{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:13:26Z","timestamp":1777893206337,"version":"3.51.4"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Detrusor hypocontractility (DH) is a disease without a gold standard treatment in traditional medicine. Therefore, there is a need to develop innovative therapies. The present report presents the case of a patient with DH who was transplanted with 2 x 106 adipose tissue-derived mesenchymal stem cells twice and achieved significant improvements in their quality of life. The results showed that cell therapy reduced the voiding residue from 1,800 mL to 800 mL, the maximum cystometric capacity from 800 to 550 mL, and bladder compliance from 77 to 36.6 mL\/cmH2O. Cell therapy also increased the maximum flow from 3 to 11 mL\/s, the detrusor pressure from 08 to 35 cmH2O, the urine volume from 267 to 524 mL and the bladder contractility index (BCI) value from 23 to 90. The International Continence on Incontinence Questionnaire - Short Form score decreased from 17 to 8. Given the above, it is inferred that the transplantation of adipose tissue-derived mesenchymal stem cells is an innovative and efficient therapeutic strategy for DH treatment and improves the quality of life of patients affected by this disease.<\/jats:p>","DOI":"10.1590\/1519-6984.268540","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T12:04:30Z","timestamp":1682683470000},"source":"Crossref","is-referenced-by-count":2,"title":["Cell therapy with adipose tissue-derived human stem cells in the urinary bladder improves detrusor contractility and reduces voiding residue"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-6510","authenticated-orcid":false,"given":"H. R. S.","family":"Coelho","sequence":"first","affiliation":[{"name":"Universidade Federal do Mato Grosso do Sul,  Brasil; Universidade Federal do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3276-4198","authenticated-orcid":false,"given":"S. C.","family":"Neves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Mato Grosso do Sul,  Brasil; Universidade Federal do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1928-0802","authenticated-orcid":false,"given":"J. N. S.","family":"Menezes","sequence":"additional","affiliation":[{"name":"Clinica Samari,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2525-7019","authenticated-orcid":false,"given":"A. C. M. B.","family":"Antoniolli-Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Mato Grosso do Sul,  Brasil; Universidade Federal do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3514-3346","authenticated-orcid":false,"given":"R. J.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Mato Grosso do Sul,  Brasil; Universidade Federal do Mato Grosso do Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.aju.2016.06.005","article-title":"The challenges in the diagnosis of detrusor underactivity in clinical practice: a mini-review","volume":"14","author":"AHMED A.","year":"2016","journal-title":"Arab Journal of Urology"},{"issue":"6781","key":"ref2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1136\/bmj.302.6781.894","article-title":"Postoperative retention of urine: a prospective urodynamic study","volume":"302","author":"ANDERSON J.B.","year":"1991","journal-title":"BMJ (Clinical Research Ed.)"},{"issue":"3","key":"ref3","first-page":"26613","article-title":"Cell therapy with mesenquimial stem cells of bone marrow improves renal function in pre-clinical module","volume":"09","author":"ASSIS P.V.","year":"2019","journal-title":"International Journal of Developmental Research"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.biotechadv.2018.03.011","article-title":"Stem cells: their source, potency and use in regenerative therapies with focus on adipose-derived stem cells - a review","volume":"36","author":"BACAKOVA L.","year":"2018","journal-title":"Biotechnology Advances"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5152\/tud.2019.37659","article-title":"Underactive bladder: a review of the current treatment concepts","volume":"45","author":"BAYRAK \u00d6.","year":"2019","journal-title":"Turkish Journal of Urology"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.eururo.2007.01.029","article-title":"Stem cells for regeneration of urological structures","volume":"51","author":"BECKER C.","year":"2007","journal-title":"European Urology"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","DOI":"10.33448\/rsd-v11i1.25299","article-title":"Evaluation of the efficacy and safety of transplantation of adipose-derived stem cells in the treatment of refractory fistulizing Crohn\u2019s disease","volume":"11","author":"BERNARDI L.","year":"2022","journal-title":"Research, Social Development"},{"key":"ref8","series-title":"Cytotherapy","first-page":"245","volume-title":"Phase I trial: the use of autologous cultured adipose-derived stroma\/stem cells to treat patients with non-revascularizable critical limb ischemia","volume":"6","author":"BURA A.","year":"2014"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1002\/nau.23897","article-title":"The International Continence Society (ICS) report on the terminology for adult male lower urinary tract and pelvic floor symptoms and dysfunction","volume":"38","author":"D\u2019ANCONA C.","year":"2019","journal-title":"Neurourology and Urodynamics"},{"issue":"6","key":"ref10","first-page":"369","article-title":"Adipose-derived stromal cells (ASC) - basics and therapeutic approaches in otorhinolaryngology","volume":"93","author":"FR\u00d6LICH K.","year":"2014","journal-title":"Laryngo- Rhino- Otologie"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","DOI":"10.1016\/j.eururo.2015.08.014","article-title":"igns and symptoms of detrusor underactivity: an analysis of clinical presentation and urodynamic tests from a large group of patients undergoing pressure flow studies","volume":"69","author":"GAMMIE A.","year":"2016","journal-title":"European Urology"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1177\/1090820X10386364","article-title":"Clinical applications of mesenchymal stem cells in soft tissue augmentation","volume":"30","author":"HANSON S.E.","year":"2010","journal-title":"Aesthetic Surgery Journal"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.trsl.2013.11.009","article-title":"Adipose stem cells: biology and clinical applications for tissue repair and regeneration","volume":"163","author":"KOKAI L.E.","year":"2014","journal-title":"Translational Research; 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