{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:28:04Z","timestamp":1777638484038,"version":"3.51.4"},"reference-count":21,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"PFR","award":["22100\/IT3.D10\/PT.01.03\/P\/B\/2024"],"award-info":[{"award-number":["22100\/IT3.D10\/PT.01.03\/P\/B\/2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Murraya paniculata L. is a medicinal plant traditionally used for its wide range of pharmacological properties. This study investigated the metabolite profiles and biological activities of M. paniculata leaf extracts obtained using ethanol, 50% ethanol, and water as solvents. Metabolite identification was performed using UHPLC-Q-Orbitrap HRMS, revealing 61 compounds including alkaloids, flavonoids, phenolics, terpenes, and amino acids. Antioxidant activity was evaluated via the DPPH method, yielding IC50 values of 678.84, 391.29, and 839.08 \u00b5g\/mL for ethanol, 50% ethanol, and water extracts, respectively. Lipase inhibitory activity showed highest inhibition in the water extract (59.32%), followed by 50% ethanol (45.05%) and ethanol (36.37%). Pearson\u2019s correlation analysis indicated six metabolites negatively correlated with antioxidant activity and twelve positively correlated with lipase inhibition. The dual association of 4-aminobenzoic acid with both activities underlines its pharmacological significance. These findings demonstrate the impact of solvent type on metabolite composition and biological efficacy, providing insight into the bioactive potential of M. paniculata.<\/jats:p>","DOI":"10.1590\/1519-6984.296951","type":"journal-article","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T15:04:00Z","timestamp":1762182240000},"source":"Crossref","is-referenced-by-count":2,"title":["Solvent-driven metabolite profiling and its correlation with antioxidant and lipase inhibitory activities in Murraya paniculata leaves"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7253-8262","authenticated-orcid":false,"given":"D. A.","family":"Septaningsih","sequence":"first","affiliation":[{"name":"IPB University,  Indonesia; Republic of Indonesia Defense University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5225-8703","authenticated-orcid":false,"given":"M.","family":"Rafi","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia; IPB University,  Indonesia; IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0902-5389","authenticated-orcid":false,"given":"R.","family":"Heryanto","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia; IPB University,  Indonesia; IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2175-344X","authenticated-orcid":false,"given":"S.","family":"Fauziah","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9226-7942","authenticated-orcid":false,"given":"C. N.","family":"Amanda","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6441-6070","authenticated-orcid":false,"family":"Annisa","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-5227","authenticated-orcid":false,"given":"S. A.","family":"Aziz","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia; IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6270-3356","authenticated-orcid":false,"given":"S. A.","family":"Kusumastuti","sequence":"additional","affiliation":[{"name":"National Research and Innovation Agency,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7047-5093","authenticated-orcid":false,"given":"W.","family":"Nurcholis","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia; IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-244X","authenticated-orcid":false,"given":"W. A.","family":"Kusuma","sequence":"additional","affiliation":[{"name":"IPB University,  Indonesia; IPB University,  Indonesia; IPB University,  Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/foods12030579","article-title":"Comparative untargeted metabolic profiling of different parts of Citrus sinensis fruits via liquid chromatography\u2013mass spectrometry coupled with multivariate data analyses to unravel authenticity","volume":"12","author":"AFIFI S.M.","year":"2023","journal-title":"Foods"},{"issue":"2","key":"ref2","first-page":"1","article-title":"Antioxidant and sunscreen activity from Curcuma xanthorrhizananoparticles extract","volume":"6","author":"ANARISA R.","year":"2021","journal-title":"Jurnal Jamu Indonesia"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2021.113688","article-title":"Specialized metabolite profiling of different Glycyrrhiza glabra organs by untargeted UHPLC-HRMS","volume":"170","author":"CELANO R.","year":"2021","journal-title":"Industrial Crops and Products"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0305544","article-title":"Unveiling the anti-obesity potential of Kemuning (Murraya paniculata): a network pharmacology approach","volume":"19","author":"FATRIANI R.","year":"2024","journal-title":"PLoS One"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.3390\/biomedicines11102686","article-title":"Novel para-aminobenzoic acid analogs and their potential therapeutic applications","volume":"11","author":"HAROON F.","year":"2023","journal-title":"Biomedicines"},{"issue":"2","key":"ref6","first-page":"45","article-title":"Total flavonoid content in Sauropus androgynus leaf extract at different altitudes","volume":"6","author":"HIKMAWANTI N.P.E.","year":"2021","journal-title":"Jurnal Jamu Indonesia"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3831\/KPI.2023.26.1.10","article-title":"A brief review on Murraya paniculata (orange jasmine): pharmacognosy, phytochemistry and ethanomedicinal uses","volume":"26","author":"JOSHI D.","year":"2023","journal-title":"Journal of Pharmacopuncture"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.sajb.2023.08.035","article-title":"LC-HRMS-based metabolomics of Sida rhombifolia and evaluation of its biological activity using different extracting solvent concentrations","volume":"161","author":"KAROMAH A.H.","year":"2023","journal-title":"South African Journal of Botany"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2024.464736","article-title":"A quantitative chemomics strategy for the comprehensive comparison of Murraya paniculata and M. exotica using liquid chromatography coupled with mass spectrometry","volume":"1718","author":"LIANG H.","year":"2024","journal-title":"Journal of Chromatography. 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