{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:05:56Z","timestamp":1753887956858,"version":"3.41.2"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract  Background Determination of predictors that can affect development of atherosclerosis progression in the postoperative period is an urgent problem in vascular surgery.  Objectives Integrated assessment of markers of apoptosis and cell proliferation in atherosclerotic lesions and their progression after surgery in patients with peripheral arterial diseases.  Methods The investigation included 30 patients with stage IIB-III peripheral arterial disease. All patients have undergone open surgical interventions on the arteries of the aorto-iliac and femoral-popliteal segments. During these interventions, intraoperative specimens were obtained from the vascular wall with atherosclerotic lesions. The following values were evaluated: VEGF \u0410165, PDGF BB, and sFas. Samples of normal vascular wall were obtained from post-mortem donors and used as a control group.  Results The levels of Bax and p53 were increased (p&lt;0.001) in samples from arterial wall with atherosclerotic plaque, while sFas values were reduced (p&lt;0.001), compared to their levels in control samples. Values of PDGF BB and VEGF A165 were 1.9 and 1.7 times higher in atherosclerotic lesion samples (p=0.001), in comparison with the control group. The levels of p53 and Bax were increased against a background of reduced sFas levels in samples with progression of atherosclerosis compared to their baseline values in samples with atherosclerotic plaque (p&lt;0.05).  Conclusions Initially increased values of the Bax marker against a background of reduced sFas values in vascular wall samples from patients with peripheral arterial disease is associated with risk of atherosclerosis progression in the postoperative period.<\/jats:p>","DOI":"10.1590\/1677-5449.202200292","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T13:54:55Z","timestamp":1676037295000},"source":"Crossref","is-referenced-by-count":0,"title":["Comprehensive assessment of markers of apoptosis and cell proliferation during progression of atherosclerosis after surgery in patients with peripheral arterial disease"],"prefix":"10.1590","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0817-9573","authenticated-orcid":false,"given":"Roman Evgenyevich","family":"Kalinin","sequence":"first","affiliation":[{"name":"Ryazan State Medical University,  Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1292-5452","authenticated-orcid":false,"given":"Igor Aleksandrovich","family":"Suchkov","sequence":"additional","affiliation":[{"name":"Ryazan State Medical University,  Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4855-9068","authenticated-orcid":false,"given":"Emma Anatolievna","family":"Klimentova","sequence":"additional","affiliation":[{"name":"Ryazan State Medical University,  Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","article-title":"Primary stenting for femoropopliteal peripheral arterial disease: analysis up to 24 months","volume":"18","author":"Geiger MA","year":"2019","journal-title":"J Vasc Bras"},{"issue":"6S","key":"ref2","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/j.jvs.2019.02.016","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"69","author":"Conte MS","year":"2019","journal-title":"J Vasc Surg"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.jvs.2017.01.025","article-title":"Outcomes of open and endovascular lower extremity revascularization in active smokers with advanced peripheral arterial disease","volume":"65","author":"Chen SL","year":"2017","journal-title":"J Vasc Surg"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jacbts.2020.01.013","article-title":"Perking up strategies to control restenosis","volume":"5","author":"Riascos-Bernal DF","year":"2020","journal-title":"JACC Basic Transl Sci"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00018-018-2983-9","article-title":"Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis","volume":"76","author":"Paone S","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.17816\/KMJ2021-855","article-title":"Influence of the geometry of the proximal anastomosis, markers of apoptosis and cell proliferation on the long-term results of patency after reconstructive interventions on the arteries of the femoropopliteal segment","volume":"102","author":"Kalinin RE","year":"2021","journal-title":"Kazan Med J."},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"669","DOI":"10.23934\/2223-9022-2021-10-4-669-675","article-title":"Markers of development of restenosis of the reconstruction zone after endovascular interventions on the arteries of the lower limbs","volume":"10","author":"Kalinin RE","year":"2021","journal-title":"Russian Sklifosovsky J Emergency Med Care."},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.mehy.2006.07.037","article-title":"In atherogenesis, the apoptosis of endothelial cell itself could directly induce over-proliferation of smooth muscle cells","volume":"68","author":"Qin C","year":"2007","journal-title":"Med Hypotheses"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.23888\/PAVLOVJ202028179-87","article-title":"Apoptosis in vascular pathology: present and future. I.P","volume":"28","author":"Kalinin RE","year":"2020","journal-title":"Pavlov Russian Med Biol Herald."},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"332","DOI":"10.23736\/S0026-4725.20.04995-6","article-title":"The circulating vascular endothelial growth factor is only marginally associated with an increased risk for atherosclerosis","volume":"68","author":"Pauli N","year":"2020","journal-title":"Minerva Cardioangiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2017.03.003","article-title":"PDGFs and their receptors","volume":"614","author":"Kazlauskas A","year":"2017","journal-title":"Gene"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1590\/S1677-54492011000400001","article-title":"Tamanho da amostra em estudos cl\u00ednicos e experimentais","volume":"10","author":"Miot HA","year":"2011","journal-title":"J Vasc Bras"},{"issue":"6","key":"ref13","first-page":"10","article-title":"Methods for determining the minimum required sample size in medical research","volume":"65","author":"Narkevich AN","year":"2019","journal-title":"Social Aspects Popul Health."},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.18632\/aging.103034","article-title":"Downregulation of LncRNA NORAD promotes Ox-LDL-induced vascular endothelial cell injury and atherosclerosis","volume":"12","author":"Bian W","year":"2020","journal-title":"Aging"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.3390\/biom10111558","article-title":"Oxidative stress and mitochondrial dysfunction in human diseases: pathophysiology, predictive biomarkers, therapeutic","volume":"10","author":"Li CJ","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/MOL.0000000000000394","article-title":"The walking dead: macrophage inflammation and death in atherosclerosis","volume":"28","author":"Kavurma MM","year":"2017","journal-title":"Curr Opin Lipidol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.cjca.2016.12.010","article-title":"Macrophage apoptosis and necrotic core development in atherosclerosis: a rapidly advancing field with clinical relevance to imaging and therapy","volume":"33","author":"Gonzalez L","year":"2017","journal-title":"Can J Cardiol"}],"container-title":["Jornal Vascular Brasileiro"],"original-title":["Avalia\u00e7\u00e3o integral de marcadores de apoptose e prolifera\u00e7\u00e3o celular na progress\u00e3o da aterosclerose ap\u00f3s cirurgia em pacientes com doen\u00e7a arterial perif\u00e9rica"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1677-54492023000100302&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T13:55:11Z","timestamp":1676037311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1677-54492023000100302&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":17,"alternative-id":["S1677-54492023000100302"],"URL":"https:\/\/doi.org\/10.1590\/1677-5449.202200292","relation":{},"ISSN":["1677-7301","1677-5449"],"issn-type":[{"type":"electronic","value":"1677-7301"},{"type":"print","value":"1677-5449"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e20220029"}}