{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:10:09Z","timestamp":1788901809648,"version":"build-2803163510"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Valley Research Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract  Background Primary hyperhidrosis is a chronic condition with limited therapeutic options.  Objectives To evaluate the impact of 10% oxybutynin spray on axillary hyperhidrosis, considering both its local and systemic effects, in terms of Hyperhidrosis Disease Severity Scale (HDSS) outcomes for hyperhidrosis of the axilla and eight additional sites.  Methods Prospective phase II PROBE design trial. Adult patients with axillary hyperhidrosis were randomized to receive a 10% oxybutynin topical spray, oral oxybutynin, or placebo spray for 35 days. Efficacy was evaluated on day 35 using the HDSS and a hyperhidrosis-specific quality-of-life (QoL) assessment questionnaire.  Results 17 patients were randomized. No significant differences were observed in HDSS outcomes from baseline to day 35 in any of the three groups (2.5 [2 - 4], 4 [3 - 4], 3.5 [3 - 4], p= 0.207), although a trend to improvement was noted in both treatment groups. Significant improvement in the QoL questionnaire was observed from baseline to day 35 in the oxybutynin spray group (pre-intervention QoL: 78.5 [70 - 96] and post-intervention QoL: 38.5 [32 - 67], p = 0.031).  Conclusions No differences were observed in the primary outcome. A significant improvement from baseline to day 35 was observed in the QoL questionnaire score for the oxybutynin spray group.<\/jats:p>","DOI":"10.1590\/1677-5449.20250065","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:30:26Z","timestamp":1788899426000},"source":"Crossref","is-referenced-by-count":0,"title":["Topical oxybutynin antiperspirant for axillary hyperhidrosis: a phase IIb PROBE design clinical trial (TODAY trial)"],"prefix":"10.1590","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-9092","authenticated-orcid":false,"given":"Samantha","family":"Neves","sequence":"first","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-2887","authenticated-orcid":false,"given":"Elisete Isabel","family":"Crocco","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0520-0503","authenticated-orcid":false,"given":"Viviane Santana da","family":"Silva","sequence":"additional","affiliation":[{"name":"Science Valley Research Institute,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6978-2798","authenticated-orcid":false,"given":"Felipe","family":"Menegueti","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-1821","authenticated-orcid":false,"given":"Alexia","family":"Paganotti","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6008-589X","authenticated-orcid":false,"given":"Ricardo Sanchez","family":"Boix","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina do ABC,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1991-3507","authenticated-orcid":false,"given":"Nelson","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6352-4408","authenticated-orcid":false,"given":"Roberto Augusto","family":"Caffaro","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil; Hospital Alem\u00e3o Oswaldo Cruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jaad.2018.12.071","article-title":"The etiology, diagnosis, and management of hyperhidrosis: a comprehensive review. 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Marked reduction of social phobia, anxiety, and depression and increased quality of life after treatment with botulinum toxin A","volume":"152","author":"Weber A","year":"2005","journal-title":"Br J Dermatol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.det.2014.06.013","article-title":"Botulinum toxin for axillary hyperhidrosis","volume":"32","author":"de Almeida AR","year":"2014","journal-title":"Dermatol Clin"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.avsg.2011.06.007","article-title":"The use of oxybutynin for treating axillary hyperhidrosis","volume":"25","author":"Wolosker N","year":"2011","journal-title":"Ann Vasc Surg"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.avsg.2013.12.024","article-title":"Long-term results of the use of oxybutynin for the treatment of axillary hyperhidrosis","volume":"28","author":"Wolosker 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Trials","volume":"20","author":"Pariser DM","year":"2019","journal-title":"Am J Clin Dermatol"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jaad.2023.03.025","article-title":"A novel lotion formulation of 20% oxybutynin hydrochloride for the treatment of primary palmar hyperhidrosis: a randomized, placebo-controlled, double-blind, phase III study","volume":"89","author":"Fujimoto T","year":"2023","journal-title":"J Am Acad Dermatol"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1111\/jocd.15715","article-title":"Oxybutynin gel versus nanoemulgel for treating primary palmar hyperhidrosis: a pilot double-blind randomized controlled trial","volume":"22","author":"Saki N","year":"2023","journal-title":"J Cosmet Dermatol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1111\/pde.13404","article-title":"Oxybutynin 3% gel for the treatment of primary focal 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