{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:53:02Z","timestamp":1775220782449,"version":"3.50.1"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Tooth extraction without proper socket prevention will lead to bone loss. Applying bovine amnion membrane-hydroxyapatite (BAM-HA composite) can maintain bone structure through osteoclast and woven bone formation. The purpose of the study to evaluate the different compositions of BAM-HA composite as socket preservation by analyzing osteoclast and woven bone formation. Thirty male Sprague-Dawley rats underwent lower anterior teeth extraction. Each socket treated by BAM-HA composite with different ratio or composition 30:70, 35:65, 40:60 and control group treated with BioOss collagen. Fourteen and twent-eight-days after treatment, the mandible was collected for histological analysis for osteoclast and woven bone formation using hematoxyline-eosine staining. Statistical analysis was performed using two-way ANOVA and Tukey\u2019s post-hoc test with p&lt;0.05 consider as statistical differences. BAM-HA composite treated groups showed a reduction in osteoclast numbers compared to the control and BioOss groups (p&lt;0.05), indicating a suppression of excessive bone resorption. Concurrently, BAM-HA composite-treated groups, particularly composition 30:70 and 35:65, exhibited the highest levels of woven bone formation (p&lt;0.05), suggesting enhanced bone regeneration. The application of the BAM-HA composite enhances alveolar bone regeneration in Sprague-Dawley rats tooth extraction sockets by reducing osteoclast number and promoting woven bone formation, suggesting its potential as an effective bone graft material to maintain the alveolar bone height.<\/jats:p>","DOI":"10.1590\/1519-6984.296925","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:49:32Z","timestamp":1775216972000},"source":"Crossref","is-referenced-by-count":0,"title":["Bovine amnion membrane-hydroxyapatite composite enhances alveolar bone regeneration by modulating osteoclast activity and woven bone formation"],"prefix":"10.1590","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-2380","authenticated-orcid":false,"given":"E.","family":"Munadziroh","sequence":"first","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-0243","authenticated-orcid":false,"given":"A.","family":"Yuliati","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6044-2722","authenticated-orcid":false,"given":"T. H.","family":"Agustantina","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. K.","family":"Maharani","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Halizah","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7920-8397","authenticated-orcid":false,"given":"Y. A.","family":"Azzaim","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-2287","authenticated-orcid":false,"given":"M. D. C.","family":"Surboyo","sequence":"additional","affiliation":[{"name":"Universitas Airlangga,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4021-1668","authenticated-orcid":false,"given":"N.","family":"Mohd","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia,  Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"ref1","first-page":"172","article-title":"The characteristics of swelling and biodegradation tests of bovine amniotic membrane-hydroxyapatite biocomposite","volume":"56","author":"AGUSTANTINA T.H.","year":"2023","journal-title":"Dentistry Journal"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3389\/fmed.2017.00234","article-title":"Key triggers of osteoclast-related diseases and available strategies for targeted therapies: a review","volume":"4","author":"BI 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