{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T23:15:12Z","timestamp":1778973312817,"version":"3.51.4"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Plant-derived products can assist in the healing process of dermal wounds. It has been demonstrated that Hancornia speciosa latex present angiogenic, osteogenic, anti-inflammatory, and antioxidant activities. Then, it could contribute to the wound healing process. However, natural products in contact with skin may cause dermatitis. The objective of this work was to evaluate the allergic and irritant potential of H. speciosa serum fraction latex using in vitro assays. The obtained results showed that the H. speciosa serum fraction latex has a slightly irritant potential and is not cytotoxic neither allergenic for human cells. Moreover, we identified a remarkable low amount of proteins in this material in comparison to Hevea brasiliensis latex. This result could explain the non-allergenic potential of H. speciosa serum fraction latex because proteins present in latex are the main responsible for allergy. This biomaterial could be used as a non-allergenic source for development of new medicines.<\/jats:p>","DOI":"10.1590\/1519-6984.251075","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T19:51:32Z","timestamp":1633981892000},"source":"Crossref","is-referenced-by-count":3,"title":["Hancornia speciosa serum latex fraction: a non-allergenic biomaterial"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-6083","authenticated-orcid":false,"given":"A. F.","family":"Costa","sequence":"first","affiliation":[{"name":"Universidade Estadual de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4840-5130","authenticated-orcid":false,"given":"K. C.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6737-7548","authenticated-orcid":false,"given":"E. F. L. C.","family":"Bail\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-8280","authenticated-orcid":false,"given":"S. S.","family":"Caramori","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0379-1325","authenticated-orcid":false,"given":"M. C.","family":"Valadares","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-1073","authenticated-orcid":false,"given":"P. J.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-1480","authenticated-orcid":false,"given":"L. M.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s10856-014-5255-8","article-title":"Hancornia speciosa latex for biomedical applications: physical and chemical properties, biocompatibility assessment and angiogenic activity","volume":"25","author":"ALMEIDA L.M.","year":"2014","journal-title":"Journal of Materials Science. Materials in Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.saa.2018.11.050","article-title":"Toxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane","volume":"210","author":"ALMEIDA L.M.","year":"2019","journal-title":"Spectrochimica acta. Part A, Molecular and Biomolecular Spectroscopy"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1590\/S0102-86502012000800009","article-title":"Anatomical and functional evaluation of tympanoplasty using a transitory natural latex biomembrane implant from the rubber tree Hevea brasiliensis.","volume":"27","author":"ARA\u00daJO M.M.","year":"2012","journal-title":"Acta Cirurgica Brasileira"},{"issue":"3","key":"ref4","first-page":"939","article-title":"Mangabeira latex production evaluation in Cerrado region of Goi\u00e1s","volume":"26","author":"ARRUDA A.S.","year":"2016","journal-title":"Ci\u00eancia Florestal"},{"key":"ref5","series-title":"Regedem\u00ae e Biocure. Pele Nova Tecnologia S.A","year":"2021"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202020191584","article-title":"Tissue reaction and anti-biofilm action of new biomaterial composed of latex from Hancornia speciosa Gomes and silver nanoparticles","volume":"92","author":"BONETE J.M.","year":"2020","journal-title":"Anais da Academia Brasileira de Ci\u00eancias"},{"issue":"1-2","key":"ref7","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"BRADFORD M.M.","year":"1976","journal-title":"Analytical Biochemistry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jprot.2018.09.009","article-title":"Correlation between chronic venous ulcer exudate proteins and clinical prole: A cross sectional study","volume":"192","author":"CAVASSAN N.R.V.","year":"2019","journal-title":"Journal of Proteomics"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2478\/v10102-009-0007-1","article-title":"REACH \u2013 an overview","volume":"2","author":"CIH\u00c1K R.","year":"2009","journal-title":"Interdisciplinary Toxicology"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1590\/0001-3765202020190107","article-title":"Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes","volume":"92","author":"D\u2019ABADIA P.L.","year":"2020","journal-title":"Anais da Academia Brasileira de Ci\u00eancias"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2016.04.007","article-title":"Toxicity evaluation of the photoprotective compound LQFM048: eye irritation, skin toxicity and genotoxic endpoints","volume":"376","author":"de \u00c1VILA R.I.","year":"2017","journal-title":"Toxicology"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s10856-013-5089-9","article-title":"Biocompatibility studies of natural rubber latex from different tree clones and collection methods","volume":"25","author":"FLORIANO J.F.","year":"2014","journal-title":"Journal of Materials Science. Materials in Medicine"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1088\/2057-1976\/2\/4\/045007","article-title":"Comparative study of bone tissue accelerated regeneration by latex membranes from Hevea brasiliensis and Hancornia speciosa.","volume":"2","author":"FLORIANO J.F.","year":"2016","journal-title":"Biomedical Physics & Engineering Express"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/j.jaip.2017.05.029","article-title":"Latex allergy: where are we now and how did we get there?","volume":"5","author":"KELLY K.J.","year":"2017","journal-title":"The Journal of Allergy and Clinical Immunology. In Practice"},{"key":"ref15","series-title":"Contact dermatitis","author":"LITCHMAN G.","year":"2017"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0278-6915(85)90030-4","article-title":"Hen\u2019s eggs chorioallantoic membrane test for irritation potential","volume":"23","author":"LUEPKE N.P.","year":"1985","journal-title":"Food and Chemical Toxicology"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jep.2011.03.059","article-title":"The latex obtained from Hancornia speciosa Gomes possesses anti-inflammatory activity","volume":"135","author":"MARINHO D.G.","year":"2011","journal-title":"Journal of Ethnopharmacology"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1007\/s10856-014-5241-1","article-title":"Comparison of the performance of natural latex membranes prepared with different procedures and PTFE membrane in guided bone regeneration (GBR) in rabbits","volume":"25","author":"MOURA J.M.","year":"2014","journal-title":"Journal of Materials Science. Materials in Medicine"},{"key":"ref19","series-title":"Organization for Economic Cooperation and Development. Test Guideline 442E: in Vitro Skin Sensitization, human Cell Line Activation Test (h-CLAT)","year":"2015"},{"key":"ref20","series-title":"Guideline for the testing of chemicals draft proposal for a new test guideline in vitro skin sensitisation: U937 cell line activation test (U-SENS\u2122)","year":"2016"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/pubmed\/fdx119","article-title":"The cost-effectiveness of public health interventions examined by NICE from 2011 to 2016","volume":"40","author":"OWEN L.","year":"2018","journal-title":"Journal of Public Health (Oxford, England)"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.tiv.2015.03.009","article-title":"The myeloid U937 skin sensitization test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization","volume":"29","author":"PIROIRD C.","year":"2015","journal-title":"Toxicology In Vitro"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.bjp.2015.11.006","article-title":"In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts","volume":"26","author":"REIS MANSUR M.C.P.P.","year":"2016","journal-title":"Braz J Pharmacog"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/1519-6984.20114","article-title":"Evaluation of cytotoxicity and genotoxicity of Hancornia speciosa latex in Allium cepa root model","volume":"76","author":"RIBEIRO T.P.","year":"2016","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1590\/s1980-220x2016049603250","article-title":"Quality of life in patients with chronic wounds: magnitude of changes and predictive factors","volume":"51","author":"SANTOS V.L.","year":"2017","journal-title":"Revista da Escola de Enfermagem da USP"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/jat.3281","article-title":"Integrated decision strategies for skin sensitization hazard","volume":"36","author":"STRICKLAND J.","year":"2016","journal-title":"Journal of Applied Toxicology"}],"container-title":["Brazilian Journal of Biology"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/bjb\/v83\/1519-6984-bjb-83-e251075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T19:51:58Z","timestamp":1633981918000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842023000100275&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":26,"alternative-id":["S1519-69842023000100275"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.251075","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e251075"}}