{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T01:28:55Z","timestamp":1775093335693,"version":"3.50.1"},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan","award":["BR18574139"],"award-info":[{"award-number":["BR18574139"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract In this study, the biochemical parameters and physico-chemical reactions of the body in experimental hypoxia, using a Sprague Dawley Rat Model. Hypoxia changed the dynamics and biochemical parameters of blood and lymph, as well as urine. During hypoxia, there was a change in the osmotic resistance of erythrocytes. Hypoxic training was conducted in a hypoxic animal chamber for 15 days and 30 days for 40 minutes every day. Physical and chemical parameters of blood, lymph and its morphological composition were studied on a hematological analyser, oxygen tension and pH of blood and lymph on an OPTI CCA-TS2 Blood Gas and Electrolyte Analyser. The value of osmotic pressure in the lymph changed slightly from 280.22 \u00b1 2.07 to 293.3\u00b13.1 and 285.6 \u00b1 2.8 mOsm\/l, respectively, 15 and 30 days of hypoxia. Urine osmotic pressure decreased by 15.1-10.4%, respectively, compared to the control group. After 15 and 30 days of hypoxia, ion exchange in the blood plasma showed a decrease in the concentration of K+, Cl- ions and an increase in the concentration of Na+ ions in the blood plasma and lymph. Ca2+ concentrations decreased in blood plasma and increased in lymph and urine. The analysis of the osmotic resistance of erythrocytes showed its decrease. Lipid peroxidation of erythrocyte membranes showed a significant increase in the level of malondialdehyde and diene conjugates by 52.2% and 69.6%, as well as a decrease in the activity of superoxide dismutase and catalase by 32% and 29.7%. Hypoxia leads to a decrease in erythrocyte resistance and lipid peroxidation in experimental animals. Shifts in pH on the side of acidosis and disturbances in physico-chemical properties in the blood and lymph were detected. As a result of developing hypoxia in the body, structural and functional rearrangements occur in the whole blood of experimental animals.<\/jats:p>","DOI":"10.1590\/1519-6984.284264","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:53:47Z","timestamp":1738925627000},"source":"Crossref","is-referenced-by-count":2,"title":["Lymph flow, ionic and biochemical indicators of lymph and blood during hypoxia"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8527-921X","authenticated-orcid":false,"given":"S. N.","family":"Abdreshov","sequence":"first","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9906-2700","authenticated-orcid":false,"given":"G. A.","family":"Demchenko","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6122-0320","authenticated-orcid":false,"given":"U. N.","family":"Kozhaniyazova","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8665-1458","authenticated-orcid":false,"given":"A. N.","family":"Yeshmukhanbet","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2436-0620","authenticated-orcid":false,"given":"M. A.","family":"Yessenova","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-3496","authenticated-orcid":false,"given":"B. A.","family":"Nurmakhanova","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1248-1520","authenticated-orcid":false,"given":"R. M.","family":"Karjaubaev","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-3580","authenticated-orcid":false,"given":"L. U.","family":"Koibasova","sequence":"additional","affiliation":[{"name":"Institute of Genetics and Physiology CS MSHE RK,  Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1113\/jphysiol.1995.sp020528","article-title":"Effect of hypoxia on force, intracellular pH and Ca2+ concentration in rat cerebral and mesenteric small arteries","volume":"482","author":"AALKJAER C.","year":"1995","journal-title":"The Journal of Physiology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"08003","DOI":"10.1051\/e3sconf\/202015908003","article-title":"The study biochemical indicates of blood rats at conditions acute hypoxia","volume":"159","author":"ABDRESHOV S.","year":"2020","journal-title":"E3S Web of Conferences"},{"issue":"5","key":"ref3","first-page":"509","article-title":"Contractile activity of pectoral channel and lymph nodes in rats under antiorthostatic influences","volume":"97","author":"ABDRESHOV S.N.","year":"2011","journal-title":"Rossiiskii Fiziologicheskii Zhurnal Imeni I. M. Sechenova"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s10517-015-2882-0","article-title":"Lympho- and hemodynamics in dogs with acute experimental pancreatitis","volume":"159","author":"ABDRESHOV S.N.","year":"2015","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s10517-021-05212-5","article-title":"Condition of adrenergic innervation apparatus of the thyroid gland, blood and lymph vessels and lymph nodes during correction of hypothyrosis","volume":"171","author":"ABDRESHOV S.N.","year":"2021","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s10517-010-0723-8","article-title":"Shifts in the lymph flow and the lymph composition in toxic hepatitis and their correction by protective substances","volume":"148","author":"ABDRESHOW S.N.","year":"2009","journal-title":"Bulletin of Experimental Biology and Medicine"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.5551\/jat.RV17009","article-title":"The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases","volume":"24","author":"ABE H.","year":"2017","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"issue":"5","key":"ref8","first-page":"1185","article-title":"A physiological characterization of the high-fat diet on the induction of obesity in adult male Swiss mice","volume":"21","author":"BABASHEV A.","year":"2023","journal-title":"Caspian Journal of Environmental Sciences"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3390\/biomedicines10010059","article-title":"The cardiovascular system in space: focus on in vivo and in vitro studies","volume":"10","author":"BARAN R.","year":"2022","journal-title":"Biomedicines"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-2003-44551","article-title":"Blood rheology and hemodynamics","volume":"29","author":"BASKURT O.K.","year":"2003","journal-title":"Seminars in Thrombosis and Hemostasis"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3390\/cells10051008","article-title":"Transcriptome analysis of hypoxic lymphatic endothelial cells indicates their potential to contribute to extracellular matrix rearrangement","volume":"10","author":"BECKER J.","year":"2021","journal-title":"Cells"},{"issue":"2-3","key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.resp.2007.06.001","article-title":"Hypoxia-related lipid peroxidation: evidences, implications and approaches","volume":"158","author":"BEHN C.","year":"2007","journal-title":"Respiratory Physiology & Neurobiology"},{"key":"ref13","first-page":"100","article-title":"Capillary flow and wall adherence of bovine blood, plasma and serum in contact with glass and fibrin surfaces","volume":"168","author":"COPLEY A.L.","year":"1959","journal-title":"Kolloid- Zeitschrift"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137957","article-title":"Prooxidant\/antioxidant balance in hypoxia: a cross-over study on Normobaric vs. Hypobaric \u201cLive High-Train Low\u201d","volume":"10","author":"DEBEVEC T.","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.2337\/dc12-2113","article-title":"Effects of a single bout of interval hypoxia on cardiorespiratory control and blood glucose in patients with type 2 diabetes","volume":"36","author":"DUENNWALD T.","year":"2013","journal-title":"Diabetes Care"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.bbrc.2016.11.169","article-title":"Hypoxia inhibits lymphatic thoracic duct formation in zebrafish","volume":"482","author":"ERNENS I.","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"ref17","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2021.792863","article-title":"Silencing of activity during hypoxia improves functional outcomes in motor neuron networks in vitro.","volume":"15","author":"FISKUM V.","year":"2021","journal-title":"Frontiers in Integrative Neuroscience"},{"issue":"2","key":"ref18","first-page":"103","article-title":"Hypoxia and extracellular matrix proteins influence angiogenesis and lymphangiogenesis in mouse embryoid bodies","volume":"2","author":"FOSKETT A.M.","year":"2011","journal-title":"Frontiers in Physiology"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3345\/kjp.2019.00850","article-title":"Ferriero Hypoxia-inducible factor: role in cell survival in superoxide dismutase overexpressing mice after neonatal hypoxia-ischemia","volume":"62","author":"GA WON JEON R.","year":"2019","journal-title":"Korean Journal of Pediatrics"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0002-9629(15)40679-2","article-title":"Physiology of renal sodium transport","volume":"319","author":"GREGER R.","year":"2000","journal-title":"The American Journal of the Medical Sciences"},{"key":"ref21","first-page":"383","article-title":"Investigations of viscosity at low rates of shear: effects of variations in the concentration and character of the red cells and in the composition of the suspending medium","volume":"7","author":"GREGERSEN M.I.","year":"1965","journal-title":"Bibliotheca Anatomica"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00421-020-04572-6","article-title":"Effect of normobaric hypoxic exercise on blood pressure in old individuals","volume":"121","author":"HEIN M.","year":"2021","journal-title":"European Journal of Applied Physiology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1515\/jbcpp-2015-0036","article-title":"Phenotypic variations in osmotic lysis of Sahel goat erythrocytes in non-ionic glucose media","volume":"27","author":"IGBOKWE N.A.","year":"2016","journal-title":"Journal of Basic and Clinical Physiology and Pharmacology"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbamcr.2007.03.001","article-title":"Hypoxia alters the adhesive properties of lymphatic endothelial cells. A transcriptional and functional study","volume":"1773","author":"IRIGOYEN M.","year":"2007","journal-title":"Biochimica et Biophysica Acta"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/ps\/77.3.475","article-title":"Fluorometric analysis of 2-thiobarbituric acid reactive substances in turkey","volume":"77","author":"JO C.","year":"1998","journal-title":"Poultry Science"},{"issue":"Pt 1","key":"ref26","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1113\/jphysiol.2007.139360","article-title":"Responses evoked in single sympathetic nerve fibres of the rat tail artery by systemic hypoxia are dependent on core temperature","volume":"584","author":"JOHNSON C.","year":"2007","journal-title":"The Journal of Physiology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3233\/CH-1663301","article-title":"The microcirculation in hypoxia: the center of the battlefield for oxygen","volume":"63","author":"JUNG C.","year":"2016","journal-title":"Clinical Hemorheology and Microcirculation"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3233\/CH-151973","article-title":"Chronic intermittent hypoxia versus continuous hypoxia: same effects on hemorheology?","volume":"63","author":"KANG J.","year":"2016","journal-title":"Clinical Hemorheology and Microcirculation"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"746","DOI":"10.33808\/clinexphealthsci.1018541","article-title":"The effects of therapeutic intermittent hypoxia implementation on complete blood count parameters: an experimental animal model","volume":"12","author":"KILIC T.","year":"2022","journal-title":"Clinical and Experimental Health Sciences"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1172\/JCI40145","article-title":"The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice","volume":"120","author":"LEVIEL F.","year":"2010","journal-title":"The Journal of Clinical Investigation"},{"issue":"13","key":"ref31","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1096\/fasebj.7.13.8405809","article-title":"Ischemia: from acidosis to oxidation","volume":"7","author":"LEVINE R.L.","year":"1993","journal-title":"The FASEB Journal"},{"issue":"2","key":"ref32","first-page":"557","article-title":"Hyperlipidemia and lipid peroxidation depend on the truth of chronic intermittent hypoxia","volume":"102","author":"LI J.","year":"2007","journal-title":"Journal of Applied Physiology (Bethesda, Md.)"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jesf.2021.12.003","article-title":"Methods to match high intensity interval exercise intensity in hypoxia and normoxia \u2013 a pilot study","volume":"20","author":"LI Y.","year":"2022","journal-title":"Journal of Exercise Science and Fitness"},{"issue":"1","key":"ref34","first-page":"1","article-title":"Cellular adaptation to oxygen deficiency beyond the Nobel award","volume":"11","author":"L\u00d3PEZ-BARNEO J.","year":"2020","journal-title":"Nature Communications"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.709509","article-title":"Hypoxia inducible factors as central players in the pathogenesis and pathophysiology of cardiovascular diseases","volume":"8","author":"LUCERO GARC\u00cdA ROJAS E.Y.","year":"2021","journal-title":"Frontiers in Cardiovascular Medicine"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1097\/HJH.0b013e32834b5846","article-title":"Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension","volume":"29","author":"LYAMINA N.P.","year":"2011","journal-title":"Journal of Hypertension"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.freeradbiomed.2018.03.042","article-title":"Hypoxia, oxidative stress and inflammation","volume":"125","author":"MCGARRY T.","year":"2018","journal-title":"Free Radical Biology & Medicine"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fphys.2016.00224","article-title":"Therapeutic use of exercising in hypoxia: promises and limitations","volume":"7","author":"MILLET G.P.","year":"2016","journal-title":"Frontiers in Physiology"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","DOI":"10.1080\/23723556.2015.1024821","article-title":"Role of hypoxia and vascular endothelial growth factors in lymphangiogenesis","volume":"2","author":"MORFOISSE F.","year":"2015","journal-title":"Molecular & Cellular Oncology"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.pcad.2010.03.004","article-title":"Physiological adaptation of the cardiovascular system to high altitude","volume":"52","author":"NAEIJE R.","year":"2010","journal-title":"Progress in Cardiovascular Diseases"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-1-0716-0668-1_25","article-title":"Experimental hypoxia as a model for cardiac regeneration in mice","volume":"2158","author":"NAKADA Y.","year":"2021","journal-title":"Methods in Molecular Biology (Clifton, N.J.)"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.resp.2013.12.011","article-title":"Effect of intermittent hypoxia and exercise on blood rheology and oxygen transport in trained rats","volume":"192","author":"N\u00da\u00d1EZ-ESPINOSA C.","year":"2014","journal-title":"Respiratory Physiology & Neurobiology"},{"issue":"7-8","key":"ref43","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mad.2007.06.007","article-title":"Influence of age on the stability of human erythrocyte membranes","volume":"128","author":"PENHA-SILVA N.","year":"2007","journal-title":"Mechanisms of Ageing and Development"},{"issue":"24","key":"ref44","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.3390\/ijms21249434","article-title":"Accelerated spatial fibrin growth and impaired contraction of blood clots in patients with rheumatoid arthritis","volume":"21","author":"PESHKOVA A.D.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2016.02.001","article-title":"Hypoxia in health and disease","volume":"47-48","author":"POUYSSEGUR J.","year":"2016","journal-title":"Molecular Aspects of Medicine"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1080\/17461391.2017.1388850","article-title":"A the efficacy of resistance training in hypoxia to enhance strength and muscle growth: a systematic review and meta-analysis","volume":"18","author":"RAMOS-CAMPO D.J.","year":"2017","journal-title":"European Journal of Sport Science"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s10517-020-04763-3","article-title":"Acclimatization to middle attitude hypoxia masks the symptoms of experimental posttraumatic stress disorder, but does not affect its pathogenetic mechanisms","volume":"168","author":"RYBNIKOVA E.A.","year":"2020","journal-title":"Bulletin of Experimental Biology and Medicine"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3389\/fphys.2020.00224","article-title":"Effects of hypoxia and acidosis on cardiac electrophysiology and hemodynamics. Is NHE-Inhibition by Cariporide Still Advantageous?","volume":"11","author":"SALAMEH A.","year":"2020","journal-title":"Frontiers in Physiology"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.htct.2019.06.001","article-title":"Stability of refrigerated whole blood samples for osmotic fragility test","volume":"42","author":"SALVAGNO G.L.","year":"2020","journal-title":"Hematology, Transfusion and Cell Therapy"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.673095","article-title":"Physiological effects of intermittent passive exposure to hypobaric hypoxia and cold in rats","volume":"12","author":"SANTOCILDES G.","year":"2021","journal-title":"Frontiers in Physiology"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1146\/annurev-pathol-012513-104720","article-title":"Oxygen sensing, hypoxia-inducible factors, and disease pathophysiology","volume":"9","author":"SEMENZA G.L.","year":"2014","journal-title":"Annual Review of Pathology"},{"issue":"12","key":"ref52","first-page":"460","article-title":"Tissue Acidosis associated with ischemic stroke to guide neuroprotective drug delivery","volume":"9","author":"T\u00d3TH O.M.","year":"2020","journal-title":"Biology (Basel)"},{"issue":"11-12","key":"ref53","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00397-016-0967-y","article-title":"The influence of oxygen concentration on the rheological properties and flow of whole human blood","volume":"55","author":"VALANT A.Z.","year":"2016","journal-title":"Rheologica Acta"},{"issue":"6 Pt 2","key":"ref54","first-page":"1013","article-title":"Effects of diuretic drugs on Na, Cl, and K transport by rat renal distal tubule.","volume":"250","author":"VELAZQUEZ H.","year":"1986","journal-title":"The American Journal of Physiology"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/pcmedi\/pbaa022","article-title":"Long-Term spaceflight and the cardiovascular system","volume":"3","author":"VERNICE N.A.","year":"2020","journal-title":"Precision Clinical Medicine"},{"key":"ref56","article-title":"Individual osmotic fragility distribution: a new parameter for determination of the osmotic properties of human red blood cells","volume":"162102","author":"WALSKI T.","year":"2014","journal-title":"BioMed Research International"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1093\/clinchem\/39.12.2522","article-title":"Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage","volume":"39","author":"WASOWICZ W.","year":"1993","journal-title":"Clinical Chemistry"},{"issue":"7","key":"ref58","first-page":"746","article-title":"The use of an index of hemolysis in expressing the fragility of erythrocytes","author":"WAUGH T.","year":"1938","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"issue":"15","key":"ref59","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.15252\/embj.201696150","article-title":"Endothelial cell metabolism in health and disease: impact of hypoxia","volume":"36","author":"WONG B.W.","year":"2017","journal-title":"The EMBO Journal"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4149\/gpb_2011_04_389","article-title":"The effects of chronic long-term intermittent hypobaric hypoxia on blood rheology parameters","volume":"30","author":"YELMEN N.","year":"2011","journal-title":"General Physiology and Biophysics"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Fluxo linf\u00e1tico, indicadores i\u00f4nicos e bioqu\u00edmicos da linfa e do sangue durante a hip\u00f3xia"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842024000101383&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:54:13Z","timestamp":1738925653000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842024000101383&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":60,"alternative-id":["S1519-69842024000101383"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.284264","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e284264"}}