{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:51:34Z","timestamp":1769007094591,"version":"3.49.0"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract In Brazil, American visceral leishmaniasis (AVL) has become a public health concern due to its high incidence and lethality. This study aimed to analyze the clinical, epidemiological, and laboratory aspects of AVL in a state of Brazil. This descriptive, cross-sectional, retrospective, and quantitative study of notified cases of AVL was carried out in Alagoas between 2008 and 2017 from data obtained from DATASUS\/SINAN. Sociodemographic, clinical, and laboratory variables were analyzed. A descriptive analysis was performed using absolute values and valid percentages, using tables and\/or graphs. Data processing was performed using Stata 12.0\u00ae. Results with P &lt;0.05 were considered statistically significant. During the study period, 352 cases of AVL were reported, of which 6.82% died and 38.92% had met a cure criterion. Male patients were predominant (66.76%). Of the total infected patients, 16.76% had attended only the 1st to the 4th grades, with those most affected aged 1 to 4 years (28.69%). Laboratory diagnostic criteria were most commonly used to confirm the notified cases (76.42%), whereas 51.70% and 8.52% of the cases had positive parasitological and immunofluorescence diagnoses, respectively. Finally, the study showed a higher prevalence of the disease in children, men and in rural residents. Although with low lethality, the expressive frequency of AVL in the State of Alagoas was still verified, since there was an increase in the number of cases during the years of the study.<\/jats:p>","DOI":"10.1590\/1519-6984.238383","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T14:18:43Z","timestamp":1622816323000},"source":"Crossref","is-referenced-by-count":4,"title":["American visceral leishmaniasis in a state of northeastern Brazil: clinical, epidemiological and laboratory aspects"],"prefix":"10.1590","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5918-6247","authenticated-orcid":false,"given":"J. R. S.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Universidade Estadual de Ci\u00eancias da Sa\u00fade de Alagoas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-3469","authenticated-orcid":false,"given":"K. M.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ci\u00eancias da Sa\u00fade de Alagoas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-2712","authenticated-orcid":false,"given":"M. S. G.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ci\u00eancias da Sa\u00fade de Alagoas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-793X","authenticated-orcid":false,"given":"D. C. S.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Cesmac, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0131-0097","authenticated-orcid":false,"given":"M. G. S.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7359-3738","authenticated-orcid":false,"given":"G. C.","family":"Ferreira-J\u00fanior","sequence":"additional","affiliation":[{"name":"Instituto Federal de Educa\u00e7\u00e3o, Ci\u00eancia e Tecnologia do Acre, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-3008","authenticated-orcid":false,"given":"L. C.","family":"Alves","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-6780","authenticated-orcid":false,"given":"F. A.","family":"Brayner","sequence":"additional","affiliation":[{"name":"Instituto Aggeu Magalh\u00e3es, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5153-6583","authenticated-orcid":false,"given":"T. J.","family":"Matos-Rocha","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Ci\u00eancias da Sa\u00fade de Alagoas, Brasil; Centro Universit\u00e1rio Cesmac, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"1","key":"ref1","first-page":"191","article-title":"Leishmaniose visceral no Brasil: artigo de revis\u00e3o","volume":"19","author":"AGUIAR P.F.","year":"2017","journal-title":"Revista Unimontes Cient\u00edfica"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1590\/S0037-86822010000200017","article-title":"Leishmaniose visceral: estudo retrospectivo de fatores associados \u00e0 letalidade","volume":"43","author":"ALVARENGA D.G.","year":"2010","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.12662\/2317-3076jhbs.v6i2.1764.p133-139.2018","article-title":"Leishmaniose visceral humana: estudo do perfil cl\u00ednico-epidemiol\u00f3gico na regi\u00e3o leste de Minas Gerais, entre 2008-2015","volume":"6","author":"ALVES W.A.","year":"2018","journal-title":"Journal of Health & Biological Sciences"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1590\/0102-311X00158614","article-title":"Study of implementation and direct cost estimates for diagnostic tests for human visceral leishmaniasis in an urban area in Brazil","volume":"31","author":"ASSIS T.S.","year":"2015","journal-title":"Cadernos de Saude Publica"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.21680\/2446-7286.2016v2n1ID8559","article-title":"Leishmaniose visceral humana no munic\u00edpio de Natal-RN: an\u00e1lise cl\u00ednico-epidemiol\u00f3gica e espacial","volume":"2","author":"BARBOSA I.R.","year":"2016","journal-title":"Revista Ci\u00eancia Plural"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"672","DOI":"10.22278\/2318-2660.2013.v37.n3.a439","article-title":"Aspectos da Coinfec\u00e7\u00e3o Leishmaniose visceral e HIV no Nordeste do Brasil","volume":"37","author":"BARBOSA I. 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