{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:23:45Z","timestamp":1767907425390,"version":"3.49.0"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Coatis (Nasua nasua) are medium-sized mammals of the family Procyonidae, native of South America, characterized by an elongated nose and a long tail with alternating light and dark rings. The Instituto Chico Mendes de Conserva\u00e7\u00e3o da Biodiversidade (ICMBio) plays a crucial role in preserving this and other species within the Igua\u00e7u National Park, where animal capture for tracking, data collection, and medical interventions is performed. In this context, ensuring an effective sedation method is critical. This study aimed to compare the effects of two sedation protocols (dexmedetomidine-ketamine and tiletamine-zolazepam) in coatis, assessing their efficacy and safety. Fourteen free-ranging South American Coatis (Nasua nasua) were captured and randomly assigned for sedation with dexmedetomidine-ketamine (6.0 \u00b5g kg-1 and 15 mg kg-1, respectively; group DK) or with tiletamine-zolazepam (7.0 mg kg-1; group TZ) administered in the semimembranosus muscle of the pelvic limb. Physiological variables, such as heart rate, respiratory rate, noninvasive systolic arterial pressure, hemoglobin oxygen saturation, and rectal temperature, were recorded every five minutes since the application. The duration of sedation and quality of recovery was evaluated. Atipamezole was administered for reversal when considered necessary. Data analysis was performed using the t test. Significance was set at p&lt;0.05. In this study, no cases of regurgitation or vomit were observed. The results indicated significant differences in the heart rates between the groups, with group DK exhibiting lower values than group TZ. The average duration of sedation varied between groups, with animals in the group DK exhibiting an average sedation duration of 15 minutes, while animals in group TZ averaged 30 minutes. Notably, only one animal in group DK did not necessitate a new medication dose, while two required reversal. The tiletamine-zolazepam protocol demonstrated superior sedative efficacy in coatis compared to the dexmedetomidine-ketamine protocol, exhibiting enhanced maintenance of physiological parameters, prolonged sedation duration and improved recovery outcomes.<\/jats:p>","DOI":"10.1590\/1519-6984.289172","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:55:06Z","timestamp":1739530506000},"source":"Crossref","is-referenced-by-count":1,"title":["Sedative protocols for the restraint of coatis (Nasua nasua) for management and monitoring"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-6435","authenticated-orcid":false,"given":"M.","family":"Marangoni","sequence":"first","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1386-5026","authenticated-orcid":false,"given":"V. E.","family":"Mamgue","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7154-1822","authenticated-orcid":false,"given":"A. G.","family":"Felichak","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3530-6488","authenticated-orcid":false,"given":"M. T.","family":"Lemes","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1905-9233","authenticated-orcid":false,"given":"A. L. R.","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6382-0470","authenticated-orcid":false,"given":"M. S. P.","family":"Bellucci","sequence":"additional","affiliation":[{"name":"Instituto Chico Mendes de Conserva\u00e7\u00e3o da Biodiversidade,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0188-3402","authenticated-orcid":false,"given":"C. M.","family":"Parola","sequence":"additional","affiliation":[{"name":"Instituto Chico Mendes de Conserva\u00e7\u00e3o da Biodiversidade,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5519-061X","authenticated-orcid":false,"given":"P. H.","family":"Braz","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.vaa.2021.02.003","article-title":"Comparison of the effects of butorphanol-midazolam-medetomidine and butorphanol-azaperone-medetomidine in wild common palm civets (Paradoxurus musangus)","volume":"48","author":"AHMAD A.A.","year":"2021","journal-title":"Veterinary Anaesthesia and Analgesia"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.vaa.2019.06.003","article-title":"Immobilization of captive Persian fallow deer (Dama dama mesopotamica) using medetomidine-ketamine or medetomidine-midazolam","volume":"46","author":"AVNI-MAGEN N.","year":"2019","journal-title":"Veterinary Anaesthesia and Analgesia"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.theriogenology.2009.01.003","article-title":"Use of two anesthetic combinations for semen collection by electroejaculation from captive coatis (Nasua nasua).","volume":"71","author":"BARROS F.F.P.C.","year":"2009","journal-title":"Theriogenology"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1590\/S1519-69842001000400020","article-title":"Notes on the coati, Nasua nasua (Carnivora: Procyonidae) in an Atlantic forest area","volume":"61","author":"BEISIEGEL B.M.","year":"2001","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.7589\/2016-02-045","article-title":"Chemical Restraint of Free-ranging South American Coatis (Nasua nasua) with a Combination of Tiletamine and Zolazepam","volume":"53","author":"CONFORTI V.A.","year":"2017","journal-title":"Journal of Wildlife Diseases"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1590\/S1519-69842009000500002","article-title":"Group composition and activity patterns of brown-nosed coatis in savanna fragments, Mato Grosso do Sul, Brazil","volume":"69","author":"COSTA E.M.J.","year":"2009","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"key":"ref7","series-title":"Canine and feline anesthesia and co-existing disease.","first-page":"310","volume-title":"Neonatal, pediatric, and geriatric concerns.","author":"CUNHA A.F.","year":"2015","edition":"1st"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7589\/0090-3558-25.2.169","article-title":"Yohimbine reversal of ketamine-xylazine immobilization of raccoons (Procyon lotor)","volume":"25","author":"DERESIENSKI D.T.","year":"1989","journal-title":"Journal of Wildlife Diseases"},{"key":"ref9","series-title":"Anestesia em c\u00e3es e gatos.","first-page":"151","volume-title":"Medica\u00e7\u00e3o pr\u00e9-anest\u00e9sica.","author":"FANTONI D.T.","year":"2002","edition":"1\u00aa"},{"issue":"5538","key":"ref10","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1126\/science.1061967","article-title":"Effects of size and temperature on metabolic rate","volume":"293","author":"GILLOOLY J.F.","year":"2001","journal-title":"Science"},{"key":"ref11","series-title":"Zoo animal and wildlife immobilization and anesthesia.","first-page":"607","volume-title":"Procyonids and mustelids.","author":"KOLLIAS G.V.","year":"2014"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/BF03547317","article-title":"Ketamine, Telazol\u00ae, Xylazine and Detomidine: a comparative anesthetic drug combinations study in ponies","volume":"33","author":"LIN H.C.","year":"1992","journal-title":"Acta Veterinaria Scandinavica"},{"key":"ref13","series-title":"Manual of small animal anaesthesia and analgesia.","first-page":"71","volume-title":"Premedication and Sedation.","author":"LUKASIK V.","year":"1999"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.7589\/0090-3558-40.3.533","article-title":"Effectiveness of antagonists for tiletamine-zolazepam\/xylazine immobilization in female white-tailed deer","volume":"40","author":"MILLER B.F.","year":"2004","journal-title":"Journal of Wildlife Diseases"},{"key":"ref15","series-title":"Conten\u00e7\u00e3o qu\u00edmica com dexmedetomidina associada \u00e0 cetamina em quatis (Nasua nasua) e a revers\u00e3o dos efeitos sedativos pela ioimbina e o atipamezole.","author":"RASSY F.B.","year":"2010"},{"key":"ref16","year":"2024"},{"issue":"11","key":"ref17","first-page":"885","article-title":"A review of the physiological effects of alpha2-agonists related to the clinical use of medetomidine in small animal practice","volume":"44","author":"SINCLAIR M.D.","year":"2003","journal-title":"The Canadian Veterinary Journal. La Revue Veterinaire Canadienne"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"468","DOI":"10.7589\/0090-3558-38.2.468","article-title":"Partial antagonism of tiletamine-zolazepam anesthesia in cheetah","volume":"38","author":"WALZER C.","year":"2002","journal-title":"Journal of Wildlife Diseases"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Protocolos sedativos para conten\u00e7\u00e3o de quatis (Nasua nasua) para manejo e monitoramento"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100108&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T10:55:13Z","timestamp":1739530513000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100108&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":18,"alternative-id":["S1519-69842025000100108"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.289172","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e289172"}}