{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T00:34:09Z","timestamp":1758587649712,"version":"3.44.0"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract The aim of this study was to evaluate the probiotic effect of the lactic acid bacterium Lactococcus lactis (L. lactis) in the prevention and treatment of inflammatory bowel disease in mice through a systematic literature review. A literature search was conducted in the Cochrane Library and PubMed databases to evaluate the effect of the lactic acid bacterium L. lactis in the prevention and treatment of inflammatory bowel disease in mice using the descriptors: L. lactis, inflammatory bowel disease, prevention, treatment, Crohn's disease, ulcerative colitis and lactic acid bacteria. A total of 3,320 articles were found, of which only six were included in the review. The results suggest that lactic acid bacteria such as L. lactis may be helpful in the treatment and intestinal modulation of animals exhibiting characteristic signs and symptoms of diseases such as ulcerative colitis and Crohn's disease.<\/jats:p>","DOI":"10.1590\/1519-6984.289047","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T15:02:26Z","timestamp":1758553346000},"source":"Crossref","is-referenced-by-count":0,"title":["Probiotic effect of Lactococcus lactis genetically modified in the prevention and treatment of inflammatory bowel diseases in mice: a systematic review"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8590-2451","authenticated-orcid":false,"given":"T.","family":"Rizzi","sequence":"first","affiliation":[{"name":"Universidade Federal de Pelotas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9222-1238","authenticated-orcid":false,"given":"P. Q.","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-3246","authenticated-orcid":false,"given":"F. M.","family":"Delpino","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0098-1681","authenticated-orcid":false,"given":"T. R.","family":"Flores","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7403-1577","authenticated-orcid":false,"given":"S.","family":"Pieniz","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jsps.2013.07.001","article-title":"Role of probiotics in health improvement, infection control and disease treatment and management","volume":"23","author":"AMARA A.A.","year":"2015","journal-title":"Saudi Pharmaceutical Journal"},{"issue":"3","key":"ref2","first-page":"16","article-title":"Probiotics and their use in inflammatory bowel disease","volume":"24","author":"AMER 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tratamento de doen\u00e7as inflamat\u00f3rias intestinais em camundongos: uma revis\u00e3o sistem\u00e1tica"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100311&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T15:02:32Z","timestamp":1758553352000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100311&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":36,"alternative-id":["S1519-69842025000100311"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.289047","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e289047"}}