{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:35:03Z","timestamp":1787499303160,"version":"build-2736575974"},"reference-count":84,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Plants have profound therapeutic benefits, more economical treatments, fewer side effects, and a relatively cheap cost, making them a source of drugs for protective, preventative, curative, or conducive purposes and creating novel phytomedicines. Plant derived medicines are relatively safe compared to synthetic medicines. Many plants have proved to successfully aid in the treatment of diabetes including Filago hurdwarica (Wall. ex DC.) Wagenitz. The current investigations were therefore designed to assess the phytochemical, antioxidant, antidiabetic, and antihyperlipidemic activities of F. hurdwarica. The phytochemical investigations and antioxidant activities of different extracts were carried out using standard chemical tests, DPPH, and H2O2 scavenging assays. F. hurdwarica plant extract in Hydromethanolic solution were prepared by Soxhletation method and stored in refrigerator at 4\u00b0C for two days before use. Swiss Albino mice were made diabetic by a single dose of alloxan (150 mg\/kg). Hydromethanolic plant extract and fractions of F. hurdwarica were screened for antidiabetic activity and given to the alloxan-induced diabetic mice at a concentration of 150-250 mg\/kg of body weight in different groups of 6 diabetic mice each orally once a day for 15 days. Glibenclamide is also given to another group to as a standard drug to support the result at a dose of 10 mg\/kg of body weight orally once a day for 15 days. Blood glucose levels and body weights of mice were measured on 0, 4, 7, 11 and 15th days. The study found that the extract was safe up to the dose level of 2000 mg\/kg and the dose response effect of chloroform extract (150-250 mg\/kg) of F. hurdwarica showed expressive antihyperglycemic effects and also improved other altered biochemical parameters associated with diabetes. The FTIR and XRD spectra demonstrated the occurrence of phenols, alcohols, alkenes, alkyl halides, ketones, and aromatic compounds and confirmed the amorphous nature of the extract. GC-MS spectral analysis showed the tentative presence of 31 phytochemical constituents in the chloroform extract of F. hurdwarica with different retention time. To conclude, the chloroform extract (250 mg\/kg) of F. hurdwarica revealed considerable antioxidant, antihyperglycemic, and antihyperlipidemic potential and is safe for treating diabetes and related complications.<\/jats:p>","DOI":"10.1590\/1519-6984.261518","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T09:39:26Z","timestamp":1665999566000},"source":"Crossref","is-referenced-by-count":4,"title":["Phytochemical Analysis and hypoglycemic potential of Filago hurdwarica (Wall. ex DC.) Wagenitz in alloxan induced diabetic mice"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-9049","authenticated-orcid":false,"given":"S.","family":"Rahman","sequence":"first","affiliation":[{"name":"Abdul Wali Khan University Mardan,  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4231-9581","authenticated-orcid":false,"given":"Gul","family":"Jan","sequence":"additional","affiliation":[{"name":"Abdul Wali Khan University Mardan,  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-3696","authenticated-orcid":false,"given":"F. Gul","family":"Jan","sequence":"additional","affiliation":[{"name":"Abdul Wali Khan University Mardan,  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8469-8308","authenticated-orcid":false,"given":"H. Ur","family":"Rahim","sequence":"additional","affiliation":[{"name":"The University of Agriculture,  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"5","key":"ref1","first-page":"332","article-title":"Metformin: an effective attenuator of risperidone-induced insulin resistance hyperglycemia and dyslipidemia in rats","volume":"49","author":"ADENEYE A.A.","year":"2011","journal-title":"Indian Journal of Experimental Biology"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.lwt.2010.05.014","article-title":"Encapsulation by spray drying of bioactive components, physicochemical and morphological properties from purple sweet potato","volume":"43","author":"AHMED M.","year":"2010","journal-title":"Lebensmittel-Wissenschaft + Technologie"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.etap.2015.11.022","article-title":"Textile industrial effluent induces mutagenicity and oxidative DNA damage and exploits oxidative stress biomarkers in rats","volume":"41","author":"AKHTAR M.F.","year":"2016","journal-title":"Environmental Toxicology and Pharmacology"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S2221-1691(12)60089-6","article-title":"Antidiabetic and hypolipidemic activities of ethanolic leaf extract and fractions of Melanthera scandens","volume":"2","author":"AKPAN E.J.","year":"2012","journal-title":"Asian Pacific Journal of Tropical Biomedicine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2147\/JEP.S240266","article-title":"Antidiabetic activity of extracts of terminalia brownii fresen. Stem bark in mice","volume":"12","author":"ALEMA N.M.","year":"2020","journal-title":"Journal of Experimental Pharmacology"},{"key":"ref6","article-title":"Analysis of bioactive phytochemical compound of (Cyperus alternifolius L.) By using gas chromatography\u2013mass spectrometry","volume":"571","author":"AL-GARA N.I.","year":"2019","journal-title":"IOP Conference Series. Materials Science and Engineering"},{"key":"ref7","author":"ALI R.","year":"1988"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S2221-6189(13)60126-2","article-title":"A review: anti diabetic medicinal plants used for diabetes mellitus","volume":"2","author":"ARUMUGAM G.","year":"2013","journal-title":"Journal of Acute Disease"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1002\/ptr.3482","article-title":"In vitro antimicrobial and antioxidant activities of anthrone and chromone from the latex of Aloe harlana Reynolds","volume":"25","author":"ASAMENEW G.","year":"2011","journal-title":"Phytotherapy Research"},{"key":"ref10","first-page":"1019","article-title":"Phytochemical screening and antioxidant activities of some selected medicinal plants used for malaria therapy in Southwestern Nigeria","volume":"7","author":"AYOOLA G.","year":"2008","journal-title":"Tropical Journal of Pharmaceutical Research"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1039\/C4RA12784F","article-title":"Green synthesis of zinc oxide nanoparticles using Hibiscus subdariffa leaf extract: effect of temperature on synthesis, anti-bacterial activity and anti-diabetic activity","volume":"5","author":"BALA N.","year":"2015","journal-title":"RSC Advances"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2337\/diabetes.48.1.1","article-title":"Role of oxidative stress in diabetic complications: a new perspective on an old paradigm","volume":"48","author":"BAYNES J.W.","year":"1999","journal-title":"Diabetes"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2174\/157339910791658826","article-title":"Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors","volume":"6","author":"BENALLA W.","year":"2010","journal-title":"Current Diabetes Reviews"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.phymed.2012.09.009","article-title":"Antihyperglycemic activity with DPP-IV inhibition of alkaloids from seed extract of Castanospermum australe: investigation by experimental validation and molecular docking","volume":"20","author":"BHARTI S.K.","year":"2012","journal-title":"Phytomedicine"},{"issue":"spe","key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1590\/S0102-86502003001100009","article-title":"Experimental model of induction of diabetes mellitus in rats","volume":"18","author":"CARVALHO E.N.","year":"2003","journal-title":"Acta Cirurgica Brasileira"},{"key":"ref16","first-page":"1113","article-title":"Antioxidant activities and phenolic contents of extracts from Salvinia molesta and Eichornia crassipes","volume":"4","author":"CHANTIRATIKUL P.","year":"2009","journal-title":"Research Journal of Biological Sciences"},{"issue":"6","key":"ref17","first-page":"1575","article-title":"Antidiabetic and antidyslipidemic effects of Heliotropium strigosum in rat models of Type I and Type II diabetes","volume":"73","author":"CHAUDHRY S.R.","year":"2016","journal-title":"Acta Poloniae Pharmaceutica"},{"issue":"27","key":"ref18","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1021\/jf034740d","article-title":"Superoxide radical scavenging activity of the major polyphenols in fresh plums","volume":"51","author":"CHUN O.K.","year":"2003","journal-title":"Journal of Agricultural and Food Chemistry"},{"issue":"11","key":"ref19","first-page":"55","article-title":"Phytochemical analysis, antidiabetic and toxicity studies of the methanolic leaf extract of Detarium microcarpum guill and perr in wistar albino rats","volume":"9","author":"DAVID J.","year":"2017","journal-title":"Journal of Chemical and Pharmaceutical Research"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/09709274.2007.11905984","article-title":"A study on the nutritional status of diabetics and associated risk factors","volume":"21","author":"DEEPASHREE B.","year":"2007","journal-title":"Journal of Human Ecology (Delhi, India)"},{"issue":"1-3","key":"ref21","doi-asserted-by":"crossref","first-page":"44","DOI":"10.31254\/phyto.2013.21308","article-title":"Antidiabetic herbal drugs and polyherbal formulation used for diabetes: a review","volume":"2","author":"DWIVEDI C.","year":"2013","journal-title":"J Phytopharmacol"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/157339912799424528","article-title":"Natural products as anti-glycation agents: possible therapeutic potential for diabetic complications","volume":"8","author":"ELOSTA A.","year":"2012","journal-title":"Current Diabetes Reviews"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/jama.2014.18574","article-title":"Blood pressure lowering in type 2 diabetes: a systematic review and meta-analysis","volume":"313","author":"EMDIN C.A.","year":"2015","journal-title":"Journal of the American Medical Association"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.14715\/cmb\/2019.65.2.8","article-title":"Antioxidant and alpha amylase inhibitory activities of Fumaria officinalis and its antidiabetic potential against alloxan induced diabetes","volume":"65","author":"FATIMA S.","year":"2019","journal-title":"Cellular and Molecular Biology"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge","volume":"18","author":"FRIEDEWALD W.T.","year":"1972","journal-title":"Clinical Chemistry"},{"key":"ref26","series-title":"Food antioxidants.","first-page":"1","volume-title":"The mechanism of antioxidant action in vitro.","author":"GORDON M.","year":"1990"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2337\/dc07-1268","article-title":"Determinants of whole-body protein metabolism in subjects with and without type 2 diabetes","volume":"31","author":"GOUGEON R.","year":"2008","journal-title":"Diabetes Care"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"6","DOI":"10.2202\/1553-3840.1288","article-title":"Protective role of Pterocarpus marsupium in diabetes-induced hyperlipidemic condition","volume":"6","author":"GUPTA R.","year":"2009","journal-title":"Journal of Complementary & Integrative Medicine"},{"key":"ref29","series-title":"Free radicals in biology and in medicine.","volume-title":"Antioxidant defenses.","author":"HALLIWELL B.","year":"1999"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/187152809787582561","article-title":"A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases","volume":"8","author":"HASANI-RANJBAR S.","year":"2009","journal-title":"Inflammation & Allergy Drug Targets"},{"key":"ref31","first-page":"1","article-title":"GC-MS study on the potentials of Syzygium aromaticum","volume":"2","author":"HEMA R.","year":"2010","journal-title":"Researcher"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0378-8741(89)90001-9","article-title":"A review of natural products and plants as potential antidiabetic drugs","volume":"27","author":"IVORRA M.D.","year":"1989","journal-title":"Journal of Ethnopharmacology"},{"key":"ref33","first-page":"196","article-title":"Antihyperglycemic effect of Diospyros melanoxylon (Roxb.) bark against alloxan-induced diabetic rats","volume":"1","author":"JADHAV J.","year":"2009","journal-title":"International Journal of Pharm Tech Research"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1677\/joe.0.1550283","article-title":"Comparative toxicity of alloxan, N-alkylalloxans and ninhydrin to isolated pancreatic islets in vitro","volume":"155","author":"J\u00d6RNS A.","year":"1997","journal-title":"The Journal of Endocrinology"},{"key":"ref35","first-page":"33","article-title":"In vitro and in vivo antioxidant and antidiabetic efficacy of Cassia auriculata L. flowers","volume":"6","author":"JYOTHI S.","year":"2012","journal-title":"Global Journal of Pharmacology"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/cs0940623","article-title":"Increased oxidative stress in rat liver and pancreas during progression of streptozotocin-induced diabetes","volume":"94","author":"KAKKAR R.","year":"1998","journal-title":"Clinical Science"},{"issue":"2-3","key":"ref37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0378-8741(03)00148-X","article-title":"Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats","volume":"87","author":"KAMALAKKANNAN N.","year":"2003","journal-title":"Journal of Ethnopharmacology"},{"issue":"1-2","key":"ref38","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0891-5849(99)00028-3","article-title":"Increased activity of H2O2 in aorta isolated from chronically streptozotocin-diabetic rats: effects of antioxidant enzymes and enzyme inhibitors","volume":"27","author":"KARASU \u00c7.","year":"1999","journal-title":"Free Radical Biology & Medicine"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jep.2006.03.042","article-title":"Hypoglycemic and antihyperglycemic activity of Aegle marmelos seed extract in normal and diabetic rats","volume":"107","author":"KESARI A.N.","year":"2006","journal-title":"Journal of Ethnopharmacology"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1995-7645(11)60101-6","article-title":"Antidiabetic, hypolipidemic and histopathological analysis of Dillenia indica (L.) leaves extract on alloxan induced diabetic rats","volume":"4","author":"KUMAR S.","year":"2011","journal-title":"Asian Pacific Journal of Tropical Medicine"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/pds.5034","article-title":"Risk of severe hypoglycemic events from amiodarone\u2010sulfonylureas interactions: a population\u2010based nested case\u2010control study","volume":"29","author":"LAI J.H.","year":"2020","journal-title":"Pharmacoepidemiology and Drug Safety"},{"key":"ref42","first-page":"33","article-title":"Hyperuricemia, high serum urea and hypoproteinemia are the risk factor for diabetes","volume":"1","author":"LAL S.S.","year":"2009","journal-title":"Asian Journal of Medical Sciences"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00125-007-0886-7","article-title":"The mechanisms of alloxan-and streptozotocin-induced diabetes","volume":"51","author":"LENZEN S.","year":"2008","journal-title":"Diabetologia"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"466","DOI":"10.3390\/ijms13010466","article-title":"Fungus-mediated green synthesis of silver nanoparticles using Aspergillus terreus","volume":"13","author":"LI G.","year":"2012","journal-title":"International Journal of Molecular Sciences"},{"issue":"8","key":"ref45","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3390\/nu9080801","article-title":"Anti-diabetic effects of phenolic extract from rambutan peels (Nephelium lappaceum) in high-fat diet and streptozotocin-induced diabetic mice","volume":"9","author":"MA Q.","year":"2017","journal-title":"Nutrients"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0944-7113(11)80059-0","article-title":"Antidiabetic plants and their active constituents","volume":"2","author":"MARLES R.J.","year":"1995","journal-title":"Phytomedicine"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.ab.2004.12.001","article-title":"Carbohydrate analysis by a phenol\u2013sulfuric acid method in microplate format","volume":"339","author":"MASUKO T.","year":"2005","journal-title":"Analytical Biochemistry"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4172\/2167-0846.1000261","article-title":"Antinociceptive properties of methanolic bark extracts of Terminalia brownii in wistar rats","volume":"5","author":"MBIRI W.","year":"2016","journal-title":"Journal of Pain & Relief"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jtcme.2016.06.008","article-title":"Attenuation of diabetic nephropathy in streptozotocin-induced diabetic rats by Punica granatum Linn. leaves extract","volume":"7","author":"MESTRY S.N.","year":"2016","journal-title":"Journal of Traditional and Complementary Medicine"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.foodchem.2003.05.007","article-title":"Screening of radical scavenging activity of some medicinal and aromatic plant extracts","volume":"85","author":"MILIAUSKAS G.","year":"2004","journal-title":"Food Chemistry"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1248\/bpb.30.1461","article-title":"Reducing effect of matrix metalloproteinase inhibitors on serum triacylglycerol in streptozotocin-induced diabetic rats and Zucker fa\/fa rats","volume":"30","author":"MORIKAWA T.","year":"2007","journal-title":"Biological & Pharmaceutical Bulletin"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1472-6882-13-37","article-title":"Antidiabetic and antihyperlipidemic activity of Piper longum root aqueous extract in STZ induced diabetic rats","volume":"13","author":"NABI S.A.","year":"2013","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"20","key":"ref53","doi-asserted-by":"crossref","first-page":"629","DOI":"10.5897\/JMPR2014.5722","article-title":"Hypoglycemic activity in diabetic rats of stigmasterol and sitosterol-3-O--D-glucopyranoside isolated from Pseuderanthemum palatiferum (Nees) Radlk. leaf extract","volume":"9","author":"NUALKAEW S.","year":"2015","journal-title":"Journal of Medicinal Plants Research"},{"issue":"5","key":"ref54","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1139\/Y07-026","article-title":"Hyperglycemia and hyperlipidemia are associated with endothelial dysfunction during the development of type 2 diabetes","volume":"85","author":"OKON E.B.","year":"2007","journal-title":"Canadian Journal of Physiology and Pharmacology"},{"issue":"17","key":"ref55","first-page":"3129","article-title":"Comparative antioxidant capacity, membrane stabilization, polyphenol composition and cytotoxicity of the leaf and stem of Cissus multistriata","volume":"7","author":"OMALE J.","year":"2008","journal-title":"African Journal of Biotechnology"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.foodchem.2003.07.013","article-title":"Purification and characterization of membrane-bound peroxidases from Metroxylon sagu","volume":"85","author":"ONSA G.H.","year":"2004","journal-title":"Food Chemistry"},{"key":"ref57","first-page":"161","article-title":"Anti-inflammatory effect of Theobroma cacao, root extract","volume":"5","author":"OYEDAPO O.","year":"2004","journal-title":"Journal of Tropical Medicinal Plants"},{"issue":"12","key":"ref58","first-page":"617","article-title":"Effect of Cassia auriculata flowers on blood sugar levels, serum and tissue lipids in streptozotocin diabetic rats","volume":"43","author":"PARI L.","year":"2002","journal-title":"Singapore Medical Journal"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"331","DOI":"10.5897\/JMPR11.1232","article-title":"Phytochemical analysis and antimicrobial potential of methanolic leaf extract of peppermint (Mentha piperita: lamiaceae)","volume":"6","author":"PRAMILA D.","year":"2012","journal-title":"Journal of Medicinal Plants Research"},{"issue":"3","key":"ref60","first-page":"163","article-title":"Hepato and reno protective action of Calendula officinalis L. flower extract","volume":"47","author":"PREETHI K.C.","year":"2009","journal-title":"Indian Journal of Experimental Biology"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/BF02912926","article-title":"Antidiabetic effect ofT. arjuna bark extract in alloxan induced diabetic rats","volume":"21","author":"RAGAVAN B.","year":"2006","journal-title":"Indian Journal of Clinical Biochemistry"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.biopha.2005.07.002","article-title":"A review on the role of antioxidants in the management of diabetes and its complications","volume":"59","author":"RAHIMI R.","year":"2005","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.micpath.2016.12.019","article-title":"Evaluation of anti-cholinesterase, antibacterial and cytotoxic activities of green synthesized silver nanoparticles using from Millettia pinnata flower extract","volume":"103","author":"RAJAKUMAR G.","year":"2017","journal-title":"Microbial Pathogenesis"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.matlet.2014.10.017","article-title":"Green synthesis of silver nanoparticle using Tephrosia tinctoria and its antidiabetic activity","volume":"138","author":"RAJARAM K.","year":"2015","journal-title":"Materials Letters"},{"issue":"9","key":"ref65","doi-asserted-by":"crossref","first-page":"3999","DOI":"10.1039\/C6FO00343E","article-title":"The effect of a plant extract enriched in stigmasterol and \u03b2-sitosterol on glycaemic status and glucose metabolism in alloxan-induced diabetic rats","volume":"7","author":"RAMU R.","year":"2016","journal-title":"Food & Function"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/ajcp\/28.1.56","article-title":"A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases","volume":"28","author":"REITMAN S.","year":"1957","journal-title":"American Journal of Clinical Pathology"},{"key":"ref67","first-page":"3140","article-title":"Phytochemical profiling of ethanolic leaves extract of Ipomoea sepiaria (Koenig Ex. Roxb)","volume":"5","author":"SENTHIL J.","year":"2016","journal-title":"International Journal of Innovative Research in Science Engineering and Technology"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.lfs.2004.07.024","article-title":"Hypoglycaemic activity of Gentiana olivieri and isolation of the active constituent through bioassay-directed fractionation techniques","volume":"76","author":"SEZIK E.","year":"2005","journal-title":"Life Sciences"},{"issue":"5","key":"ref69","first-page":"358","article-title":"Cell cycle inhibitory activity of Piper longum against A549 cell line and its protective effect against metal-induced toxicity in rats","volume":"51","author":"SHARMA A.K.","year":"2014","journal-title":"Indian Journal of Biochemistry & Biophysics"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jep.2009.10.013","article-title":"Anti-diabetic potential of alkaloid rich fraction from Capparis decidua on diabetic mice","volume":"127","author":"SHARMA B.","year":"2010","journal-title":"Journal of Ethnopharmacology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.fct.2019.01.032","article-title":"Ameliorating efficacy of eugenol against metanil yellow induced toxicity in albino Wistar rats","volume":"126","author":"SHARMA U.K.","year":"2019","journal-title":"Food and Chemical Toxicology"},{"issue":"4","key":"ref72","first-page":"323","article-title":"Antihyperglycemic activity of petroleum ether leaf extract of Ficus krishnae L. on alloxan-induced diabetic rats","volume":"76","author":"SIDHU M.C.","year":"2014","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"ref73","first-page":"677","article-title":"Traditional medicinal plants of Manipur as anti-diabetics","volume":"5","author":"SINGH L.W.","year":"2011","journal-title":"Journal of Medicinal Plants Research"},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/toxins12020087","article-title":"Acute oral toxicity of pinnatoxin G in mice","volume":"12","author":"SOSA S.","year":"2020","journal-title":"Toxins"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s12906-017-1757-5","article-title":"Antidiabetic activity and phytochemical screening of extracts of the leaves of Ajuga remota Benth on alloxan-induced diabetic mice","volume":"17","author":"TAFESSE T.B.","year":"2017","journal-title":"BMC Complementary and Alternative Medicine"},{"key":"ref76","first-page":"296","article-title":"Radical scavenging activity and preliminary phytochemical screening of the leaf extracts of T. brownii Fresen","volume":"4","author":"TAREKEGNE W.","year":"2016","journal-title":"World J Pharm Sci"},{"issue":"11","key":"ref77","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.2337\/diabetes.47.11.1722","article-title":"Sulfonylureas enhance exocytosis from pancreatic beta-cells by a mechanism that does not involve direct activation of protein kinase C","volume":"47","author":"TIAN Y.A.","year":"1998","journal-title":"Diabetes"},{"issue":"6","key":"ref78","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s10876-019-01732-3","article-title":"Antidiabetic and antioxidant activity of green synthesized starch nanoparticles: an in vitro study","volume":"31","author":"VARADHARAJ V.","year":"2019","journal-title":"Journal of Cluster Science"},{"key":"ref79","article-title":"Study of the hypoglycemic activity of derivatives of isoflavones from Cicer arietinum L","volume":"2017","author":"WEI Y.","year":"2017","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"3-4","key":"ref80","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.fshw.2014.11.003","article-title":"\u03b1-Glucosidase inhibitors isolated from medicinal plants","volume":"3","author":"YIN Z.","year":"2014","journal-title":"Food Science and Human Wellness"},{"issue":"6","key":"ref81","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3923\/ijp.2015.532.541","article-title":"Antihyperglycemic and antihyperlipidemic effects of Ferula duranii in experimental type 2 diabetic rats","volume":"11","author":"YUSUFOGLU H.","year":"2015","journal-title":"International Journal of Pharmacology"},{"issue":"4","key":"ref82","first-page":"682","article-title":"Ethnobotanical survey of highly effective medicinal plants and phytotherapies to treat diabetes mellitus II in South-West Pakistan","volume":"17","author":"ZAIN-UL-ABIDIN S.","year":"2018","journal-title":"Indian Journal of Traditional Knowledge"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"34","DOI":"10.9734\/aprj\/2020\/v6i130121","article-title":"Ethno botanical study of wild medicinal plants of Peerano Valley, District Malakand, Khyber Pakhtoonkhwa, Pakistan","volume":"6","author":"ZEB A.","year":"2020","journal-title":"Asian Plant Research Journal"},{"key":"ref84","first-page":"139","article-title":"Isolation and biological activity of \u03b2-Sitosterol and Stigmasterol from the roots of indigofera heterantha","volume":"5","author":"ZEB M.","year":"2017","journal-title":"Pharmacy & Pharmacology International Journal"}],"container-title":["Brazilian Journal of Biology"],"original-title":["An\u00e1lise fitoqu\u00edmica e potencial hipoglicemiante de Filago hurdwarica (Wall. ex DC.) Wagenitz em camundongos diab\u00e9ticos induzidos por aloxana"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842024000100393&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T09:40:57Z","timestamp":1665999657000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842024000100393&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":84,"alternative-id":["S1519-69842024000100393"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.261518","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e261518"}}