int J Public Health"},{"key":"ref2","series-title":"Cardiovascular diseases (CVDs)","year":"2020"},{"key":"ref3","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"18","key":"ref4","article-title":"The 2022 European Society of Cardiology Cardio-oncology Guidelines in Focus","volume":"21","author":"Gent D. 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