{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:44:25Z","timestamp":1780368265533,"version":"3.54.1"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Exposure to ultraviolet (UV) radiation is a significant risk factor for sunburn (solar erythema) and skin cancer. Current treatments focus primarily on symptom relief, making the need for new therapeutic approaches urgent. Xanthophylls, a class of natural pigments with antioxidant and anti-inflammatory properties, show promise in the management of UV burns. This review aimed to systematically analyze the potential of xanthophylls for the management of UV burns, evaluating their efficacy in clinical and experimental studies. A literature review was performed following the PRISMA guidelines. Searches were conducted in the PUBMED, Virtual Health Library and EMBASE databases for eligible articles, using combinations of keywords such as astaxanthin, lutein, fucoxanthin and their effects on burns. Three independent reviewers conducted the search and selection of studies with inclusion criteria that addressed the use of xanthophylls in the treatment of burns, their mechanisms of action, pathophysiology and therapeutic approaches. Systematic reviews, letters, conference abstracts and case reports were excluded, considering only articles published in English. The articles were pre-selected by reading titles and abstracts, and the pre-selected studies were read in full for the final selection. Xanthophylls with potential benefits were identified, highlighting lutein, astaxanthin and violaxanthin, which demonstrated antioxidant activity by reducing the generation of reactive oxygen species (ROS) and mitigating inflammatory responses in skin cells exposed to UV radiation. Furthermore, evidence suggests that these xanthophylls promote skin barrier function and accelerate healing, enhancing recovery from UV burns. In conclusion, this review suggests a promising role for xanthophylls in alleviating UV burn symptoms and promoting skin healing. However, further research, including in vivo studies and clinical trials, is needed to validate its therapeutic potential, determine the optimal dosage, and optimize its delivery for effective UV burn control.<\/jats:p>","DOI":"10.1590\/1519-6984.288662","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T11:14:20Z","timestamp":1741950860000},"source":"Crossref","is-referenced-by-count":2,"title":["Xanthophylls: potential benefits in protecting against UV burns"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1633-0787","authenticated-orcid":false,"given":"D. Q.","family":"Tavares","sequence":"first","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-0541","authenticated-orcid":false,"given":"G. C.","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-5010","authenticated-orcid":false,"given":"I. M. A. S.","family":"Mangussi","sequence":"additional","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8072-9648","authenticated-orcid":false,"given":"L. R.","family":"Vital","sequence":"additional","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2182-8782","authenticated-orcid":false,"given":"L. M.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8634-2850","authenticated-orcid":false,"given":"C. R.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Anhembi Morumbi,  Brasil; Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s10753-018-0730-x","article-title":"Burn-induced multiple organ injury and protective effect of lutein in rats","volume":"41","author":"ABUBAKR H.O.","year":"2018","journal-title":"Inflammation"},{"issue":"4","key":"ref2","first-page":"246","article-title":"Perfil epidemiol\u00f3gico de pacientes que sofreram queimaduras no Brasil: revis\u00e3o de literatura","volume":"11","author":"CRUZ B.F.","year":"2012","journal-title":"Revista Brasileira de Queimaduras"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.plipres.2007.07.001","article-title":"Allenic and cumulenic lipids","volume":"46","author":"DEMBITSKY V.M.","year":"2007","journal-title":"Progress in Lipid Research"},{"issue":"16","key":"ref4","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.3390\/molecules25163607","article-title":"Zeaxanthin and lutein: photoprotectors, anti-inflammatories, and brain food","volume":"25","author":"DEMMIG-ADAMS B.","year":"2020","journal-title":"Molecules"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"41440","DOI":"10.1038\/srep41440","article-title":"Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis","volume":"7","author":"FANG Q.","year":"2017","journal-title":"Scientific Reports"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3390\/md13042105","article-title":"Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis","volume":"13","author":"GUO S.X.","year":"2015","journal-title":"Marine Drugs"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1017\/S0007114508199007","article-title":"The distribution and accumulation of fucoxanthin and its metabolites after oral administration in mice","volume":"102","author":"HASHIMOTO T.","year":"2009","journal-title":"British Journal of Nutrition"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"817","DOI":"10.3390\/nu10070817","article-title":"The Protective role of astaxanthin for uv-induced skin deterioration in healthy people: a randomized, double-blind, placebo-controlled Trial","volume":"10","author":"ITO N.","year":"2018","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2021.104243","article-title":"Correlation of skin carotenoid content with 3-day dietary intake in community dwelling older adults","volume":"105","author":"KELLER J.E.","year":"2022","journal-title":"Journal of Food Composition and Analysis"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171178","article-title":"Preventive effect of dietary astaxanthin on UVA-induced skin photoaging in hairless mice","volume":"12","author":"KOMATSU T.","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1046\/j.0022-202X.2004.22227.x","article-title":"Dietary lutein reduces ultraviolet radiation-induced inflammation and immunosuppression","volume":"122","author":"LEE E.H.","year":"2004","journal-title":"The Journal of Investigative Dermatology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jphs.2016.08.004","article-title":"Protective and therapeutic effects of fucoxanthin against sunburn caused by UV irradiation","volume":"132","author":"MATSUI M.","year":"2016","journal-title":"Journal of Pharmacological Sciences"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/antiox8090390","article-title":"Zeaxanthin: metabolism, properties, and antioxidant protection of eyes, heart, liver, and skin","volume":"8","author":"MURILLO A.G.","year":"2019","journal-title":"Antioxidants"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/0148607102026003189","article-title":"A longitudinal evaluation of oxidative stress in trauma patients","volume":"26","author":"OLDHAM K.M.","year":"2002","journal-title":"JPEN. 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