{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:09:47Z","timestamp":1753888187499,"version":"3.41.2"},"reference-count":110,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract The coronavirus disease outbreak of 2019 (COVID-19) poses a serious threat to public health worldwide. Lung injury is the most common complication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. However, other organs, including the liver, can also be affected. Currently, there is limited evidence that liver impairment is associated with severe SARS-CoV-2 infection. Clinicians will need to determine whether liver injury is caused by an underlying liver condition, COVID-19 therapy, the virus directly, or immune-mediated inflammation or represents a complicated disease course in the context of COVID-19. To address the scarcity of data on histopathological changes and immunological effects on the liver with COVID-19 positivity, we analyze and summarize recent findings. We searched PubMed, Medline, Google Scholar, Science Direct, Scopus, and Web of Science databases up to December 1, 2021, identifying published studies with the search terms \u201cHistopathology in COVID-19,\u201d \u201cCOVID-19,\u201d \u201cPathological changes in liver in COVID-19,\u201d \u201cLiver pathology in COVID-19,\u201d \u201cimmunological effects in liver in COVID-19,\u201d and \u201cSARS-CoV-2.\u201d This concise review will aid clinicians and researchers in better understanding the tissue histopathology and immunological consequences of SARS-CoV-2 on the liver, enabling improved care planning and avoiding future dangers.<\/jats:p>","DOI":"10.1590\/1519-6984.262008","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T18:49:02Z","timestamp":1662749342000},"source":"Crossref","is-referenced-by-count":1,"title":["Potential histopathological and immunological effects of SARS-CoV-2 on the liver"],"prefix":"10.1590","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9277-3996","authenticated-orcid":false,"given":"M. M.","family":"Alnamshan","sequence":"first","affiliation":[{"name":"Imam Abdulrahman Bin Faisal University,  Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2353\/ajpath.2006.051296","article-title":"Systemic viral infections and collateral damage in the liver","volume":"168","author":"ADAMS D.H.","year":"2006","journal-title":"American Journal of Pathology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41598-018-37071-y","article-title":"Fibrogenic gene expression in hepatic stellate cells induced by HCV and HIV replication in a three cell co-culture model system","volume":"9","author":"AKIL A.","year":"2019","journal-title":"Scientific Reports"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1080\/17474124.2020.1794812","article-title":"Liver injury in severe covid-19 infection: current insights and challenges","volume":"14","author":"ALI N.","year":"2020","journal-title":"Expert Review of Gastroenterology & Hepatology"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1016\/j.clinre.2020.05.002","article-title":"Is SARS-CoV-2 associated with liver dysfunction in COVID-19 patients?","volume":"44","author":"ALI N.","year":"2020","journal-title":"Clinics and Research in Hepatology and Gastroenterology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1177\/2050640620924157","article-title":"Liver injury in covid-19: the current evidence","volume":"8","author":"ALQAHTANI S.A.","year":"2020","journal-title":"United European Gastroenterology Journal"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1002\/jmv.25948","article-title":"Elevated interleukin-6 and severe covid-19: a meta-analysis","volume":"92","author":"AZIZ M.","year":"2020","journal-title":"Journal of Medical Virology"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S2468-1253(20)30084-4","article-title":"Covid-19 and the liver: little cause for concern","volume":"5","author":"BANGASH M.N.","year":"2020","journal-title":"The Lancet. 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