{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:06:54Z","timestamp":1753888014788,"version":"3.41.2"},"reference-count":72,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Studies have shown that carbon tetrachloride (CCl4) induces hepatic and renal damage arising from oxidative stress. The present study was undertaken to examine the effect of omega-3 fatty acids and\/or soya isoflavones on CCl4 induced toxicity in male albino rat liver and kidney. For this purpose, 42 rats were divided as follows: group 1, rats serves as the control without any treatment; group 2, rats were administered a single dose of CCl4 intraperitoneally (1 mg\/kg b. wt.); group 3, rats were supplemented daily with omega-300 orally (400 mg\/kg b. wt.); group 4, rats were supplemented daily with pro-S orally (50 mg\/kg b. wt.); group 5, rats were supplemented daily with omega-300 orally for four weeks, then after 24 hours treated with a single dose of CCl4 at the same tested doses. group 6, rats were supplemented daily with pro- S orally for four weeks, then after 24 hours treated with a single dose of CCl4 at the same tested doses; group 7, rats were supplemented daily with an oral combination of omega-300 and pro-S orally for four weeks, then after 24 hours treated with a single dose of CCl4 at the same tested doses. Results showed that CCl4 administration induces hepatic damage indicated by a significant increase in the activities of alkaline phosphatase (ALP), aspartate aminotransferase (AST) and Aalanine aminotransferase (ALT) enzymes and glucose level, with a significant increase in malondialdehyde (MDA) and nitric oxide (NO) levels and a significant decrease of reduced glutathione (GSH) level in liver tissue. Also, CCl4 toxicity induce renal damage manifested in a significant increase in serum urea, creatinine, uric acid, and oxidative stress of kidney tissue reflected by increase of MDA, NO and the decrease of GSH levels. The pre-treatment with omega-3 fatty acids and\/or soya isoflavones revealed ameliorative effect against deleterious effects of CCl4 toxicity on hepatic and renal tissues and all tested parameters. Results of the current study revealed also that the pre-treatment with omega-3 fatty acids and\/or soya isoflavones to rats improved liver and kidney function and produced high antioxidant activity.<\/jats:p>","DOI":"10.1590\/1519-6984.266024","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T14:15:13Z","timestamp":1676038513000},"source":"Crossref","is-referenced-by-count":0,"title":["Influence of omega- 3 fatty acids, soya isoflavones and their combination for abrogating carbon tetrachloride hazards in male rats"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8331-4472","authenticated-orcid":false,"given":"E. S.","family":"Abdel-Baky","sequence":"first","affiliation":[{"name":"Ain Shams University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3815-1766","authenticated-orcid":false,"given":"S. A.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Ain Shams University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5591-2395","authenticated-orcid":false,"given":"M. F.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Ain Shams University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1740-9534","authenticated-orcid":false,"given":"O. N.","family":"Abdel-Rahman","sequence":"additional","affiliation":[{"name":"Ain Shams University, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jsps.2018.02.009","article-title":"Evaluation of the hepatoprotective effect of combination between hinokiflavone and Glycyrrhizin against CCl4 induced toxicity in rats","volume":"26","author":"ABDEL-KADER M.S.","year":"2018","journal-title":"Saudi Pharmaceutical Journal"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/ajcn\/72.3.844","article-title":"Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women","volume":"72","author":"ALEKEL D.L.","year":"2000","journal-title":"The American Journal of Clinical 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