{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:21:24Z","timestamp":1780597284941,"version":"3.54.1"},"reference-count":120,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract Neurodegenerative diseases (NDs) such as Alzheimer\u2019s, Parkinson\u2019s, Huntington\u2019s disease, and amyotrophic lateral sclerosis are escalating worldwide, straining healthcare systems and leaving patients with therapies that are largely palliative. Emerging evidence positions diversified ultraviolet (UV) irradiation as a groundbreaking, non-invasive strategy to counter these disorders. Beyond its traditional use in sterilization, specific UV spectra, UV-B (280\u2013320 nm), UV-C (200\u2013280 nm), and far-UV (207\u2013222 nm), are now recognized for modulating oxidative stress, restoring mitochondrial function, correcting apoptotic dysregulation, and enhancing DNA repair. Innovative approaches such as riboflavin-mediated phototherapy and photobiomodulation (PBM) show the capacity to disaggregate toxic protein aggregates like \u03b2-amyloid and \u03b1-synuclein, boost antioxidant defenses, stimulate neurotrophic factors, and quell neuroinflammation. Preclinical models and early clinical trials reveal preserved cognition, enhanced neurogenesis, and reduced disease biomarkers, suggesting real translational promise. From a public-health perspective, UV-based interventions offer a cost-effective, scalable option for aging populations and resource-limited settings, especially when integrated with community-level health technologies and remote delivery platforms. Continued investigation of optimal dosing, long-term safety, and mechanistic pathways will be pivotal to unlock the full therapeutic and population-wide impact of this novel modality.<\/jats:p>","DOI":"10.1590\/1519-6984.297765","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T13:14:43Z","timestamp":1768310083000},"source":"Crossref","is-referenced-by-count":2,"title":["Innovative public-health strategies for neurodegenerative disease: leveraging diversified ultraviolet irradiation as a next-generation therapy"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-2853-2054","authenticated-orcid":false,"given":"M.","family":"Khan","sequence":"first","affiliation":[{"name":"Kunming Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9740-0371","authenticated-orcid":false,"given":"U.","family":"Saeed","sequence":"additional","affiliation":[{"name":"Near East University,  Turkey; Clinical and Biomedical Research Center,  Pakistan; Sz\u00e9chenyi Istv\u00e1n University,  Hungary; University College, Korea University,  Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Z.","family":"Piracha","sequence":"additional","affiliation":[{"name":"International Center of Medical Sciences Research,  USA; International Center of Medical Sciences Research,  Pakistan; International Center of Medical Sciences Research,  United Kingdom; Riphah International University,  Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ozsahin","sequence":"additional","affiliation":[{"name":"Near East University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4915-5962","authenticated-orcid":false,"given":"C.","family":"Shao-Chun","sequence":"additional","affiliation":[{"name":"Kunming Medical University,  China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"18","key":"ref1","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1089\/ars.2017.7099","article-title":"Redox signaling, neuroinflammation, and neurodegeneration","volume":"28","author":"AGUILERA G.","year":"2018","journal-title":"Antioxidants & Redox Signaling"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.bbagen.2017.01.018","article-title":"Mechanism of ROS scavenging and antioxidant signalling by redox metallic and fullerene nanomaterials: potential implications in ROS associated degenerative disorders","volume":"1861","author":"AKHTAR M.J.","year":"2017","journal-title":"Biochimica et Biophysica Acta. 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