{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:11:58Z","timestamp":1780096318009,"version":"3.54.0"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["301911\/2022-3"],"award-info":[{"award-number":["301911\/2022-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Braz. J. Biol."],"abstract":"<jats:p>Abstract This study investigated, for the first time, the efficacy against Anacanthorus spathulatus, Notozothecium janauachensis, and Mymarothecium boegeri of solid lipid nanoparticles (SLNs) containing Pentaclethra macroloba oleoresin, and the effects of therapeutic baths on the hematology (glucose, total proteins, and erythrocyte parameters) and gill histopathology of tambaqui Colossoma macropomum. The oleoresin used had a predominant composition of monounsaturated fatty acids in their composition, with oleic acid present at a relative abundance of 56.4% and behenic acid present at 15.8%. Tolerance trials with different concentrations of SLNs (500, 750, 1,000, and 2,000 mg\/L) showed that the fish could tolerate 500 mg\/L. This concentration was used for the five 1-h therapeutic baths per day. Two control groups were also used: one with water from the culture tank and the other with Tween 80 + myristic acid. The therapeutic baths' efficacy against dactylogyridean parasites was similar between the group with SLNs containing 500 mg\/L of P. macroloba oleoresin and the control group with Tween 80 + myristic acid. The therapeutic baths only increased plasma total protein levels. Histopathological analyses of tambaqui gills showed moderate changes that did not affect respiratory function in fish subjected to baths with SLNs containing P. macroloba oleoresin. Although the fish could tolerate 500 mg\/L of SLNs with P. macroloba oleoresin without experiencing adverse physiological effects, this treatment was therapeutically ineffective. The factors responsible for this ineffectiveness were discussed.<\/jats:p>","DOI":"10.1590\/1519-6984.300444","type":"journal-article","created":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T13:00:04Z","timestamp":1770382804000},"source":"Crossref","is-referenced-by-count":1,"title":["Anti-dactylogyridean efficacy of solid lipid nanoparticles of Pentaclethra macroloba oleoresin in Colossoma macropomum, with hematology and gill histopathology assessment"],"prefix":"10.1590","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8744-8753","authenticated-orcid":false,"given":"D. F.","family":"Malheiros","sequence":"first","affiliation":[{"name":"Universidade Federal do Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2039-2432","authenticated-orcid":false,"given":"M. F.","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5093-1300","authenticated-orcid":false,"given":"V. H. S.","family":"Marinho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0105","authenticated-orcid":false,"given":"I. M.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0167-6355","authenticated-orcid":false,"given":"E. T. O.","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amap\u00e1,  Brasil; Embrapa Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-2527","authenticated-orcid":false,"given":"H. C. R.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-6125","authenticated-orcid":false,"given":"K. M.","family":"Canuto","sequence":"additional","affiliation":[{"name":"Embrapa Agroind\u00fastria Tropical,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8376-1846","authenticated-orcid":false,"given":"M.","family":"Tavares-Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amap\u00e1,  Brasil; Embrapa Amap\u00e1,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s10499-025-01952-7","article-title":"Nanoparticle\u2011driven aquaculture: transforming disease management and boosting sustainable fish farming practices","volume":"33","author":"ABDELKARIM E.A.","year":"2025","journal-title":"Aquaculture International"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.1007\/s12010-023-04418-9","article-title":"Nanoencapsulated aquafeeds and current uses in fisheries\/shrimps: a review","volume":"195","author":"AHMED J.","year":"2023","journal-title":"Applied Biochemistry and Biotechnology"},{"issue":"1","key":"ref3","article-title":"Essential oil of Piper hispidum (Piperaceae) has efficacy against monogeneans, and effects on hematology and gill histology of Colossoma macropomum","volume":"33","author":"ALVES C.M.G.","year":"2024","journal-title":"Revista Brasileira de Parasitologia Veterin\u00e1ria = Brazilian Journal of Veterinary Parasitology: \u00d3rg\u00e3o Oficial do Col\u00e9gio Brasileiro de Parasitologia Veterin\u00e1ria"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10454438.2024.2419843","article-title":"Cichlidogyrosis in tropical aquaculture: pathological effects and infection dynamics in Nile tilapia Oreochromis niloticus, a case study in Campeche, Mexico","volume":"37","author":"\u00c1VILA-CASTILLO R.","year":"2024","journal-title":"Journal of Applied Aquaculture"},{"key":"ref5","series-title":"Manual de t\u00e9cnicas para histologia normal e patol\u00f3gica.","author":"BEHMER O.A.","year":"1976","edition":"1."},{"issue":"19","key":"ref6","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1016\/j.cub.2023.08.064","article-title":"The evolution of endoparasitism and complex life cycles in parasitic platyhelminths","volume":"33","author":"BRABEC J.","year":"2023","journal-title":"Current Biology: CB"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.2307\/3284227","article-title":"Parasitology meets ecology on its own terms: Margolis et al. revisited","volume":"83","author":"BUSH A.O.","year":"1997","journal-title":"The Journal of Parasitology"},{"issue":"1","key":"ref8","article-title":"Evaluation of bromocriptine and plumbagin against the monogenean Rhabdosynochus viridisi: computational drug repositioning and in vitro approaches","volume":"261","author":"CA\u00d1A-BOZADA V.H.","year":"2024","journal-title":"Experimental Parasitology"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1007\/s10973-012-2896-z","article-title":"Characterization of Pentaclethra macroloba oil","volume":"115","author":"COSTA M.N.F.S.","year":"2014","journal-title":"Journal of Thermal Analysis and Calorimetry"},{"key":"ref10","article-title":"Natural history of the hyperdominant tree, Pentaclethra macroloba (Willd.) 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