{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T08:14:59Z","timestamp":1793952899156,"version":"4.8.0"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Parkinson\u2019s disease (PD) is characterized by progressive loss of dopaminergic neurons in the substantia nigra pars compacta, which leads to a reduction in the production of dopamine. Medication with levodopa becomes less effective as the disease progresses. Despite the excellent results observed in clinical practice with the medicinal use of Cannabis in the treatment of PD, the level of scientific evidence is still limited due to the small number of studies published in this field. We present the case of a 77-year-old man diagnosed 22 years ago with PD in an advanced stage, with significant bradykinesia, tremor, and rigidity along with the inability to maintain an upright position and walk, exacerbated by a femur fracture. He also had advanced dysphagia, resulting in a gastrostomy. Although lucid, he showed no interest in conversation and tended to become depressed and isolated. He used Prolopa\u00ae with no satisfactory therapeutic response. After starting treatment with Cannabis sativa oil, he is now able to walk around the house frequently and eat pasty food regularly without choking or broncho-aspiration episodes. There has also been a significant improvement in non-motor symptoms; he is more active, cheerful, communicative, and attentive to his surroundings. Further studies are needed to elucidate these results and the mechanisms of action of cannabinoids through which they exert possible neuroprotective and neuroreparative effects. These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson's disease.<\/jats:p>","DOI":"10.1590\/1519-6984.290305","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:39:39Z","timestamp":1737117579000},"source":"Crossref","is-referenced-by-count":3,"title":["Cannabis oil in treating Parkinson\u2019s disease: improvement of motor and non-motor symptoms: a case report"],"prefix":"10.1590","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8045-5043","authenticated-orcid":false,"given":"C. T. M. I.","family":"Issa","sequence":"first","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-7376","authenticated-orcid":false,"given":"R. D.","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-5653","authenticated-orcid":false,"given":"K. L. G. D.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1365-2990.2011.01248.x","article-title":"\u03949-tetrahydrocannabinol (\u03949-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease","volume":"38","author":"CARROLL C.B.","year":"2012","journal-title":"Neuropathology Applied Neurobiology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/mds.27386","article-title":"Motor and nonmotor complications of Levodopa: phenomenology, risk factors, and imaging features","volume":"33","author":"CHAUDHURI K.R.","year":"2018","journal-title":"Movement Disorders"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1007\/s12035-020-02054-6","article-title":"Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson\u2019s and Alzheimer\u2019s diseases: a review","volume":"57","author":"COORAY R.","year":"2020","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1159\/000503864","article-title":"Neurological improvement with medical cannabis in a progressive supranuclear palsy patient: a case report","volume":"2","author":"HOUNIE A.G.","year":"2019","journal-title":"Medical Cannabis and Cannabinoids"},{"key":"ref5","article-title":"Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities","volume":"89","author":"MOCK E.D.","year":"2023","journal-title":"Progress in Lipid Research"},{"issue":"16","key":"ref6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2147\/NDT.S203782","article-title":"Cannabinoids in the treatment of epilepsy: current status and future prospects","volume":"7","author":"MORANO A.","year":"2020","journal-title":"Neuropsychiatric Disease and Treatment"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"872","DOI":"10.3390\/cells8080872","article-title":"Molecular imaging of the dopamine transporter","volume":"8","author":"PALERMO G.","year":"2019","journal-title":"Cells"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1089\/jpm.2022.0343","article-title":"A case report of treatment-resistant agitation in dementia with lewy bodies: medical marijuana as an alternative to antipsychotics","volume":"26","author":"RAMM R.M.","year":"2023","journal-title":"Journal of Palliative Medicine"},{"issue":"1(Pt B)","key":"ref9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tiv.2015.11.004","article-title":"The neuroprotection of cannabidiol against MPP+-induced toxicity in PC12 cells involves trkA receptors, upregulation of axonal and synaptic proteins, neuritogenesis, and might be relevant to Parkinson's disease","volume":"30","author":"SANTOS N.A.G.","year":"2015","journal-title":"Toxicology in Vitro"},{"issue":"1-2","key":"ref10","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jns.2013.07.005","article-title":"Impact of non-motor symptoms on health-related and perceived quality of life in Parkinson\u2019s disease","volume":"332","author":"SANTOS-GARC\u00cdA D.","year":"2013","journal-title":"Journal of the Neurological Sciences"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"TOLOSA E.","year":"2021","journal-title":"Lancet Neurology"},{"issue":"2","key":"ref12","first-page":"495","article-title":"Effects of Cannabis in Parkinson\u2019s disease: a systematic review and meta-analysis","volume":"12","author":"URBI B.","year":"2022","journal-title":"Journal of Parkinson\u2019s Disorders"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.euroneuro.2007.11.003","article-title":"Therapeutic effects of Delta9-THC and modafinil in a marmoset Parkinson model","volume":"18","author":"VAN VLIET S.A.M.","year":"2008","journal-title":"European Neuropsychopharmacology"}],"container-title":["Brazilian Journal of Biology"],"original-title":["\u00d3leo de Cannabis no tratamento da doen\u00e7a de Parkinson: melhora de sintomas motores e n\u00e3o motores: relato de caso"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842024000101353&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:39:44Z","timestamp":1737117584000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842024000101353&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":13,"alternative-id":["S1519-69842024000101353"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.290305","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e290305"}}