{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T17:17:37Z","timestamp":1782407857909,"version":"3.54.5"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Schistosomiasis is a neglected tropical disease caused by parasitic worms of several species of the genus Schistosoma. Transmission occurs by parasitic larvae that stay in freshwater snails of the genus Biomphalaria. Thus, the search for new products that are biodegradable has increased the interest in products of plant origin. The aim of this article is to review the isolated substances from natural products that showed molluscicidal activity against the species Biomphalaria glabrata in order to reevaluate the most promising prototypes and update the progress of research to obtain a new molluscicide. We perform searches using scientific databases, such as Scientific Electronic Library Online (SciELO), Google schoolar, PUBMED, Web of Science and Latin American and Caribbean Literature on Health Sciences (LILACS). From 2000 to 2022, using the keywords \u201cisolated substances\u201d, \u201cmolluscicidal activity\u201d and \u201cBiomphalaria glabrata\u201d. In the present study, it was possible to observe 19 promising molluscicidal molecules with a lethal concentration below 20 \u00b5g\/mL. Of these promising isolates, only 5 isolates had the CL90 calculated and within the value recommended by WHO: Benzoic acid, 2',4',6'-Trihydroxydihydrochalcone, Divaricatic acid, Piplartine and 2-hydroxy-1,4-naphthoquinone (Lapachol). We conclude that beyond a few results in the area, the researches don\u2019t follow the methodological pattern (exposure time and measure units, toxicity test), in this way, as they don\u2019t follow a pattern on the result\u2019s exposure (LC), not following, in sum, the recommended by WHO.<\/jats:p>","DOI":"10.1590\/1519-6984.266526","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T11:22:27Z","timestamp":1685964147000},"source":"Crossref","is-referenced-by-count":4,"title":["Bioactivity of substances isolated from natural products on mollusks Biomphalaria glabrata (Say, 1818) (Planorbidae): a review"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0330-992X","authenticated-orcid":false,"given":"L. S.","family":"Rangel","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-0908","authenticated-orcid":false,"given":"K. N. F.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0714-4608","authenticated-orcid":false,"given":"J. A. A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8218-834X","authenticated-orcid":false,"given":"R. X.","family":"Faria","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brasil; Funda\u00e7\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s13071-022-05500-7","article-title":"Molecular insights into the heat shock proteins of the human parasitic blood fluke Schistosoma mansoni.","volume":"15","author":"AGUORU N.A.","year":"2022","journal-title":"Parasites & Vectors"},{"key":"ref2","article-title":"C Reproductive alterations of Biomphalaria glabrata (Say, 1818) infected with Angiostrongylus cantonensis (Chen, 1935) and exposed to Euphorbia milii var. hislopii latex","volume":"82","author":"ALBERTO-SILVA A.C.","year":"2022","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/vetsci5040094","article-title":"Phytochemical molluscicides and schistosomiasis: what we know and what we still need to learn","volume":"5","author":"AUGUSTO R.C.","year":"2018","journal-title":"Veterinary Sciences"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1055\/s-0029-1240691","article-title":"Schistomiasis suppressing deoxyphorbol esters from Euphorbia cauducifolia L. 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C.","year":"2013","journal-title":"Biochemistry and Biotechnology Reports."},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1590\/S0074-02761986000400017","article-title":"Latex of coroa de cristo (Euphorbia splendens): an effective molluscicide","volume":"81","author":"VASCONCELOS M.C.","year":"1986","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0958-1669(02)00308-7","article-title":"Engineering secondary metabolite production in plants","volume":"13","author":"VERPOORTE R.","year":"2002","journal-title":"Current Opinion in Biotechnology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1590\/S0100-40422006000200025","article-title":"Os produtos naturais e a qu\u00edmica medicinal moderna","volume":"29","author":"VIEGAS JUNIOR C.","year":"2006","journal-title":"Qu\u00edmica Nova"},{"key":"ref33","series-title":"Report of the Scientific working Group on Plant Molluscicide & Guidelines for evaluation of plant molluscicides.","year":"1983"},{"key":"ref34","series-title":"Guidelines for laboratory and field testing of molluscicides for control of schistosomiasis.","year":"2019"},{"key":"ref35","series-title":"Schistosomiasis","year":"2022"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Bioatividade de subst\u00e2ncias isoladas de produtos naturais em moluscos Biomphalaria glabrata (Say, 1818) (Planorbidae): uma revis\u00e3o"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842023000100600&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T11:23:01Z","timestamp":1685964181000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842023000100600&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":35,"alternative-id":["S1519-69842023000100600"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.266526","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e266526"}}