{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:05:19Z","timestamp":1753887919126,"version":"3.41.2"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Serum toxic metals have been implicated in development of many diseases. This study investigated the association between blood levels of lead and cadmium with abnormal bone mineral density (BMD) and incidence of osteoporosis. Sixty Saudi male adults age matching were assigned into two groups: A healthy control group (n = 30) and osteoporosis patients diagnosed according to T-score (n = 30). Serum calcium, vitamin D, osteocalcin, lead, cadmium were measured. Osteoporotic group showed a highly significant elevation of blood lead and cadmium levels compared to the control group (p &lt;0.001). BMD was negatively correlated with serum osteocalcin level compared with control. There was a significant negative correlation between the cadmium and lead levels (r=-0.465 and p-value = 0.01) and calcium (p &lt; 0.004). Our findings suggested that high cadmium and lead were negative correlated to BMD and increased the risk factor for osteoporosis.<\/jats:p>","DOI":"10.1590\/1519-6984.248828","type":"journal-article","created":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T12:05:10Z","timestamp":1631707510000},"source":"Crossref","is-referenced-by-count":7,"title":["Association of blood heavy metal levels with osteocalcin abnormality and incidence of osteoporosis in Saudi subjects"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8303-9351","authenticated-orcid":false,"given":"A. A.","family":"Banjabi","sequence":"first","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-7456","authenticated-orcid":false,"given":"K.","family":"Kannan","sequence":"additional","affiliation":[{"name":"University School of Medicine,  USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-1067","authenticated-orcid":false,"given":"T. A.","family":"Kumosani","sequence":"additional","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia; King Abdulaziz University,  Saudi Arabia; King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3114-8468","authenticated-orcid":false,"given":"J. M.","family":"Yousef","sequence":"additional","affiliation":[{"name":"University of Jeddah,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-8567","authenticated-orcid":false,"given":"K. O.","family":"Abulnaja","sequence":"additional","affiliation":[{"name":"King Abdulaziz University,  Saudi Arabia; King Abdulaziz University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2384-3700","authenticated-orcid":false,"given":"S. S.","family":"Moselhy","sequence":"additional","affiliation":[{"name":"Ain Shams University,  Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1289\/ehp.8763","article-title":"Cadmium-induced effects on bone in a population-based study of women","volume":"114","author":"AKESSON A.","year":"2006","journal-title":"Environmental Health Perspectives"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/604535","article-title":"Amelioration of cadmium-produced teratogenicity and genotoxicity in mice given Arthrospira maxima (Spirulina) treatment","volume":"2013","author":"ARG\u00dcELLES-VEL\u00c1ZQUEZ N.","year":"2013","journal-title":"Evidence-Based Complementary and Alternative 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