{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:56Z","timestamp":1787023076119,"version":"build-2736575974"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract This study aimed to evaluate adverse reactions to the bivalent foot-and-mouth disease (FMD) vaccine in beef and dairy cattle. A non-probabilistic intentional sample of 98 animals was evaluated: 48 dairy cattle (3\u201311 years old) and 50 beef cattle (18\u201322 months old; 23 males and 27 females), all clinically healthy and without previous cervical lesions. Observations were performed on days 0 (pre-vaccination), 15, 30, and 45 post-vaccination, through clinical inspection and palpation, with measurement of nodules, when present, using a caliper and\/or measuring tape. Data were analyzed using Pearson\u2019s Chi-square test (p&lt;0.05). Local vaccine reactions were recorded in 20.4% (20\/98) of animals, occurring significantly more often in dairy cattle (33%) than in beef cattle (8%). Among dairy cattle, 56.3% (9\/16) of those with abscesses were approximately 10 years old. Animals that developed lesions at the first evaluation maintained them throughout the study period. No weight loss was associated with vaccine reactions. In conclusion, although the bivalent formulation reduces adverse effects, abscess formation may still occur, highlighting the need for monitoring and the adoption of good vaccination practices.<\/jats:p>","DOI":"10.1590\/1519-6984.296922","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:01:44Z","timestamp":1761577304000},"source":"Crossref","is-referenced-by-count":2,"title":["Adverse reactions to bivalent vaccine against foot-and-mouth disease in beef and dairy cattle"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9537-7738","authenticated-orcid":false,"given":"J. M.","family":"Muniz","sequence":"first","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6775-4056","authenticated-orcid":false,"given":"H. P.","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2075-9914","authenticated-orcid":false,"given":"D. C.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3970-7524","authenticated-orcid":false,"given":"N. P. C.","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7682-8141","authenticated-orcid":false,"given":"C. J. R. M.","family":"Ros\u00e1rio","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7611-6673","authenticated-orcid":false,"given":"V. C. S.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Maranh\u00e3o \u2013 UEMA,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","series-title":"Programa de Erradica\u00e7\u00e3o e Preven\u00e7\u00e3o da Febre Aftosa no Maranh\u00e3o (PNEFA\/MA)","year":"2020"},{"key":"ref2","series-title":"Nota t\u00e9cnica n\u00ba 30\/2017: rea\u00e7\u00f5es adversas \u00e0 vacina contra febre aftosa","year":"2017"},{"key":"ref3","series-title":"Instru\u00e7\u00e3o normativa n\u00ba 44 de 2 de outubro de 2007. Disp\u00f5e sobre as diretrizes gerais para a Erradica\u00e7\u00e3o e a Preven\u00e7\u00e3o da Febre Aftosa","first-page":"2","year":"2007"},{"key":"ref4","series-title":"Instru\u00e7\u00e3o Normativa n\u00ba 11 de 18 de janeiro de 2018. Regulamento t\u00e9cnico para produ\u00e7\u00e3o, Controle da Qualidade, Comercializa\u00e7\u00e3o e Emprego de Vacinas contra a febre aftosa","first-page":"4","year":"2018"},{"key":"ref5","series-title":"Evolu\u00e7\u00e3o das zonas livres de febre aftosa no Brasil","year":"2022"},{"key":"ref6","series-title":"Portaria MAPA n\u00ba 574, de 31 de mar\u00e7o de 2023. Pro\u00edbe o armazenamento, a comercializa\u00e7\u00e3o e o uso de vacinas contra a febre aftosa no Distrito Federal e nos Estados do Esp\u00edrito Santo, Goi\u00e1s, Minas Gerais, Mato Grosso, Mato Grosso do Sul e Tocantins","first-page":"4","year":"2023"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/1981-2965.20220023","article-title":"Perdas quantitativas por rea\u00e7\u00f5es vacinais em carca\u00e7as de bovinos no Brasil","volume":"16","author":"CAETANO A.L.","year":"2022","journal-title":"Revista Brasileira de Higiene e Sanidade Animal"},{"issue":"1","key":"ref8","first-page":"14","article-title":"Febre aftosa: n\u00e3o vacina\u00e7\u00e3o ou vacina\u00e7\u00e3o incorreta e sua implica\u00e7\u00e3o no agroneg\u00f3cio","volume":"10","author":"FELIX M.O.","year":"2019","journal-title":"Tekhne e Logos"},{"key":"ref9","series-title":"Manual de Boas Pr\u00e1ticas de Vacina\u00e7\u00e3o e Imuniza\u00e7\u00e3o de Bovinos","author":"GASPAR E.B.","year":"2015"},{"key":"ref10","series-title":"Pesquisa da Pecu\u00e1ria Municipal \u2013 PPM 2022","year":"2022"},{"issue":"1-2","key":"ref11","first-page":"156","article-title":"Febre Aftosa: ocorr\u00eancia de n\u00f3dulo p\u00f3s-vacinal segundo via de aplica\u00e7\u00e3o da vacina","volume":"20","author":"LIMA D.C.P.","year":"2014","journal-title":"Pesquisa Agropecu\u00e1ria Ga\u00facha"},{"issue":"34","key":"ref12","first-page":"1","article-title":"Febre aftosa: revis\u00e3o de literatura","author":"MELO W.G.G.","year":"2020","journal-title":"Revista Cient\u00edfica de Medicina Veterin\u00e1ria"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"2812","DOI":"10.34117\/bjdv9n1-195","article-title":"Compara\u00e7\u00e3o da vacina\u00e7\u00e3o de bovinos f\u00eameas de 0 a 24 meses de idade com dosagens diferentes da vacina bivalente oleosa segundo plano nacional de erradica\u00e7\u00e3o e preven\u00e7\u00e3o de febre aftosa (PNEFA) do MAPA","volume":"9","author":"OLIVEIRA J\u00daNIOR M.P.","year":"2023","journal-title":"Brazilian Journal of Development"},{"key":"ref14","series-title":"Boas pr\u00e1ticas agropecu\u00e1rias: bovinos e bubalinos de corte: manual orientador.","author":"PEREIRA M.A.","year":"2022","edition":"3rd ed."},{"issue":"1","key":"ref15","first-page":"31","article-title":"Exporta\u00e7\u00f5es de carne bovina brasileira: uma an\u00e1lise a partir de um modelo de equil\u00edbrio geral comput\u00e1vel","volume":"15","author":"PEREIRA R.M.","year":"2019","journal-title":"Perspectiva Econ\u00f4mica"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1590\/1678-5150-pvb-6663","article-title":"Adverse effects of foot-and-mouth disease vaccine in dairy cattle","volume":"40","author":"ROBATTINI J.A.","year":"2020","journal-title":"Pesquisa Veterin\u00e1ria Brasileira"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36524\/ric.v7i1.1063","article-title":"Aplica\u00e7\u00e3o do ciclo PDCA integrado ao plano de qualifica\u00e7\u00e3o de fornecedores de leite","volume":"7","author":"SANTOS P.P.","year":"2021","journal-title":"Revista IFES Ci\u00eancia"},{"issue":"2","key":"ref18","first-page":"85","article-title":"Rea\u00e7\u00f5es adversas \u00e0 vacina\u00e7\u00e3o contra febre aftosa em bovinos: an\u00e1lise retrospectiva","volume":"22","author":"VERAN M.","year":"2000","journal-title":"Revista Brasileira de Medicina Veterin\u00e1ria"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Rea\u00e7\u00f5es adversas \u00e0 vacina bivalente contra a febre aftosa em bovinos de corte e leite"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100360&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:01:46Z","timestamp":1761577306000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100360&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":18,"alternative-id":["S1519-69842025000100360"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.296922","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e296922"}}