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Biol."],"abstract":"<jats:p>Abstract Desvenlafaxine succinate (DVS) inhibits serotonin reuptake selectively and is approved for major depressive disorders. This research investigated influence of DVS on modulating brain monoamine and oxidative stress in mice. The antiepileptic potential of DVS (10, 20, or 30 mg\/kg\/i.p.) in pentylenetetrazole (PTZ; 85 mg\/kg) with i.p. route of administration, strychnine (STR; 75 mg\/kg) with i.p. route, pilocarpine (400 mg\/kg) with s.c. route and maximal electroshock MES-induced convulsion in mouse models. The activities of oxidative stress, i.e. superoxide dismutase (SOD), glutathione (GSH) and lipid peroxidation (LPO) as well as gamma-aminobutyric acid (GABA) in the brains of PTZ-induced convulsive mice. Treatment with DVS increased the latency to develop siezures and declined mortalities in rodents against PTZ, STR and pilocarpine-induced convulsions. Results of MES-leaded siezures revealed that DVS reduced tonic hind limb extension duration and mortalities significantly. Brain, SOD, GSH and GABA level were significantly (P&lt;0.01) increased and LPO reduced significantly (P&lt;0.01) after DVS treatment. Furthermore, the DVS did not show any motor coordination signs in the rotarod test. We demonstrated that the role of DVS in convulsion genesis in mice under control condition and attenuate the PTZ-induced oxidative damage.<\/jats:p>","DOI":"10.1590\/1519-6984.246194","type":"journal-article","created":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T12:27:41Z","timestamp":1630067261000},"source":"Crossref","is-referenced-by-count":2,"title":["Anticonvulsant effects of desvenlafaxine on modulating brain monoamine and oxidative stress in mice"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-1890","authenticated-orcid":false,"given":"Khalid Saad","family":"Alharbi","sequence":"first","affiliation":[{"name":"Jouf University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.13005\/bpj\/1610","article-title":"Neuroprotective effects of low dose anandamide in pentylenetetrazole-induced kindling in rats","volume":"12","author":"ABDEL-SALAM O.M.","year":"2019","journal-title":"Biomedical & Pharmacology Journal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cbi.2016.05.015","article-title":"Sodium arsenite-induced myocardial bruise in rats: ameliorative effect of naringin via TGF-\u03b2\/Smad and Nrf\/HO pathways","volume":"253","author":"ADIL M.","year":"2016","journal-title":"Chemico-Biological Interactions"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0098530","article-title":"Desvenlafaxine may accelerate neuronal maturation in the dentate gyri of adult male rats","volume":"9","author":"ASOKAN A.","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1590\/1519-6984.228825","article-title":"Chemical composition of Zhumeria majdae essential oil and its effects on the expression of morphine withdrawal syndrome and tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice","volume":"81","author":"AZIMI G.","year":"2021","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"1615","key":"ref5","article-title":"Serotonin and beyond: therapeutics for major depression","volume":"368","author":"BLIER P.","year":"2013","journal-title":"Philosophical Transactions of the Royal Society of London. 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