{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T22:52:15Z","timestamp":1772232735885,"version":"3.50.1"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Resumo A bullosis diabeticorum (BD) \u00e9 uma manifesta\u00e7\u00e3o cut\u00e2nea infrequente do diabetes e pode afetar os membros superiores. Caracteriza-se pelo aparecimento espont\u00e2neo e indolor de flictenas n\u00e3o inflamat\u00f3rias de aspecto sanguinolento, que podem evoluir para necrose, requerendo que se fa\u00e7a diagn\u00f3stico diferencial com doen\u00e7as dermatol\u00f3gicas, como porfiria cut\u00e2nea tarda, pseudoporfiria, epiderm\u00f3lise bolhosa adquirida e penfigoide bolhoso, e doen\u00e7as vasculares, como vasculites, doen\u00e7a arterial perif\u00e9rica, doen\u00e7a de Buerger, entre outras. Neste relato, descreve-se o caso de um paciente masculino de 77 anos, hipertenso e diab\u00e9tico mal controlado, apresentando aparecimento espont\u00e2neo de les\u00f5es bolhosas de membros superiores, que evolu\u00edram, ap\u00f3s ruptura espont\u00e2nea, para ulcerosas necr\u00f3ticas. A bi\u00f3psia da les\u00e3o diagnosticou a presen\u00e7a de espessamento hialino de vasos d\u00e9rmicos e de bolhas subc\u00f3rneas, compat\u00edveis com o diagn\u00f3stico de BD. Ap\u00f3s a interrup\u00e7\u00e3o do tabagismo e a otimiza\u00e7\u00e3o do controle glic\u00eamico associado a corticoterapia t\u00f3pica, houve melhora, com cicatriza\u00e7\u00e3o das les\u00f5es. A apresenta\u00e7\u00e3o da BD em membros superiores \u00e9 mais rara, sendo necess\u00e1rio o diagn\u00f3stico diferencial com outras les\u00f5es cut\u00e2neas e vasculares.<\/jats:p>","DOI":"10.1590\/1677-5449.202101901","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T21:26:39Z","timestamp":1671139599000},"source":"Crossref","is-referenced-by-count":1,"title":["Bullosis diabeticorum como diagn\u00f3stico diferencial de \u00falcera de membros: relato de caso"],"prefix":"10.1590","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9091-0224","authenticated-orcid":false,"given":"Vinicius Tadeu Ramos da Silva","family":"Grillo","sequence":"first","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra Souza","family":"Botelho","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9576-5625","authenticated-orcid":false,"given":"Eloana Pasqualin","family":"Lange","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1726-7732","authenticated-orcid":false,"given":"Murilo Sgarbi","family":"Secanho","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2622-286X","authenticated-orcid":false,"given":"Paula Angeleli Bueno de","family":"Camargo","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2596-9294","authenticated-orcid":false,"given":"H\u00e9lio Amante","family":"Miot","sequence":"additional","affiliation":[{"name":"Universidade Estadual Paulista J\u00falio de Mesquita Filho,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref1","series-title":"Diabetes complications, comorbidities and related disorders.","first-page":"1","volume-title":"Diabetes and the Skin.","author":"Gisondi P","year":"2018"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s40257-017-0275-z","article-title":"Cutaneous manifestations of diabetes mellitus: a review","volume":"18","author":"Lima AL","year":"2017","journal-title":"Am J Clin Dermatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.12659\/AJCR.905452","article-title":"Bullosis diabeticorum: a rare presentation with Immunoglobulin G (IgG) deposition related vasculopathy. 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