{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:10:09Z","timestamp":1788901809508,"version":"build-2803163510"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract  Context Chronic extremity ulcers represent a major clinical challenge. Adipose-derived stem cells (ADSCs) have emerged as a promising therapeutic option for wound healing; however, their efficacy and safety remain incompletely established.  Objectives To evaluate the efficacy and safety of ADSCs compared with conventional treatment.  Methods A systematic review and meta-analysis of 11 randomized clinical trials involving 474 patients was conducted. Outcomes included healing rate, mean healing time, pain-related outcomes, and safety. Odds ratios (ORs) and weighted mean differences were used as summary effect measures.  Results Complete healing rates were significantly higher in the ADSC group than in the conventional treatment group (84.2% vs. 49.0%; OR 5.77; p &lt; 0.00001). Healing time was reduced by 19.39 days on average in ADSC group (p = 0.0004). No statistically significant differences were observed regarding pain outcomes or complication rates (p = 0.22).  Conclusion ADSC therapy increased healing rates and shortened healing time in patients with chronic extremity ulcers, with no evidence of a significant increase in treatment-related risks. However, the heterogeneity of the findings and the limited sample size highlight the need for studies with greater statistical power and methodological standardization to confirm these results.<\/jats:p>","DOI":"10.1590\/1677-5449.202501392","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:30:53Z","timestamp":1788899453000},"source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and safety of adipose tissue-derived cell therapy in the treatment of chronic extremity ulcers: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1590","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8372-0201","authenticated-orcid":false,"given":"Edenilson de Souza","family":"Teixeira","sequence":"first","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3776-3118","authenticated-orcid":false,"given":"Vanessa Ellen Silva","family":"Carmo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3999-705X","authenticated-orcid":false,"given":"Hideki Zimermann","family":"Kamitani","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-5287","authenticated-orcid":false,"given":"Johnnatas Mikael","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil; Universidade Federal do Rio Grande do Norte,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1538-2358","authenticated-orcid":false,"given":"Sydney Correia","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil; Universidade de Ci\u00eancias da Sa\u00fade de Porto Alegre,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0637-2070","authenticated-orcid":false,"given":"Carlos Alberto de Lima","family":"Botelho Filho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil; Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1032-6015","authenticated-orcid":false,"given":"Pedro Pereira","family":"Ten\u00f3rio","sequence":"additional","affiliation":[{"name":"Universidade Federal do Vale do S\u00e3o Francisco,  Brasil; Universidade Federal de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13643-016-0400-8","article-title":"The humanistic and economic burden of chronic wounds: a protocol for a systematic review","volume":"6","author":"J\u00e4rbrink K","year":"2017","journal-title":"Syst Rev"},{"key":"ref2","article-title":"Bacterial cellulose biomaterials for the treatment of lower limb ulcers","volume":"50","author":"Oliveira GMD","year":"2023","journal-title":"Rev Col Bras Cir"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1590\/1980-265x-tce-2022-0010en","article-title":"Health-related quality of life in people with chronic wounds and associated factors","volume":"31","author":"Dantas JS","year":"2022","journal-title":"Texto Contexto Enferm"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000381877","article-title":"Stem cells in wound healing: the future of regenerative medicine? 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