{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:35:31Z","timestamp":1782948931233,"version":"3.54.5"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Medicinal cannabis has been the subject of extensive research, with recent studies demonstrating its potential in managing chronic pain and enhancing quality of life. This case report examines the use of medicinal cannabis in a patient treated at the School of Dentistry of Ara\u00e7atuba (FOA-UNESP). The patient, a 28-year-old female with no comorbidities, presented with chronic muscular TMD and reported poor sleep quality. Full-spectrum cannabis oil (1:1 ratio of THC to CBD), was prescribed for a period of 60 days, with a maximum dosage of 10 drops per day. Pain intensity was measured using the Visual Analog Scale (VAS), while sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Evaluations were conducted at three intervals: baseline, day 30, and day 60. To ensure patient safety, pre- and post-treatment blood tests were performed, and dosage adjustments were made every three days under the supervision of the study\u2019s medical team. The results revealed significant improvements in pain management, with the patient\u2019s orofacial pain score decreasing from 7 to 3 on the NRS. Additionally, sleep quality improved, as reflected by a lower PSQI score (global sleep quality at level 6 at the end), indicating more restorative sleep. Throughout the treatment period, the patient experienced mild side effects, including drowsiness and gastrointestinal discomfort, which were effectively managed through dosage modifications. In conclusion, full-spectrum cannabis oil shows promise as a therapeutic strategy for managing orofacial pain and improving sleep quality, providing significant relief in conditions where other interventions are ineffective or poorly tolerated. Further research is warranted to better understand the therapeutic mechanisms and potential side effects of medicinal cannabis in the management of chronic pain and related conditions.<\/jats:p>","DOI":"10.1590\/1519-6984.295805","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:09:15Z","timestamp":1760368155000},"source":"Crossref","is-referenced-by-count":2,"title":["Full Spectrum Cannabis Oil for the treatment of chronic pain and sleep dysfunction in myofascial temporomandibular disorder: a case report"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9373-0728","authenticated-orcid":false,"given":"L. V.","family":"Pinheiro","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1308-6259","authenticated-orcid":false,"given":"E. L. L.","family":"Prado","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7213-5738","authenticated-orcid":false,"given":"M. S.","family":"Januzzi","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8045-5043","authenticated-orcid":false,"given":"C. T. M. I.","family":"Issa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil; Sociedade Brasileira de Estudos de Cannabis Sativa,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9244-5653","authenticated-orcid":false,"given":"K. L. G. D.","family":"Albuquerque","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil; Sociedade Brasileira de Estudos de Cannabis Sativa,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-8198","authenticated-orcid":false,"given":"J. L. O.","family":"Schiavon","sequence":"additional","affiliation":[{"name":"Sociedade Brasileira de Estudos de Cannabis Sativa,  Brasil; Universidade Federal de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-1664","authenticated-orcid":false,"given":"E. G.","family":"Nunes","sequence":"additional","affiliation":[{"name":"Sociedade Brasileira de Estudos de Cannabis Sativa,  Brasil; Universidade de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7986-7376","authenticated-orcid":false,"given":"R. D.","family":"Castro","sequence":"additional","affiliation":[{"name":"Universidade Federal da Para\u00edba,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6381-785X","authenticated-orcid":false,"given":"F. G.","family":"Pucci","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Terap\u00eautica Cannabis Medicinal Flor da Vida,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1697-9770","authenticated-orcid":false,"given":"O. J. A.","family":"Alves","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Terap\u00eautica Cannabis Medicinal Flor da Vida,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-2029","authenticated-orcid":false,"given":"K. H. L.","family":"Turcio","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"Oct","key":"ref1","article-title":"Non-opioid psychiatric medications for chronic pain: systematic review and meta-analysis","volume":"5","author":"AYUB S.","year":"2024","journal-title":"Frontiers in Pain Research"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11920-017-0775-9","article-title":"Cannabis, cannabinoids, and sleep: a review of the literature","volume":"19","author":"BABSON K.A.","year":"2017","journal-title":"Current Psychiatry Reports"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"110","DOI":"10.9740\/mhc.2018.05.110","article-title":"Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis","volume":"8","author":"BELLNIER T.","year":"2018","journal-title":"The Mental Health Clinician"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.sleep.2010.04.020","article-title":"Validation of the Brazilian portuguese version of the Pittsburgh sleep quality index","volume":"12","author":"BERTOLAZI A.N.","year":"2011","journal-title":"Sleep Medicine"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"BUYSSE D.J.","year":"1989","journal-title":"Psychiatry Research"},{"issue":"13","key":"ref6","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1016\/j.cgh.2023.07.031","article-title":"Cannabinoids and the gastrointestinal tract","volume":"21","author":"CAMILLERI M.","year":"2023","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1093\/pm\/pnaa303","article-title":"Ingestion of a THC-Rich cannabis oil in people with fibromyalgia: a randomized, double-blind, placebo-controlled clinical trial","volume":"21","author":"CHAVES C.","year":"2020","journal-title":"Pain Medicine"},{"issue":"4","key":"ref8","first-page":"390","article-title":"Sleep disorders in patients with chronic pain: cross-sectional study","volume":"6","author":"COSTA M.S.S.","year":"2023","journal-title":"BrJP"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.drugalcdep.2014.11.031","article-title":"Experience of adjunctive cannabis use for chronic non-cancer pain: findings from the Pain and Opioids IN Treatment (POINT) study","volume":"147","author":"DEGENHARDT L.","year":"2015","journal-title":"Drug and Alcohol Dependence"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.jpain.2013.08.007","article-title":"The association of sleep and pain: an update and a path forward","volume":"14","author":"FINAN P.H.","year":"2013","journal-title":"The Journal of Pain"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1053\/j.gastro.2020.03.087","article-title":"Role of cannabis and its derivatives in gastrointestinal and hepatic disease","volume":"159","author":"GOTFRIED J.","year":"2020","journal-title":"Gastroenterology"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ejp.1118","article-title":"Efficacy, tolerability and safety of cannabis-based medicines for chronic pain management - An overview of systematic reviews","volume":"22","author":"H\u00c4USER W.","year":"2018","journal-title":"European Journal of Pain"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.684115","article-title":"Sex differences in tolerance to Delta-9-Tetrahydrocannabinol in mice with cisplatin-evoked chronic neuropathic pain","volume":"8","author":"HENDERSON-REDMOND A.N.","year":"2021","journal-title":"Frontiers in Molecular Biosciences"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s13311-015-0377-3","article-title":"Molecular targets of Cannabidiol in neurological disorders","volume":"12","author":"IBEAS BIH C.","year":"2015","journal-title":"Neurotherapeutics"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1089\/can.2016.0034","article-title":"An update on safety and side effects of cannabidiol: a review of clinical data and relevant animal studies","volume":"2","author":"IFFLAND K.","year":"2017","journal-title":"Cannabis and Cannabinoid Research"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0304-3959(86)90235-6","article-title":"Pressure-pain threshold in human temporal region: evaluation of a new pressure algometer","volume":"25","author":"JENSEN K.","year":"1986","journal-title":"Pain"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.adaj.2021.08.008","article-title":"The prevalence of comorbid chronic pain conditions among patients with temporomandibular disorders: a systematic review","volume":"153","author":"KLEYKAMP B.A.","year":"2022","journal-title":"The Journal of the American Dental Association"},{"key":"ref18","series-title":"Temporomandibular Syndrome","author":"MAINI K.","year":"2023"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21800\/S0009-67252011000200010","article-title":"A dor e os seus aspectos multidimensionais","volume":"63","author":"MARQUEZ J.O.","year":"2011","journal-title":"Ci\u00eancia e Cultura"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1037\/a0013278","article-title":"The nonpsychoactive cannabis constituent cannabidiol is a wake-inducing agent","volume":"122","author":"MURILLO-RODR\u00cdGUEZ E.","year":"2008","journal-title":"Behavioral Neuroscience"},{"issue":"S1","key":"ref21","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1038\/sj.ijo.0803272","article-title":"The pharmacology of cannabinoid receptors and their ligands: an overview","volume":"30","author":"PERTWEE R.G.","year":"2006","journal-title":"International Journal of Obesity"},{"issue":"3","key":"ref22","first-page":"e102","article-title":"Medical cannabis in patients with chronic pain: effect on pain relief, pain disability, and psychological aspects. A prospective non randomized single arm clinical trial","volume":"169","author":"POLI P.","year":"2018","journal-title":"La Clinica Terapeutica"},{"issue":"1","key":"ref23","article-title":"Medical cannabis use reduces opioid prescriptions in patients with osteoarthritis","volume":"14","author":"RENSLO B.","year":"2022","journal-title":"Cureus"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1111\/j.1476-5381.2011.01238.x","article-title":"Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects","volume":"163","author":"RUSSO E.B.","year":"2011","journal-title":"British Journal of Pharmacology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1093\/pm\/pnaa163","article-title":"Medical cannabis for the management of pain and quality of life in chronic pain patients: a prospective observational study","volume":"21","author":"SAFAKISH R.","year":"2020","journal-title":"Pain Medicine"},{"key":"ref26","series-title":"BrJP","first-page":"S49","volume-title":"Integrative approach to the therapeutic use of cannabis for orofacial pain","volume":"6","author":"TAMBELI C.H.","year":"2023"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.smrv.2005.05.002","article-title":"Sleep function and synaptic homeostasis","volume":"10","author":"TONONI G.","year":"2006","journal-title":"Sleep Medicine Reviews"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3390\/ijms19030833","article-title":"Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System","volume":"19","author":"ZOU S.","year":"2018","journal-title":"Int J Mol Sci."}],"container-title":["Brazilian Journal of Biology"],"original-title":["\u00d3leo de Cannabis Full Spectrum no tratamento da dor cr\u00f4nica e dist\u00farbios do sono em desordem temporomandibular miofascial: relato de caso"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100345&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:09:51Z","timestamp":1760368191000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100345&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":28,"alternative-id":["S1519-69842025000100345"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.295805","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e295805"}}