{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:12:20Z","timestamp":1766157140224,"version":"3.48.0"},"reference-count":65,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Diabetes mellitus is a global public health issue and, at the onset of the COVID-19 pandemic, was identified as a risk factor associated with high morbidity and mortality in cases of acute respiratory infection caused by the SARS-CoV-2 coronavirus. This study investigated genetic variants in diabetic patients with COVID-19 through a systematic analysis of the PubMed\/NCBI, EMBASE, Web of Science, SCOPUS, and Virtual Health Library databases, with the protocol registered on the PROSPERO platform (registration number CRD42020181311). Fifteen genetic variants were associated with five specific genes in symptomatic diabetic patients with COVID-19. Inheritance models, diabetic individuals carrying the heterozygous genotype TC (VDR rs4516035) showed ~10\u201315-fold higher odds of symptomatic COVID-19. Protein-protein interaction (PPI) analysis showed that the proteins ACE, ACE2, IL-6, and IL-17 exhibited strong predicted interactions with each other, as well as with insulin and the TMPRSS2 protease. Limitations include small number of eligible studies, heterogeneity in populations and outcome definitions. These preliminary findings highlight the need for further studies to understand better the relationship between the identified genetic variants and the progression of COVID-19 in diabetic patients.<\/jats:p>","DOI":"10.1590\/1519-6984.297127","type":"journal-article","created":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:03:46Z","timestamp":1766156626000},"source":"Crossref","is-referenced-by-count":0,"title":["Association of genetic variants with the progression of COVID-19 symptoms in diabetic patients: a systematic review and in silico protein interaction analysis"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-2843","authenticated-orcid":false,"given":"L. C.","family":"Silveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-3072","authenticated-orcid":false,"given":"K. F.","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6254-7250","authenticated-orcid":false,"given":"J. S.","family":"Campos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1743-8151","authenticated-orcid":false,"given":"L. P.","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9480-4362","authenticated-orcid":false,"given":"R. S.","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil; Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-7334","authenticated-orcid":false,"given":"A. A. S.","family":"Reis","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil; Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.biopha.2018.02.103","article-title":"The potential pathogenic role of IL-17\/Th17 cells in both type 1 and type 2 diabetes mellitus","volume":"101","author":"ABDEL-MONEIM A.","year":"2018","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2021.105098","article-title":"Association of Vitamin D receptor gene polymorphisms and clinical\/severe outcomes of COVID-19 patients","volume":"96","author":"ABDOLLAHZADEH R.","year":"2021","journal-title":"Infection, Genetics and Evolution"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1007\/s00134-020-06022-5","article-title":"Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)","volume":"46","author":"ALHAZZANI W.","year":"2020","journal-title":"Intensive Care Medicine"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.jiph.2020.06.021","article-title":"Role of vitamin D in preventing of COVID-19 infection, progression and severity","volume":"13","author":"ALI N.","year":"2020","journal-title":"Journal of Infection and Public Health"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/jpm11010042","article-title":"Laboratory-based resources for COVID-19 diagnostics: traditional tools and novel technologies. a perspective of personalized medicine","volume":"11","author":"ANDRYUKOV B.G.","year":"2021","journal-title":"Journal of Personalized Medicine"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00210-020-01911-4","article-title":"Vitamin D can prevent COVID-19 infection-induced multiple organ damage","volume":"393","author":"AYGUN H.","year":"2020","journal-title":"Naunyn-Schmiedeberg\u2019s Archives of Pharmacology"},{"issue":"21","key":"ref7","article-title":"COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis","volume":"120","author":"BARRETO E.A.","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"D1","key":"ref8","doi-asserted-by":"crossref","first-page":"D523","DOI":"10.1093\/nar\/gkac1052","article-title":"UniProt: the Universal Protein Knowledgebase in 2023","volume":"51","author":"BATEMAN A.","year":"2023","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"ref9","first-page":"39","article-title":"Effects of VDR polymorphisms on the COVID-19 Symptoms","volume":"33","author":"BAYRAM F.","year":"2022","journal-title":"Gazi Medical Journal"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.nfs.2020.06.001","article-title":"Vitamin D deficiency and co-morbidities in COVID-19 patients: a fatal relationship?","volume":"20","author":"BIESALSKI H.K.","year":"2020","journal-title":"Nfs Journal"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1590\/1519-6984.238155","article-title":"Fighting COVID-19","volume":"80","author":"CAMPOS D.M.O.","year":"2020","journal-title":"Brazilian Journal of Biology = Revista Brasileira de Biologia"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4238\/gmr18969","article-title":"Genetic epidemiology of Type 2 Diabetes mellitus and complications in the Brazilian population","volume":"21","author":"CAMPOS J.S.","year":"2022","journal-title":"Genetics and Molecular Research"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"E874","DOI":"10.1152\/ajpendo.00490.2012","article-title":"Pancreatic angiotensin-converting enzyme 2 improves glycemia in angiotensin II-infused mice","volume":"304","author":"CHHABRA K.H.","year":"2013","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1080\/00325481.2021.2017647","article-title":"Vitamin D and COVID-19: where are we now?","volume":"135","author":"CONTRERAS-BOL\u00cdVAR V.","year":"2023","journal-title":"Postgraduate Medicine"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.559841","article-title":"Insights on SARS-CoV-2 molecular interactions with the renin-angiotensin system","volume":"8","author":"COSTA L.B.","year":"2020","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1136\/thoraxjnl-2014-206680","article-title":"Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)","volume":"70","author":"DANCER R.C.","year":"2015","journal-title":"Thorax"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0288338","article-title":"Angiotensin-Converting Enzyme (ACE) level, but not ACE gene polymorphism, is associated with prognosis of COVID-19 infection: implications for diabetes and hypertension","volume":"18","author":"ELBASAN O.","year":"2023","journal-title":"PLoS One"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109105","article-title":"Vitamin D boosts immune response of macrophages through a regu-latory network of microRNAs and mRNAs","volume":"109","author":"FERNANDEZ G.J.","year":"2022","journal-title":"The Journal of Nutritional Biochemistry"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"720","DOI":"10.3934\/publichealth.2021057","article-title":"The underlying mechanisms for severe COVID-19 progression in people with diabetes mellitus: a critical review","volume":"8","author":"FIGUEROA-PIZANO M.D.","year":"2021","journal-title":"AIMS Public Health"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jprot.2014.04.003","article-title":"Individualized proteomics","volume":"107","author":"FORLER S.","year":"2014","journal-title":"Journal of Proteomics"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s00134-020-06033-2","article-title":"COVID-19 pneumonia: different respiratory treatments for different phenotypes?","volume":"46","author":"GATTINONI L.","year":"2020","journal-title":"Intensive Care Medicine"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.3390\/ijerph19116555","article-title":"Increased risk of COVID-19 in patients with diabetes mellitus-current challenges in pathophysiology, treatment and prevention","volume":"19","author":"G\u0118CA T.","year":"2022","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.fertnstert.2018.05.006","article-title":"Personalized medicine: motivation, challenges, and progress","volume":"109","author":"GOETZ L.H.","year":"2018","journal-title":"Fertility and Sterility"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"988","DOI":"10.3390\/nu12040988","article-title":"Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths","volume":"12","author":"GRANT W.B.","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","volume":"18","author":"HOFFMANN M.","year":"2020","journal-title":"Cell"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s40520-020-01570-8","article-title":"The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality","volume":"32","author":"ILIE P.C.","year":"2020","journal-title":"Aging Clinical and Experimental Research"},{"key":"ref27","article-title":"ACE gene variants rise the risk of severe COVID-19 in patients with hypertension, dyslipidemia or diabetes: a Spanish pilot study","volume":"12","author":"\u00cd\u00d1IGUEZ M.","year":"2021","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41580-021-00418-x","article-title":"Mechanisms of SARS-CoV-2 entry into cells","volume":"23","author":"JACKSON C.B.","year":"2022","journal-title":"Nature Reviews. Molecular Cell Biology"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev-pharmtox-010919-023711","article-title":"(Inverse) Agonists of retinoic acid\u2013related orphan receptor \u03b3: regulation of immune responses, inflammation, and autoimmune disease","volume":"60","author":"JETTEN A.M.","year":"2020","journal-title":"Annual Review of Pharmacology and Toxicology"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3233\/HAB-230007","article-title":"Evaluation of IL-6 and IL-17A gene polymorphisms in Iraqi patients infected with COVID-19 and Type 2 Diabetes Mellitus","volume":"31","author":"KHALAF Q.A.","year":"2023","journal-title":"Human Antibodies"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"m408","DOI":"10.1136\/bmj.m408","article-title":"China coronavirus: WHO declares international emergency as death toll exceeds 200","volume":"368","author":"MAHASE E.","year":"2020","journal-title":"BMJ"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"L156","DOI":"10.1152\/ajplung.00313.2002","article-title":"Angiotensin II and the fibroproliferative response to acute lung injury","volume":"286","author":"MARSHALL R.P.","year":"2004","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","article-title":"PRESS peer review of electronic search strategies: 2015 guideline statement","volume":"75","author":"MCGOWAN J.","year":"2016","journal-title":"Journal of Clinical Epidemiology"},{"issue":"10229","key":"ref34","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(20)30628-0","article-title":"COVID-19: consider cytokine storm syndromes and immunosuppression","volume":"395","author":"MEHTA P.","year":"2020","journal-title":"Lancet"},{"key":"ref35","series-title":"JBI manual for evidence synthesis.","first-page":"1","volume-title":"Explanation of analytical cross sectional studies critical appraisal","author":"MOOLA S.","year":"2020"},{"key":"ref36","series-title":"JBI manual for evidence synthesis.","volume-title":"Systematic reviews of etiology and risk","author":"MOOLA S.","year":"2020"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.3390\/jpm11111098","article-title":"Strong association of angiotensin converting enzyme-2 gene insertion\/deletion polymorphism with susceptibility to SARS-CoV-2, hypertension, coronary artery disease and COVID-19 disease mortality","volume":"11","author":"MUZAFFAR MIR M.M.","year":"2021","journal-title":"Journal of Personalized Medicine"},{"key":"ref38","series-title":"Gene","year":"2025"},{"key":"ref39","series-title":"dbSNP","year":"2025"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"OUZZANI M.","year":"2016","journal-title":"Systematic Reviews"},{"issue":"3","key":"ref41","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"18","author":"PAGE M.J.","year":"2021","journal-title":"PLoS Medicine"},{"issue":"1","key":"ref42","article-title":"Polymorphisms of the vitamin D receptor gene (FOKI, CDX2, and GATA) and susceptibility to chronic periodontitis in diabetic and non-diabetic individuals: a case-control study","volume":"10","author":"PINHO R.C.M.","year":"2019","journal-title":"Journal of Investigative and Clinical Dentistry"},{"key":"ref43","series-title":"R: a language and environment for statistical computing","year":"2022"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.3390\/ijms21051770","article-title":"Insulin: The Friend and the Foe in the Development of Type 2 Diabetes Mellitus","volume":"21","author":"RACHDAOUI N.","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00299-20","article-title":"Critical determinants of cytokine storm and Type I interferon response in COVID-19 pathogenesis","volume":"34","author":"RAMASAMY S.","year":"2021","journal-title":"Clinical Microbiology Reviews"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.746151","article-title":"Meta-Inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites","volume":"12","author":"RUSSO S.","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"154","DOI":"10.3390\/genes12020154","article-title":"Epigenetic evolution of ACE2 and IL-6 genes: non-canonical interferon-stimulated genes correlate to COVID-19 susceptibility in vertebrates","volume":"12","author":"SANG E.R.","year":"2021","journal-title":"Genes"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s12041-021-01262-w","article-title":"Contributions of human ACE2 and TMPRSS2 in determining host-pathogen interaction of COVID-19","volume":"100","author":"SENAPATI S.","year":"2021","journal-title":"Journal of Genetics"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s11010-021-04093-6","article-title":"Role of vitamin D in treating COVID-19-associated coagulopathy: problems and perspectives","volume":"476","author":"SENGUPTA T.","year":"2021","journal-title":"Molecular and Cellular Biochemistry"},{"key":"ref50","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113089","article-title":"COVID-19 and diabetes: association intensify risk factors for morbidity and mortality","volume":"151","author":"SHARMA P.","year":"2022","journal-title":"Biomedicine and Pharmacotherapy"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s40292-021-00439-9","article-title":"Angiotensin-converting-enzyme 2 and renin-angiotensin system inhibitors in COVID-19: an update","volume":"28","author":"SHUKLA A.K.","year":"2021","journal-title":"High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension"},{"key":"ref52","first-page":"18378","article-title":"ACE insertion\/deletion polymorphism and diabetic nephropathy: an evidence-based meta-analysis","volume":"18","author":"SILVEIRA L.C.","year":"2018","journal-title":"GMR"},{"issue":"1","key":"ref53","article-title":"Genetic determinants associated with the progression of COVID-19 symptoms in diabetic patients: a systematic review protocol","volume":"23","author":"SILVEIRA L.C.","year":"2024","journal-title":"Genetics and Molecular Research"},{"issue":"15","key":"ref54","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","article-title":"SNPStats: a web tool for the analysis of association studies","volume":"22","author":"SOL\u00c9 X.","year":"2006","journal-title":"Bioinformatics"},{"key":"ref55","series-title":"STRING version 12.0","year":"2025"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coph.2017.12.002","article-title":"Targeting the renin-angiotensin system as novel therapeutic strategy for pulmonary diseases","volume":"40","author":"TAN W.S.D.","year":"2018","journal-title":"Current Opinion in Pharmacology"},{"key":"ref57","article-title":"The role of vitamin D in the relationship between gender and deep vein thrombosis among stroke patients","volume":"8","author":"TAO J.","year":"2021","journal-title":"Frontiers in Nutrition"},{"issue":"19","key":"ref58","first-page":"7015","article-title":"Relationship between vitamin D deficiency and thrombus load in patients with ST-elevation myocardial infarction","volume":"26","author":"UGUZ B.","year":"2022","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"ref59","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2021.104801","article-title":"Impact of I\/D polymorphism of angiotensin-converting enzyme 1 (ACE1) gene on the severity of COVID-19 patients","volume":"91","author":"VERMA S.","year":"2021","journal-title":"Infection, Genetics and Evolution"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/JLB.3COVR0520-272R","article-title":"Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts","volume":"108","author":"WANG J.","year":"2020","journal-title":"Journal of Leukocyte Biology"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5492\/wjccm.v11.i2.112","article-title":"Potential role of vitamin D in patients with diabetes, dyslipidaemia, and COVID-19","volume":"11","author":"WANG M.K.","year":"2022","journal-title":"World Journal of Critical Care Medicine"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.7861\/clinmed.2020-0301","article-title":"Does vitamin D deficiency increase the severity of COVID-19?","volume":"20","author":"WEIR E.K.","year":"2020","journal-title":"Clinical Medicine"},{"key":"ref63","series-title":"Coronavirus (COVID-19) dashboard","year":"2019"},{"key":"ref64","series-title":"Clinical management of COVID-19: living guideline","year":"2022"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijid.2020.03.071","article-title":"Insight into 2019 novel coronavirus: an updated interim review and lessons from SARS-CoV and MERS-CoV","volume":"94","author":"XIE M.","year":"2020","journal-title":"International Journal of Infectious Diseases"}],"container-title":["Brazilian Journal of Biology"],"original-title":["Associa\u00e7\u00e3o de variantes gen\u00e9ticas com a progress\u00e3o dos sintomas de COVID-19 em pacientes diab\u00e9ticos: uma revis\u00e3o sistem\u00e1tica e an\u00e1lise de intera\u00e7\u00e3o de prote\u00ednas in silico"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1519-69842025000100452&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T15:03:56Z","timestamp":1766156636000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1519-69842025000100452&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":65,"alternative-id":["S1519-69842025000100452"],"URL":"https:\/\/doi.org\/10.1590\/1519-6984.297127","relation":{},"ISSN":["1678-4375","1519-6984"],"issn-type":[{"value":"1678-4375","type":"electronic"},{"value":"1519-6984","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e297127"}}