{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:33:44Z","timestamp":1772966024567,"version":"3.50.1"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Campomanesia phaea (Myrtaceae), popularly known as cambuci, is one of several species of plants producing comestible fruits, largely used in human nutrition. Despite its consumption and economic potential, limited scientific research is available on the Campomanesia, especially those related to its therapeutic benefits. It is reported by traditional medicine the use of the plant in the treatment of different disorders, such as cardiovascular and nervous system disturbances. So, the aim of this study was to carry out the pharmacological evaluation of the hydro-alcoholic extract (HAE) of Campomanesia fruits in rats by screening consisting of tests: a) neuropharmacological observation, b) test on the cardiovascular system. The HAE, prepared from the extraction of fruits with water\/ethanol, was concentrated and freeze-dried. Behavioral responses in rats were investigated in open field test and the cardiovascular actions were investigated by a register of indirect blood pressure and the register of spontaneous beating rate right atrium. The results revealed that HAE induced grooming, hypotension and bradycardia. So, this study identified an action on the central nervous system, represented by grooming, and a cardiovascular activity of Campomanesia. The hypotension, attributed in part to bradycardia, was not related to a cholinergic effect, discarding a possible cholinomimetic action of the plant that could justify both cardiovascular and central actions.<\/jats:p>","DOI":"10.1590\/1519-6984.217046","type":"journal-article","created":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T19:24:50Z","timestamp":1570044290000},"page":"601-606","source":"Crossref","is-referenced-by-count":3,"title":["Pharmacological evaluation of the hydro-alcoholic extract of Campomanesia phaea fruits in rats"],"prefix":"10.1590","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5855-5952","authenticated-orcid":false,"given":"L. R.","family":"Wczassek","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1897-6023","authenticated-orcid":false,"given":"V. C. B.","family":"Pontes","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-5401","authenticated-orcid":false,"given":"M. T.","family":"Gamberini","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas da Santa Casa de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,9]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1080\/10412905.2006.9699207","article-title":"Volatile oil constituents of Campomanesia phaea (O. Berg) Landrum. (Myrtaceae)","volume":"18","author":"ADATI R.T.","year":"2006","journal-title":"The Journal of Essential Oil Research"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.phymed.2018.10.023","article-title":"Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats","volume":"15","author":"AEKTHAMMARAT D.","year":"2019","journal-title":"Phytomedicine"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3181\/00379727-94-22948","article-title":"A new simple method for indirect determination of blood pressure in the rat","volume":"94","author":"ALEXANDER C.S.","year":"1957","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/jsfa.7756","article-title":"Physicochemical variability of cambuci fruit (Campomanesia phaea) from the same orchard, from different locations and at different ripening stages","volume":"97","author":"AZEVEDO M.C.S.","year":"2017","journal-title":"Journal of the Science of Food and Agriculture"},{"key":"ref5","series-title":"Cambuci - 10 Benef\u00edcios para tua sa\u00fade!","author":"BRANCO B.","year":"2018"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1037\/0735-7044.109.5.955","article-title":"Time structure of self-grooming in the rat: self-facilitation and effects of hypothalamic stimulation and neuropeptides","volume":"109","author":"BRESSERS W.M.","year":"1995","journal-title":"Behavioral Neuroscience"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.foodres.2014.12.032","article-title":"Phenolic compounds from cambuci (Campomanesia phaea O. Berg) fruit attenuate glucose intolerance and adipose tissue inflammation induced by a high-fat, high-sucrose diet","volume":"69","author":"DONADO-PESTANA C.M.","year":"2015","journal-title":"Food Research International"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neulet.2012.09.052","article-title":"Modulatory role of M2 muscarinic receptor on apomorphine-induced yawning and genital grooming","volume":"531","author":"GAMBERINI M.T.","year":"2012","journal-title":"Neuroscience Letters"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neulet.2014.10.027","article-title":"Involvement of dopaminergic and cholinergic pathways in the induction of yawning and genital grooming by the aqueous extract of Saccharum officinarum L. (sugarcane) in rats","volume":"584","author":"GAMBERINI M.T.","year":"2015","journal-title":"Neuroscience Letters"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2015.03.053","article-title":"Effects of the aqueous extract of Pimpinella anisum L. seeds on exploratory activity and emotional behavior in rats using the open field and elevated plus maze tests","volume":"168","author":"GAMBERINI M.T.","year":"2015","journal-title":"Journal of Ethnopharmacology"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0163-7258(81)90081-4","article-title":"ACTH-induced excessive grooming in the rat","volume":"12","author":"GISPEN W.","year":"1981","journal-title":"Pharmacology & Therapeutics"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4330\/wjc.v7.i4.204","article-title":"Autonomic and endocrine control of cardiovascular function","volume":"7","author":"GORDAN R.","year":"2015","journal-title":"World Journal of Cardiology"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1046\/j.1460-9568.2002.01976.x","article-title":"Enhanced motivation to self-administer cocaine is predicted by self-grooming behaviour and relates to dopamine release in the rat medial prefrontal cortex and amygdala","volume":"15","author":"HOMBERG J.R.","year":"2002","journal-title":"The European Journal of Neuroscience"},{"key":"ref14","series-title":"Campomanesia PHAEA (Cambuci) fruta Ex\u00f3tica e rara","year":"2018"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0361-9230(83)90162-4","article-title":"The time course of excessive grooming after neuropeptide administration","volume":"11","author":"ISAACSON R.","year":"1983","journal-title":"Brain Research Bulletin"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/0018-506X(79)90027-8","article-title":"ACTH-Induced excessive grooming in the rat: The Influence of Enviromental and Motivation Factors","volume":"12","author":"JOLLES J.","year":"1979","journal-title":"Hormones and Behavior"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"KALUEFF A.V.","year":"2016","journal-title":"Nature Reviews. Neuroscience"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.30958\/ajs.4-1-3","article-title":"The potencial of Campomanesia phaea O. Berg Landrum (Cambuci) as natural source of vitamin C","volume":"24","author":"LE\u00c3O M.M.","year":"2017","journal-title":"Athens Journal of Sciences"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1590\/S0100-204X2005000700012","article-title":"Secagem e armazenamento de sementes de cambuci","volume":"40","author":"MALUF A.M.","year":"2005","journal-title":"Pesquisa Agropecu\u00e1ria Brasileira"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132884","article-title":"Glucagon increases beating rate but not contractility in rat right atrium. Comparison with isoproterenol","volume":"10","author":"MERINO B.","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1476-5381.1992.tb09041.x","article-title":"Positive inotropic and negative chronotropic effects of (-)-cis-diltiazem in rat isolated atria","volume":"105","author":"NASA Y.","year":"1992","journal-title":"British Journal of Pharmacology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.yjmcc.2013.01.009","article-title":"Abundance, distribution, mobility and oligomeric state of M2 muscarinic acetylcholine receptors in live cardiac muscle","volume":"57","author":"NENASHEVA T.A.","year":"2013","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137185","article-title":"Unilateral Lesion of Dopamine Neurons Induces Grooming Asymmetry in the Mouse","volume":"10","author":"PELOSI A.","year":"2015","journal-title":"PLoS One"},{"issue":"1-3","key":"ref24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"PRUT L.","year":"2003","journal-title":"European Journal of Pharmacology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2018.08.015","article-title":"Investigation of social, affective and locomotor behavior of adolescent Brattleboro rats reveals a link between vasopressin\u2019s actions on arousal and social behavior","volume":"106","author":"SCHATZ K.C.","year":"2018","journal-title":"Hormones and Behavior"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2010.01.052","article-title":"Dopamine receptor modulation of repetitive grooming actions in the rat: potential relevance for Tourette syndrome","volume":"1322","author":"TAYLOR J.L.","year":"2010","journal-title":"Brain Research"},{"key":"ref27","series-title":"A working list of all species plants","year":"2018"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphys.2018.01073","article-title":"The Newly Synthesized Pyrazole Derivative 5-(1-(3 Fluorophenyl)-1HPyrazol-4-yl)-2H-Tetrazole Reduces Blood Pressure of Spontaneously Hypertensive Rats via NO\/cGMO Pathway","volume":"9","author":"TRINDADE N.R.","year":"2018","journal-title":"Frontiers in Physiology"},{"key":"ref29","first-page":"241","article-title":"Physical and chemical characteristics of cambucizeiro\u2019s fruits (Campomanesia phaea).","volume":"27","author":"VALLILO M.I.","year":"2005","journal-title":"Revista Brasileira de Fruticultura"}],"container-title":["Brazilian Journal of Biology"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjb\/v80n3\/1519-6984-bjb-1519-6984217046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T23:06:41Z","timestamp":1611443201000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842020000300601&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":29,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["S1519-69842020000300601"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.217046","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]}}}