{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:03:33Z","timestamp":1764687813440},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Resumo Contexto A les\u00e3o no p\u00e9 de pacientes com diabetes \u00e9 um importante problema de sa\u00fade p\u00fablica que frequentemente est\u00e1 associado a amputa\u00e7\u00f5es em membros inferiores e mortalidade nessa popula\u00e7\u00e3o. Objetivos Investigar os fatores de risco associados a mortalidade em pacientes com p\u00e9 diab\u00e9tico infectado submetidos a amputa\u00e7\u00e3o maior. M\u00e9todos Estudo observacional, retrospectivo e caso-controle. Amostra composta por 78 pacientes com p\u00e9 diab\u00e9tico e \u00falcera infectada submetidos a amputa\u00e7\u00e3o maior em um servi\u00e7o de cirurgia vascular em um hospital universit\u00e1rio no per\u00edodo de 5 anos. Resultados A m\u00e9dia de idade da amostra estudada foi de 63,8 \u00b1 10,5 anos, com 54 (69,2%) pacientes do sexo masculino, com creatinina s\u00e9rica m\u00e9dia de 2,49 \u00b1 2,4 mg\/dL e hemoglobina s\u00e9rica m\u00e9dia de 7,36 \u00b1 1,7 g\/dL. Houve 47,4% de reinterna\u00e7\u00e3o. Foi realizada amputa\u00e7\u00e3o transtibial em 59,0% e transfemoral em 39,7% da amostra estudada. Nesta amostra, 87,2% dos pacientes apresentaram cultura positiva, predominantemente monomicrobiana (67,9%), e 30,8% apresentaram infec\u00e7\u00e3o hospitalar da \u00falcera. Os g\u00eaneros de bact\u00e9rias mais frequentes foram Acinetobacter spp. (24,4%), Morganella spp. (24,4%) e Proteus spp. (23,1%). Nenhum g\u00eanero bacteriano foi identificado como fator de risco para \u00f3bito. O n\u00edvel de creatinina \u2265 1,3 mg\/dL (OR 17,8; IC 2,1-150) e a amputa\u00e7\u00e3o transfemoral (OR 4,5; IC: 1,3-15,7) foram fatores de risco para o \u00f3bito. Conclus\u00f5es Os n\u00edveis s\u00e9ricos de creatinina \u2265 1,3 mg\/dL e amputa\u00e7\u00e3o transfemoral foram fatores de risco para \u00f3bito.<\/jats:p>","DOI":"10.1590\/1677-5449.010717","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:15:13Z","timestamp":1543943713000},"page":"296-302","source":"Crossref","is-referenced-by-count":15,"title":["Fatores de risco para mortalidade em pacientes submetidos a amputa\u00e7\u00f5es maiores por p\u00e9 diab\u00e9tico infectado"],"prefix":"10.1590","volume":"17","author":[{"given":"Nat\u00e1lia An\u00edcio","family":"Cardoso","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia de Loiola","family":"Cisneros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Jorge","family":"Machado","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Jayme","family":"Proc\u00f3pio","sequence":"additional","affiliation":[{"name":"Hospital Risoleta Tolentino Neves, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00falio Pinho","family":"Navarro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,12]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jdiacomp.2014.04.011","article-title":"The independent contribution of diabetic foot ulcer on lower extremity amputation and mortality risk","volume":"28","author":"Martins-Mendes D","year":"2014","journal-title":"J Diab 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