{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:57Z","timestamp":1787023077138,"version":"build-2736575974"},"reference-count":59,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract A current study investigated the effects of smoking (Cigarettes and Water-pipes) on the lung and cardiac ventricles by comparing the cytotoxic effects of smoking with certain natural antioxidants. 56 male albino rats were randomly assigned to 7 groups (N = 8 per group). Group 1 was a negative control that was exposed to fresh air; Group 2 was a positive group exposed to the most popular cigarette brands in the Jordanian market (red LM cigarettes) for 30 consecutive days, one cigarette per rat. Groups 3 and 4 were exposed to a cigarette smoking treatment with one of the natural antioxidants (vitamin C, Ammi Visnagia seed extract, respectively). Rats in group 5 were exposed to flavored water-pipe smoke resulting from the complete burning of 20 g from one coastal for 30 days, one session a day, and groups 6\u20137 were exposed to cigarette smoking with treatment with one of the selected natural antioxidants (Ascorbic acid vitamin C, Ammi Visnagia seed extract). According to immunohistochemistry investigations, smoking exposure has been linked to negative tissue consequences. Both types of smoking models induced the expression of the p53 protein in heart and lung tissues. However, p53 was mildly expressed in the heart and considerably in the lung. In conclusion, investigations were conducted on the impact of smoking on different levels, such as histological changes in the trachea, lung, and heart ventricle, as well as its influence on the expression of the p53 protein. The administration of Ammi Visnaga seed extract and Ascorbic acid exhibited protective effects against the detrimental effects of smoking through all the aforementioned methods.<\/jats:p>","DOI":"10.1590\/1519-6984.290032","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:13:35Z","timestamp":1745964815000},"source":"Crossref","is-referenced-by-count":1,"title":["Ameliorating effects of Ascorbic acid and Ammi Visnaga seeds on cigarette and water- pipe smoking Cytotoxicity in the lung and heart ventricle"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4948-1899","authenticated-orcid":false,"given":"A. A.","family":"Alsarhan","sequence":"first","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8562-4848","authenticated-orcid":false,"given":"J. D.","family":"Al-Shawabkeh","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-3851","authenticated-orcid":false,"given":"N. M. F.","family":"Abu Laban","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6305-4709","authenticated-orcid":false,"given":"S. K.","family":"Ababnheh","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-3728","authenticated-orcid":false,"given":"Z.","family":"Shraideh","sequence":"additional","affiliation":[{"name":"University of Jordan,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8117-1762","authenticated-orcid":false,"given":"D.","family":"Badran","sequence":"additional","affiliation":[{"name":"University of Jordan,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1871-7815","authenticated-orcid":false,"given":"O.","family":"Odat","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-8833","authenticated-orcid":false,"given":"G.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-6613","authenticated-orcid":false,"given":"A. K.","family":"Alkhawaldeh","sequence":"additional","affiliation":[{"name":"Al-Balqa Applied University,  Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-7865","authenticated-orcid":false,"given":"N.","family":"Sultana","sequence":"additional","affiliation":[{"name":"Prairie View A&M University,  US"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"2","key":"ref1","first-page":"120","article-title":"Ameliorative effect of vitamin C on nicotine-induced histological and ultrastructural changes in zona fasciculata in albino rats","volume":"5","author":"ABDEL-HAMID G.A.","year":"2018","journal-title":"MOJ Anatomy & Physiology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s42269-024-01174-6","article-title":"Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting","volume":"48","author":"ADDISSOUKY T.A.","year":"2024","journal-title":"Bulletin of the National Research Center"},{"key":"ref3","article-title":"Investigating the hepato-protective properties of chamomile oil and olive leaves extracts against ribociclib-induced hepatotoxicity","volume":"84","author":"ALSARHAN A.A.","year":"2024","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"June","key":"ref4","first-page":"999","article-title":"Levels of expression of Hsp70 and iNOS and effect of Artemisia Sieberi (A. herba-alba) on activity of Hypothalamic-Pituitary-Thyroid (HPT)","volume":"17","author":"ALSARHAN A.A.","year":"2024","journal-title":"Axis in Diabetic Rats."},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/plants6040042","article-title":"Phytochemicals: Extraction, isolation, and identification of bioactive compounds from plant extracts","volume":"6","author":"ALTEMIMI A.","year":"2017","journal-title":"Plants"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.20964\/2019.07.02","article-title":"Influence of phenolic compounds on antioxidant and anticorrosion activities of Ammi visnaga extracts obtained ultrasonically in three solvent systems","volume":"14","author":"AOURABI S.","year":"2019","journal-title":"International Journal of Electrochemical Science"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.tplants.2010.07.003","article-title":"Vitamins in plants: occurrence, biosynthesis and antioxidant function","volume":"15","author":"ASENSI-FABADO M.A.","year":"2010","journal-title":"Trends in Plant Science"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1017\/S0954422421000093","article-title":"Antioxidants in smokers","volume":"35","author":"ASTORI E.","year":"2022","journal-title":"Nutrition Research Reviews"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026062","article-title":"Tumor-suppressor functions of the TP53 pathway","volume":"6","author":"AUBREY B.J.","year":"2016","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"14","key":"ref10","doi-asserted-by":"crossref","first-page":"6884","DOI":"10.1016\/S0021-9258(18)68727-7","article-title":"Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance","volume":"263","author":"BECKMAN J.S.","year":"1988","journal-title":"The Journal of Biological Chemistry"},{"key":"ref11","series-title":"Public health implications of raising the minimum age of legal access to tobacco products.","volume-title":"The effects of tobacco use on health.","author":"BONNIE R.J.","year":"2015"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/978-94-017-9211-0_18","article-title":"The role of tumor suppressor p53 in the antioxidant defense and metabolism","volume":"85","author":"BUDANOV A.V.","year":"2014","journal-title":"Sub-Cellular Biochemistry"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.2196\/45313","article-title":"A series of remote melatonin supplement interventions for poor sleep: protocol for a feasibility pilot study for a series of personalized (N-of-1) trials","volume":"12","author":"BUTLER M.","year":"2023","journal-title":"JMIR Research Protocols"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","DOI":"10.1080\/10872981.2020.1798088","article-title":"Effect of the COVID-19 pandemic on medical student career perceptions: a national survey study","volume":"25","author":"BYRNES Y.M.","year":"2020","journal-title":"Medical Education Online"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1038\/s41598-018-23425-z","article-title":"Tobacco-Free cigarette smoke exposure induces anxiety and panic-related behaviours in male wistar rats","volume":"8","author":"CH\u00cdRICO M.T.T.","year":"2018","journal-title":"Scientific Reports"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1177\/1721727X231207720","article-title":"The effect of cigarette smoke exposure on rat\u2019s spermatogenesis: A systematic literature review and meta-analysis","volume":"21","author":"DJUARTINA T.","year":"2023","journal-title":"European Journal of Inflammation"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/0031-9422(93)85365-X","article-title":"Coumarins and coumarin glucosides from the fruits of Ammi majus","volume":"34","author":"ELGAMAL M.H.A.","year":"1993","journal-title":"Phytochemistry"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1093\/jmcb\/mju049","article-title":"Cigarette smoke-induced cell cycle arrest in spermatocytes [GC-2spd (ts)] is mediated through crosstalk between Ahr\u2013Nrf2 pathway and MAPK signaling","volume":"7","author":"ESAKKY P.","year":"2015","journal-title":"Journal of Molecular Cell Biology"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.4161\/oxim.3.3.12106","article-title":"Oxidative stress and autophagy in cardiac disease, neurological disorders, aging and cancer","volume":"3","author":"ESSICK E.E.","year":"2010","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43042-020-00089-x","article-title":"Exploring the multiple roles of guardian of the genome: P53","volume":"21","author":"FEROZ W.","year":"2020","journal-title":"The Egyptian Journal of Medical Human Genetics"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2147\/COPD.S42414","article-title":"COPD: balancing oxidants and antioxidants","volume":"10","author":"FISCHER B.M.","year":"2015","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"issue":"1","key":"ref22","first-page":"58","article-title":"The effect of hydroalcoholic extract of Cichorium intybus leaf on aryl hydrocarbon receptor expression in the testis of Wistar rats exposed to cigarette smoke","volume":"13","author":"HASHEMI M.","year":"2023","journal-title":"Avicenna Journal of Phytomedicine"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"E36","DOI":"10.1161\/01.RES.86.2.e36","article-title":"Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase","volume":"86","author":"HEITZER T.","year":"2000","journal-title":"Circulation Research"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","DOI":"10.3390\/antiox13030312","article-title":"Reactive oxygen species signaling and oxidative stress: transcriptional regulation and evolution","volume":"13","author":"HONG Y.","year":"2024","journal-title":"Antioxidants"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ajme.2017.09.001","article-title":"First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): their fundamental role in the entire antioxidant defence grid","volume":"54","author":"IGHODARO O.M.","year":"2018","journal-title":"Alexandria Journal of Medicine"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3390\/antiox11020347","article-title":"Chemical composition and antioxidant activity of Ammi visnaga L. essential oil","volume":"11","author":"KAMAL F.Z.","year":"2022","journal-title":"Antioxidants"},{"issue":"8","key":"ref27","first-page":"993","article-title":"Comparative study of serum MDA and vitamin C levels in non-smokers, chronic smokers and chronic smokers with acute myocardial infarction in men","volume":"16","author":"KASHINAKUNTI S.V.","year":"2011","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1023\/A:1020526517097","article-title":"Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah)","volume":"33","author":"KHAN Z.A.","year":"2001","journal-title":"International Urology and Nephrology"},{"issue":"1","key":"ref29","first-page":"1","article-title":"Protective effect against oxidative stress in medicinal plant extracts","volume":"25","author":"KIM J.H.","year":"2015","journal-title":"Journal of Radiation Protection"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1038\/s41598-023-30988-z","article-title":"Smoking and passive smoking increases mortality through mediation effect of cadmium exposure in the United States","volume":"13","author":"KIM J.","year":"2023","journal-title":"Scientific Reports"},{"key":"ref31","article-title":"The role of p53 in male infertility","volume":"15","author":"LI J.","year":"2024","journal-title":"Frontiers in Endocrinology"},{"key":"ref32","article-title":"Functional role of p53 in the regulation of chemical-induced oxidative stress","volume":"2020","author":"LIU X.","year":"2020","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00109-011-0735-5","article-title":"Metabolic regulation by p53","volume":"89","author":"MADDOCKS O.D.K.","year":"2011","journal-title":"Journal of Molecular Medicine"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0189928","article-title":"Brand switching and toxic chemicals in cigarette smoke: A national study","volume":"13","author":"MENDEL J.R.","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1134\/S1062359023600241","article-title":"Antioxidant and Antifungal Activities of Ammi visnaga Aqueous Extract Prevent Oxidative Stress Biomarkers and DNA Damage in Experimental Rats Infected with Aspergillus glaucus","volume":"50","author":"MOHAMED Z.","year":"2023","journal-title":"The Biological Bulletin"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.3390\/ijms17081328","article-title":"Vitamin C and heart health: a review based on findings from epidemiologic studies","volume":"17","author":"MOSER M.A.","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"issue":"10","key":"ref37","article-title":"Knowledge, attitude, and practice of cigarette smoking among medical students of quaid-e-azam medical college, bahawalpur: a web-based cross-sectional study","volume":"15","author":"MUSTAFA N.","year":"2023","journal-title":"Cureus"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","DOI":"10.3390\/app13106321","article-title":"Protective effects of Aquilaria agallocha and Aquilaria malaccensis edible plant extracts against lung cancer, inflammation, and oxidative stress: In Silico and In Vitro study","volume":"13","author":"NAHAR J.","year":"2023","journal-title":"Applied Sciences"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"765","DOI":"10.3390\/ijms19030765","article-title":"Dietary plants for the prevention and management of kidney stones: preclinical and clinical evidence and molecular mechanisms","volume":"19","author":"NIRUMAND M.C.","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"63","DOI":"10.5897\/JVMAH2013.0245","article-title":"Spermatozoa morphology and characteristics of Spondias mombin L.(Anacardiaceae) protected male Wistar rats exposed to sodium arsenite","volume":"6","author":"OLA-DAVIES O.","year":"2014","journal-title":"Journal of Veterinary Medicine and Animal Health"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3390\/toxics9110316","article-title":"Cigarette smoke extract produces superoxide in aqueous media by reacting with bicarbonate","volume":"9","author":"PARK J.-M.","year":"2021","journal-title":"Toxics"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.2147\/COPD.S119485","article-title":"The administration of a high refined carbohydrate diet promoted an increase in pulmonary inflammation and oxidative stress in mice exposed to cigarette smoke","volume":"11","author":"PENA K.B.","year":"2016","journal-title":"International Journal of Chronic Obstructive Pulmonary Disease"},{"key":"ref43","first-page":"405","author":"PETROVI\u0106 A.","year":"2023"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3892\/mmr.2015.4495","article-title":"Melatonin attenuates hypertension-induced renal injury partially through inhibiting oxidative stress in rats","volume":"13","author":"QIAO Y.-F.","year":"2016","journal-title":"Molecular Medicine Reports"},{"issue":"8","key":"ref45","first-page":"44","article-title":"The comparison of the effect of origanum vulgar aqueous extract and vitamin C on the control of cadmium chloride damage in testicular tissue in male rats","volume":"20","author":"RAEESZADEH M.","year":"2018","journal-title":"Majallah-i Danishgah-i Ulum-i Pizishki-i Babul"},{"issue":"1","key":"ref46","article-title":"The antioxidant properties of Alfalfa (Medicago sativa L.) and its biochemical, antioxidant, anti-inflammatory, and pathological effects on nicotine-induced oxidative stress in the rat liver","volume":"2022","author":"RAEESZADEH M.","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1111\/bph.13622","article-title":"The potential health effects of dietary phytoestrogens","volume":"174","author":"RIETJENS I.M.C.M.","year":"2017","journal-title":"British Journal of Pharmacology"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1186\/2193-1801-2-404","article-title":"Involvement of free radicals in breast cancer","volume":"2","author":"R\u00cdOS-ARRABAL S.","year":"2013","journal-title":"SpringerPlus"},{"issue":"3","key":"ref49","first-page":"100","article-title":"Evaluation of antioxidant activity of tea blends formulated using pineapple peels, ginger and lemon grass","volume":"8","author":"SAMOH F.","year":"2024","journal-title":"FUW Trends in Science & Technology Journal"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"8874","DOI":"10.1038\/s41598-020-65813-4","article-title":"Determining correlates of the average number of cigarette smoking among college students using count regression models","volume":"10","author":"SHARAREH P.","year":"2020","journal-title":"Scientific Reports"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"188","DOI":"10.21767\/2386-5180.1000188","article-title":"Male infertility; evidences, risk factors, causes, diagnosis and management in human","volume":"5","author":"SHARMA A.","year":"2017","journal-title":"Annals of Clinical and Laboratory Research"},{"issue":"4","key":"ref52","first-page":"219","article-title":"Histological changes in tissues of trachea and lung alveoli of albino rats exposed to the smoke of two types of narghile tobacco products","volume":"4","author":"SHRAIDEH Z.A.","year":"2011","journal-title":"Jordan Journal of Biological Sciences"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3945\/an.112.002154","article-title":"Health benefits of fruits and vegetables","volume":"3","author":"SLAVIN J.L.","year":"2012","journal-title":"Advances in Nutrition"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3390\/cosmetics8040111","article-title":"Apiaceae as an important source of antioxidants and their applications","volume":"8","author":"THIVIYA P.","year":"2021","journal-title":"Cosmetics"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/medicines5030093","article-title":"Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview","volume":"5","author":"TUNGMUNNITHUM D.","year":"2018","journal-title":"Medicines"},{"issue":"4","key":"ref56","article-title":"Catalases induction in high virulence pinewood nematode Bursaphelenchus xylophilus under hydrogen peroxide-induced stress","volume":"10","author":"VICENTE C.S.L.","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a026120","article-title":"Autophagy and p53","volume":"6","author":"WHITE E.","year":"2016","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"key":"ref58","article-title":"The Ciji-Hua\u2019ai-Baosheng II formula attenuates chemotherapy-induced anorexia in mice With H22 hepatocellular carcinoma","volume":"12","author":"XI S.","year":"2021","journal-title":"Frontiers in Pharmacology"},{"issue":"21","key":"ref59","doi-asserted-by":"crossref","first-page":"11659","DOI":"10.3390\/ijerph182111659","article-title":"Effect of water-pipe smoking on the normal development of zebrafish","volume":"18","author":"ZAKARIA Z.Z.","year":"2021","journal-title":"International Journal of Environmental Research and Public Health"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Efeitos ben\u00e9ficos do \u00e1cido asc\u00f3rbico e das sementes de Ammi Visnaga na citotoxicidade do fumo de cigarro e narguil\u00e9 nos pulm\u00f5es e ventr\u00edculo e card\u00edaco"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100158&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T22:13:57Z","timestamp":1745964837000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100158&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":59,"alternative-id":["S1519-69842025000100158"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.290032","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e290032"}}