{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T20:32:27Z","timestamp":1767990747530,"version":"3.49.0"},"reference-count":32,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["15\/2015"],"award-info":[{"award-number":["15\/2015"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["APQ-0898-4.03\/15"],"award-info":[{"award-number":["APQ-0898-4.03\/15"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"name":"INCT_if","award":["15\/2015"],"award-info":[{"award-number":["15\/2015"]}]},{"name":"INCT_if","award":["APQ-0898-4.03\/15"],"award-info":[{"award-number":["APQ-0898-4.03\/15"]}]},{"DOI":"10.13039\/501100006162","name":"FACEPE","doi-asserted-by":"crossref","award":["15\/2015"],"award-info":[{"award-number":["15\/2015"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006162","name":"FACEPE","doi-asserted-by":"crossref","award":["APQ-0898-4.03\/15"],"award-info":[{"award-number":["APQ-0898-4.03\/15"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Immunomodulatory, antibacterial and antineoplastic activity of crude extract (CE), aqueous (AqF), and ethyl-acetate fractions (EAF) from the barks of Trichilia catigua, and cinchonain Ib EAF-isolated were investigated. CE, AqF, and EAF treatment induced significantly decreased levels of IL-6, IL-17A and IL-22 cytokines. IFN-y and IL-10 showed significant decreases after CE treatment. Cinchonain Ib significatively reduced IL-17A, IFN-y, TNF-\u03b1, IL-2 and IL-6 levels. All tested extracts and fractions showed antibacterial activity against Staphylococcus aureus and Methicillin-resistant Staphylococcus aureus (MRSA). Cinchonain Ib exhibited MIC (31.25 \u00b5g\/mL) and MBC (250 \u00b5g\/mL) against S. aureus, MRSA and S. epidermidis clinical isolate. CE and EAF treatments showed cytotoxicity in HL-60 and TOLEDO cells. EAF treatment was cytotoxic in MCF-7 cells. Cinchonain Ib presented cytotoxicity to K562 (IC50=46.21\u00b13.9), HL-60 (IC50=51.83\u00b13.17) and MOLT-4 (IC50=57.52\u00b14.57) cells. These results evidenced the availability of uses of T. catigua and cinchonain Ib as immunomodulatory, antineoplastic, bacteriostatic and bactericidal agent.<\/jats:p>","DOI":"10.1590\/1519-6984.296877","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:04:19Z","timestamp":1767971059000},"source":"Crossref","is-referenced-by-count":0,"title":["Immunomodulatory, antibacterial and antineoplastic potential of Trichilia catigua A. Juss. (Meliaceae) bark extracts and isolated compound cinchonain Ib"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8103-1076","authenticated-orcid":false,"given":"M. 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V.","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2501-3284","authenticated-orcid":false,"given":"S. D.","family":"Costa-Junior","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-3502","authenticated-orcid":false,"given":"I. M. F.","family":"Cavalcanti","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3449-493X","authenticated-orcid":false,"given":"M. R.","family":"Ritter","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. O. F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-3395","authenticated-orcid":false,"given":"J. C. P.","family":"Mello","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Maring\u00e1,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-0338","authenticated-orcid":false,"given":"M. G. R.","family":"Pitta","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1883-6012","authenticated-orcid":false,"given":"M. J. B. 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Y. Hu) H. S. Lo based on integrated ethnopharmacological data","volume":"303","author":"WANG Q.Q.","year":"2023","journal-title":"Journal of Ethnopharmacology"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbalip.2006.08.003","article-title":"Control of phospholipase A2 activities for the treatment of inflammatory conditions","volume":"1761","author":"YEDGAR S.","year":"2006","journal-title":"Biochimica et Biophysica Acta"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Potencial imunomodulador, antibacteriano e antineopl\u00e1sico dos extratos da casca de Trichilia catigua A. Juss. (Meliaceae) e do composto isolado cinchonain Ib"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100466&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T15:04:26Z","timestamp":1767971066000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100466&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":32,"alternative-id":["S1519-69842025000100466"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.296877","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e296877"}}