{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:23:05Z","timestamp":1783340585694,"version":"3.54.6"},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Parkia platycephala is the only species of the genus Parkia that is endemic to the brazilian Cerrado and the tree symbol of the state of Tocantins, but there are still few studies regarding its bioprospecting. In this study, we aimed to investigate the phytochemical composition, toxicity and bioactivities of the bark and flower of Parkia platycephala. Hot sequential extractions (Soxhlet) were performed using methanol and hydroethanolic solution (70%), after degreasing the sample (hexane). The presence of flavonoids, tannins, steroids and alkaloids was detected in the preliminary screening. Trilinolein, (Z)-9-octadecenamide, 3-O-methyl-d-glucose were detected by Gas Chromatography coupled to Mass Spectrometry (GC-MS). In the Liquid Chromatography with Diode Array Detector (LC-PDA) analysis, it was detected exclusively ferulic acid (bark) and ellagic acid (flower). The ethanolic extract of the bark (IC50=10.69 \u00b1 0.35 \u00b5gmL-1) has an antioxidant potential (DPPH\u2022 radical) higher than that of the rutin standard (IC50=15.85 \u00b1 0.08 \u00b5gmL-1). All extracts showed excellent anticholinesterase potential (Ellman), with emphasis on the ethanol extract of the flower (IC50 =5.34 \u00b1 0.12 \u00b5gmL-1). Regarding toxicity (Artemia salina), the methanolic extract of the bark and the ethanolic extract of the flower presented high and moderate levels, respectively. Such results limit the concentrations of biological activities in this study, however, the antioxidant and anticholinesterase indices fall short of toxicity. The results demonstrated promising antioxidant and anticholinesterase activities of both the bark and the flower of Parkia platycephala.<\/jats:p>","DOI":"10.1590\/1519-6984.275733","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T11:21:29Z","timestamp":1700479289000},"source":"Crossref","is-referenced-by-count":5,"title":["Parkia from Cerrado: phytochemical bioprospection, toxicity and in vitro bioactivities of bark and flower extracts"],"prefix":"10.1590","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-8961","authenticated-orcid":false,"given":"R. M. N.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Universidade Federal do Tocantins,  Brasil; Universidade Federal do Tocantins,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-0056","authenticated-orcid":false,"given":"C. A. L","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Mato Grosso do Sul,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0746-2211","authenticated-orcid":false,"given":"D. R.","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-3790","authenticated-orcid":false,"given":"S. M.","family":"Morais","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7506-308X","authenticated-orcid":false,"given":"E.","family":"Scapin","sequence":"additional","affiliation":[{"name":"Universidade Federal do Tocantins,  Brasil; Universidade Federal do Tocantins,  Brasil; Universidade Federal do Tocantins,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.31557\/APJCP.2021.22.1.53","article-title":"Cytotoxic and apoptotic activity of aglaforbesin derivative isolated from Aglaia loheri Merr. on HCT116 human colorectal cancer cells","volume":"22","author":"ABALOS N.N.","year":"2021","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.32712\/2446-4775.2022.1285","article-title":"Molecular bioprospecting of plant extracts: experience report of the BIOPROS\/UFV group in the search for antitumor compounds","volume":"16","author":"ALMEIDA A.A.","year":"2022","journal-title":"Revista Fitos"},{"key":"ref3","article-title":"Phenolic compound and fatty acid properties of some microalgae species isolated from Erbil City","volume":"82","author":"ANWER S.S.","year":"2022","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"11","key":"ref4","doi-asserted-by":"crossref","first-page":"8535","DOI":"10.1007\/s11033-020-05896-4","article-title":"Quercetin, chrysin, caffeic acid and ferulic acid ameliorate cyclophosphamide-induced toxicities in SH-SY5Y cells","volume":"47","author":"AYNA A.","year":"2020","journal-title":"Molecular Biology Reports"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.talanta.2017.02.065","article-title":"Evaluation of new natural deep eutectic solvents for the extraction of isoflavones from soy products","volume":"168","author":"BAJKACZ S.","year":"2017","journal-title":"Talanta"},{"key":"ref6","series-title":"Faveira (Parkia platycephala)","first-page":"265","volume-title":"Esp\u00e9cies Arb\u00f3reas Brasileiras","volume":"5","author":"CARVALHO P.E.R.","year":"2014"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"550","DOI":"10.32712\/2446-4775.2021.1123","article-title":"Normativas sanit\u00e1rias e a distribui\u00e7\u00e3o geogr\u00e1fica na fabrica\u00e7\u00e3o de fitoter\u00e1picos no Brasil","volume":"15","author":"CASTRO M.R.","year":"2021","journal-title":"Revista Fitos"},{"issue":"12","key":"ref8","first-page":"1157","article-title":"Protective effects of trilinolein extracted from Panax notoginseng against cardiovascular disease","volume":"23","author":"CHAN P.","year":"2002","journal-title":"Acta Pharmacologica Sinica"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.freeradbiomed.2009.12.011","article-title":"Dietary phenolic acids and ascorbic acid: influence on acid-catalyzed nitrosative chemistry in the presence and absence of lipids","volume":"48","author":"COMBET E.","year":"2010","journal-title":"Free Radical Biology & Medicine"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.crci.2005.02.008","article-title":"Nitrosation and nitration of bioactive molecules: toward the basis of disease and its prevention","volume":"8","author":"D\u2019ISCHIA M.","year":"2005","journal-title":"Comptes Rendus Chimie"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1007\/s11064-020-03105-z","article-title":"Ellagic acid inhibits neuroinfammation and cognitive impairment induced by lipopolysaccharides","volume":"45","author":"DORNELLES G.L.","year":"2020","journal-title":"Neurochemical Research"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.sajb.2020.03.013","article-title":"Antioxidant potential and free radical scavenging activity of Parkia roxburghii, G. 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