{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T03:44:01Z","timestamp":1764906241524,"version":"3.41.2"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract High-intensity physical activity is a non-pharmacological intervention that has been tested as a treatment for Parkinson\u2019s disease (PD). The objective of the study was to investigate the benefits of high-intensity physical exercise on the number of neurons and astrocytes in a a rat model of Parkinson\u2019s disease submitted to training before and after the inducing injury. Seventy Wistar rats were used, distributed as follows: nine rats trained before PD induction (DP-Exa), nine trained after PD induction (DP-Exd), 10 trained before and after PD induction (DP-Exad), and nine sedentary rats (DP-Sed). There were also the same groups but with the rats exposed to the sham surgery (control). High-intensity physical exercise on a vertical ladder was performed before and\/or after PD induction for 5 days\/week, 30-45 min a day, for 4 weeks. PD was induced with an electrolytic lesion (AP -4.9, ML 1.7, and DV 8.1). At the end of the experiment, the brain was removed for Nissl staining and immunohistochemistry of glial fibrillary acidid protein (GFAP) in the substantia nigra and striatum. The DP-Exa, Sham-Exa, DP-Exad, and Sham-Exad groups showed a greater number of neurons and higher expression of GFAP in the substantia nigra and stiatum compared with the the DP-Exd, Sham-Exd, DP-Sed, and Sham-Sed groups. Thus, rats that performed high-intensity training before or before and after PD induction had higher densities of neurons and astrocytes.<\/jats:p>","DOI":"10.1590\/1519-6984.282438","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:28:02Z","timestamp":1728905282000},"source":"Crossref","is-referenced-by-count":1,"title":["The benefits of high-intensity physical exercise before and after Parkinson\u2019s disease induction in rats"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6845-4004","authenticated-orcid":false,"given":"S. V.","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0774-5649","authenticated-orcid":false,"given":"G. M. S.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-2548","authenticated-orcid":false,"given":"P. H. A.","family":"Campos-Junior","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7370-8892","authenticated-orcid":false,"given":"L. C. M.","family":"Dam\u00e1zio","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o del-Rei,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1212\/WNL.0b013e318225ab66","article-title":"Does vigorous exercise have a neuroprotective effect in Parkinson\u2019s disease?","volume":"77","author":"AHLSKOG J.E.","year":"2011","journal-title":"Neurology"},{"issue":"2","key":"ref2","first-page":"122","article-title":"Effects of physical exercise on anxiety-related behaviors in rats","volume":"22","author":"BARBOSA D.F.","year":"2016","journal-title":"British Journal of Sports Medicine"},{"issue":"2","key":"ref3","first-page":"189","article-title":"Aplicacion del teste de la barra transversal modificado para evaluar ratas hemiparkinsonizadas","volume":"15","author":"BLANCO LEZCANO 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carotid artery occlusion","volume":"30","author":"VASCONCELOS N.N.","year":"2021","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/brain\/awu323","article-title":"Physical activity and risk of Parkinson\u2019s disease in the Swedish National March Cohort","volume":"138","author":"YANG F.","year":"2015","journal-title":"Brain"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2007.06.031","article-title":"Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson\u2019s rats","volume":"423","author":"YOON M.C.","year":"2007","journal-title":"Neuroscience Letters"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Os benef\u00edcios do exerc\u00edcio f\u00edsico de alta intensidade antes e ap\u00f3s a indu\u00e7\u00e3o da doen\u00e7a de Parkinson em ratos"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842024000101293&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:28:15Z","timestamp":1728905295000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842024000101293&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":39,"alternative-id":["S1519-69842024000101293"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.282438","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"type":"electronic","value":"1678-4375"},{"type":"print","value":"1519-6984"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e282438"}}