{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:09:09Z","timestamp":1753888149124,"version":"3.41.2"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract For the first time, on the basis of complex research, scientifically based and experimentally proven zootechnical feasibility of using the Prevention-N-A biologics developed by us based on the polysaccharide complex of yeast cells Saccharomyces cerevisiae and the aminoglycoside group bactericidal preparation in the technology of obtaining and growing calves in comparison with the previously approved PS-2 preparation. It is proved that three-time intramuscular injection of PS-2 and Prevention-N-A biologics to down-calvers 45-40, 25-20 and 15-10 days before calving in a dose of 10 ml prevents gynecological diseases and increases reproductive function. Under the influence of preparations in cows, the time of separation of the fetal membranes was reduced by 6.0 and 6.4 hours, retention of placenta, post-parturient complications and breast diseases were prevented. The risk of subinvolution of the uterus and endometritis in the first case decreased by 3.0 and 2.0 times, respectively, and in the second \u2013 was excluded (P&lt;0.05). Against the background of immunocorrection in cows, the time of onset of heat by 11.6 and 14.2 days, the insemination index by 1.6 and 1.8 times, the service period by 22.4 and 28.4 days, and fertilization in 1 oestrus increased by 2.5 and 3.0 times (P&lt;0.05-0.01). It was found that twice intramuscular injection of PS-2 and Prevention-N-A to calves on 2...3rd and 7... 9th day of life in a dose of 3 ml stimulates their growth and development, reduces the incidence. By the end of the growing period, the animals of the 1st and 2nd experimental groups were superior in live weight to control peers by 4.6 and 7.0 kg, rearing - 13.8 and 17.0 kg, and fattening - by 19.4 and 24.2 kg, respectively (P&lt;0.05-0.01). A similar pattern occurred in the nature of changes in exterior measurements and the growth coefficient of animals of the compared groups. In calves of the experimental groups, the incidence of respiratory and digestive organs decreased by 2.3 and 7.0 times, the recovery time - by 1.3 and 4.3 days, respectively, compared to the control (P&lt;0.05).<\/jats:p>","DOI":"10.1590\/1519-6984.283234","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T10:57:51Z","timestamp":1725274671000},"source":"Crossref","is-referenced-by-count":0,"title":["Realization of reproductive qualities of cows and productivity of young stock"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4684-7114","authenticated-orcid":false,"given":"D. A.","family":"Baimukanov","sequence":"first","affiliation":[{"name":"\u00abScientific and Production Centre for Animal Husbandry and Veterinary\u00bb LLP,  the Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0349-5825","authenticated-orcid":false,"given":"V. G.","family":"Semenov","sequence":"additional","affiliation":[{"name":"Chuvash State Agricultural Academy,  Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-6249","authenticated-orcid":false,"given":"A. M.","family":"Ombayev","sequence":"additional","affiliation":[{"name":"NAO \u201cKazakh National Agrarian Research University\u201d,  the Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5457-1720","authenticated-orcid":false,"given":"A. S.","family":"Shamshidin","sequence":"additional","affiliation":[{"name":"Zhangir Khan West Kazakhstan Agrarian - Technical University,  the Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-6442","authenticated-orcid":false,"given":"\u0410. \u0422.","family":"Abylgazinova","sequence":"additional","affiliation":[{"name":"\u201cScientific and Production Centre for Animal Husbandry and Veterinary\u201d LLP,  the Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8795-0700","authenticated-orcid":false,"given":"A. T.","family":"Bissembayev","sequence":"additional","affiliation":[{"name":"\u201cScientific and Production Centre for Animal Husbandry and Veterinary\u201d LLP,  the Republic of Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"380","key":"ref1","doi-asserted-by":"crossref","first-page":"65","DOI":"10.32014\/2019.2518-1467.94","article-title":"Efficient methods in breeding dairy cattle of the Republic of Kazakhstan. 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