{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:06:32Z","timestamp":1776722792219,"version":"3.51.2"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract Iron overload, whether acute or chronic, has been implicated in the pathogenesis of ischemic cardiovascular diseases. However, its effects on peripheral vascular function and thrombotic responses to endothelial injury remain incompletely elucidated. We present a case of inadvertent intra-arterial infusion of ferric hydroxide saccharate (Noripurum\u00ae), resulting in severe acute arterial occlusion, most likely secondary to diffuse endothelial injury. Despite prompt surgical intervention and adjunctive pharmacological therapy, the clinical outcome was unfavorable. Given the lack of similar reports in major scientific databases and the involvement of complex, yet poorly characterized, interactions between iron overload and endothelial dysfunction, this case contributes valuable insights into the vascular implications of parenteral iron administration.<\/jats:p>","DOI":"10.1590\/1677-5449.202500552","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:05:10Z","timestamp":1774263910000},"source":"Crossref","is-referenced-by-count":1,"title":["Acute arterial occlusion following inadvertent infusion of ferric hydroxide sacarate (Noripurum\u00ae) into the radial artery: case report"],"prefix":"10.1590","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4034-0523","authenticated-orcid":false,"given":"Daniel C\u00e9sar Magalh\u00e3es","family":"Fernandes","sequence":"first","affiliation":[{"name":"Hospital Geral de Goi\u00e2nia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3350-9610","authenticated-orcid":false,"given":"Daniel Rassi","family":"Gusmao","sequence":"additional","affiliation":[{"name":"Instituto de Angiologia de Goi\u00e2nia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9654-9876","authenticated-orcid":false,"given":"Felipe Mendon\u00e7a Oliveira e","family":"Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3464-919X","authenticated-orcid":false,"given":"Juliano Ricardo Santana dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s,  Brasil; Einstein, Hospital Municipal de Aparecida,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5374-6306","authenticated-orcid":false,"given":"Beatriz Franco","family":"Fidalgo","sequence":"additional","affiliation":[{"name":"Hospital Geral de Goi\u00e2nia,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/1358836X9900400207","article-title":"Iron-mediated cardiovascular injury","volume":"4","author":"Horwitz LD","year":"1999","journal-title":"Vasc Med"},{"key":"ref2","series-title":"Wintrobe\u2019s clinical hematology.","first-page":"872","volume-title":"Hemochromatosis and other iron storages disorders.","author":"Edwards CQ","year":"1993"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1161\/01.CIR.86.3.803","article-title":"High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men","volume":"86","author":"Salonen JT","year":"1992","journal-title":"Circulation"},{"issue":"24","key":"ref4","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1161\/01.CIR.99.24.3118","article-title":"Iron-dependent human platelet activation and hydroxyl radical formation: involvement of protein kinase C","volume":"99","author":"Pratic\u00f2 D","year":"1999","journal-title":"Circulation"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1182\/blood.V96.9.3056","article-title":"Smooth muscle cell surface tissue factor pathway activation by oxidized low-density lipoprotein requires cellular lipid peroxidation","volume":"96","author":"Penn MS","year":"2000","journal-title":"Blood"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S1537-1891(02)00250-1","article-title":"Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis","volume":"38","author":"Russo G","year":"2002","journal-title":"Vascul Pharmacol"},{"issue":"20","key":"ref7","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1161\/01.CIR.0000066910.02844.D0","article-title":"Chronic iron administration increases vascular oxidative stress and accelerates arterial thrombosis","volume":"107","author":"Day SM","year":"2003","journal-title":"Circulation"},{"key":"ref8","series-title":"Iron and oxygen: a dangerous mixture.","author":"Gutteridge JMCHB","year":"1990"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"67B","DOI":"10.1016\/0002-9149(95)80016-L","article-title":"Vascular endothelium: an integrator of pathophysiologic stimuli in atherosclerosis","volume":"75","author":"Gimbrone Jr MA","year":"1995","journal-title":"Am J Cardiol"},{"issue":"27","key":"ref10","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1056\/NEJM199312303292706","article-title":"The L-arginine-nitric oxide pathway","volume":"329","author":"Epstein FH","year":"1993","journal-title":"N Engl J Med"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","DOI":"10.1002\/hem3.140","article-title":"Improving CORM technology for the treatment of delayed hemolytic transfusion reaction","volume":"8","author":"Asperti M","year":"2024","journal-title":"HemaSphere"},{"key":"ref12","first-page":"109","article-title":"Isquemia de membro superior ap\u00f3s inje\u00e7\u00e3o intramuscular de ampicilina benzatina e dipirona magn\u00e9sica: relato de um caso","volume":"15","author":"Yoshida WB","year":"1999","journal-title":"Cir Vasc Angiol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1590\/S1677-54492009000300009","article-title":"Acidente por inje\u00e7\u00e3o medicamentosa no m\u00fasculo deltoide: les\u00f5es locais e \u00e0 dist\u00e2ncia, revis\u00e3o de 32 casos","volume":"8","author":"Duque FLV","year":"2009","journal-title":"J Vasc Bras"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12882-022-02896-3","article-title":"The effect of intravenous iron supplementation on exercise capacity in iron-deficient but not anaemic patients with chronic kidney disease: study design and baseline data for a multicentre prospective double-blind randomised controlled trial","volume":"23","author":"Greenwood SA","year":"2022","journal-title":"BMC Nephrol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1046\/j.1365-2362.2002.0320s1009.x","article-title":"Ferric saccharate induces oxygen radical stress and endothelial dysfunction in vivo","volume":"32","author":"Rooyakkers TM","year":"2002","journal-title":"Eur J Clin Invest"}],"container-title":["Jornal Vascular Brasileiro"],"original-title":["Oclus\u00e3o arterial aguda ap\u00f3s infus\u00e3o inadvertida de sacarato de hidr\u00f3xido f\u00e9rrico (Noripurum\u00ae) na art\u00e9ria radial: relato de caso"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S1677-54492026000101802&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:05:14Z","timestamp":1774263914000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1677-54492026000101802&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":15,"alternative-id":["S1677-54492026000101802"],"URL":"https:\/\/doi.org\/10.1590\/1677-5449.202500552","relation":{"has-translation":[{"id-type":"doi","id":"10.1590\/1677-5449.202500551","asserted-by":"subject"}]},"ISSN":["1677-7301","1677-5449"],"issn-type":[{"value":"1677-7301","type":"electronic"},{"value":"1677-5449","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e20250055"}}