{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:37:55Z","timestamp":1767908275101,"version":"3.49.0"},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract The study was designed to investigate the effect of Coconut Oil on the levels of some liver and hematological parameters in carbon tetrachloride intoxicated rabbits. Also the antioxidant capacity of Coconut Oil for various concentrations was assessed on the basis of percent scavenging of (DPPH) free radical. Experimental animals were divided into five groups, eight rabbits in each group. These were: group A (Normal control), group B (Toxic control), group C (Standard control), group D (Treated with Coconut Oil 50 mL\/kg body weight after CCl4 intoxication), group E (Treated with Coconut Oil 200 mL\/kg body weight after CCl4 intoxication). The effects observed were compared with a standard hepatoprotective drug silymarine (50 mL\/kg body weight). The Coconut Oil (200 mL\/kg body weight) significantly (P&lt;0.05) reduced the elevated serum levels of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) when compared to a toxic control rabbits. The results of extract treated rabbits were similar to silymarine administered rabbits group. Treatment with Coconut Oil root and silymarine caused no significant changes in RBC, Platelets, (Hb), (MCH) concentration and (HCT) values. However, significant (P&lt;0.05) increase was observed in the total WBC count. The present study suggested that Coconut Oil can be used as an herbal alternative (need further exploration i.e to detect its bioactive compound and its efficacy) for hepatoprotective activity.<\/jats:p>","DOI":"10.1590\/1519-6984.252555","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T13:43:47Z","timestamp":1647438227000},"source":"Crossref","is-referenced-by-count":2,"title":["Beneficial effects of coconut oil (Cocos nucifera) on hematobiochemicl and histopathological markers in CCL4-intoxicated rabbits"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7186-5680","authenticated-orcid":false,"given":"B.","family":"Ahmad","sequence":"first","affiliation":[{"name":"University of Malakand,  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9273-3257","authenticated-orcid":false,"given":"W.","family":"Khan","sequence":"additional","affiliation":[{"name":"University of Malakand,  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3860-2424","authenticated-orcid":false,"given":"T. U.","family":"Haq","sequence":"additional","affiliation":[{"name":"University of Malakand,  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Islamia College Peshawar,  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4528-8517","authenticated-orcid":false,"given":"M.","family":"Zahoor","sequence":"additional","affiliation":[{"name":"University of Malakand,  Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0360-1501","authenticated-orcid":false,"given":"A.","family":"Alotaibi","sequence":"additional","affiliation":[{"name":"Princess Nourah bint Abdulrahman University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2860-467X","authenticated-orcid":false,"given":"R.","family":"Ullah","sequence":"additional","affiliation":[{"name":"King Saud University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.14202\/vetworld.2017.461-466","article-title":"Some hematological and biochemical parameters of different goat breeds in Sultanate of Oman \u201ca preliminary study\u201d","volume":"10","author":"AL-BULUSHI S.","year":"2017","journal-title":"Veterinary World"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111391","article-title":"Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats","volume":"138","author":"ASSADI S.","year":"2021","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: a review","volume":"33","author":"ATANASOV A.G.","year":"2015","journal-title":"Biotechnology Advances"},{"key":"ref4","series-title":"Mental health practitioner\u2019s guide to HIV\/AIDS.","first-page":"181","volume-title":"Declaration of Helsinki.","author":"B\u0102D\u0102R\u0102U D.O.","year":"2013"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1007\/s10620-006-9472-y","article-title":"Drug-induced liver injury: review article","volume":"52","author":"BLEIBEL W.","year":"2007","journal-title":"Digestive Diseases and Sciences"},{"key":"ref6","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1731459","article-title":"Antiulcer activity and potential mechanism of action of the leaves of spondias mombin L","volume":"2018","author":"BRITO S.A.","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"ref7","series-title":"Cocos nucifera (coconut)","year":"2017"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34275","article-title":"Optogenetic dissection of descending behavioral control in Drosophila","volume":"7","author":"CANDE J.","year":"2018","journal-title":"eLife"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.jhep.2020.11.001","article-title":"Hepatotoxicity following administration of onasemnogene abeparvovec (AVXS-101) for the treatment of spinal muscular atrophy","volume":"74","author":"CHAND D.","year":"2021","journal-title":"Journal of Hepatology"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1345\/aph.140062","article-title":"Pharmacists\u2019 knowledge and attitudes toward herbal medicine","volume":"41","author":"CHANG Z.G.","year":"2007","journal-title":"The Annals of Pharmacotherapy"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jchromb.2017.08.016","article-title":"The effect of deep eutectic solvent on the pharmacokinetics of salvianolic acid B in rats and its acute toxicity test","volume":"1063","author":"CHEN J.","year":"2017","journal-title":"Journal of Chromatography. 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