{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:06:45Z","timestamp":1790593605202,"version":"4.1.0"},"reference-count":46,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract  Background Numerous studies have shown a link between the angiotensin-converting enzyme (ACE) and ischemic stroke. Cryptogenic ischemic stroke is the most commonly recorded form of ischemic stroke among young adults. The insertion\/deletion (I\/D) variant of ACE (rs4646994) has been linked to ischemic stroke.  Objectives We examined the potential correlation between this single nucleotide polymorphism and cryptogenic ischemic stroke in young adults.  Methods This case-control study included 42 young adults (&lt; 50 years of age) diagnosed with cryptogenic ischemic stroke according to the TOAST classification, along with 42 healthy controls from the general population. The vascular risk factors included hypertension, diabetes mellitus, dyslipidemia, smoking, and cardiovascular diseases. Genomic deoxyribonucleic acid was extracted, and the ACE rs4646994 polymorphism was examined using polymerase chain reaction.  Results Younger age (p = 0.004) and female sex (p = 0.007) were significantly connected to an increased risk of stroke, contrasting with typical stroke demographics. Hypertension (p = 0.002) and smoking (p = 0.04) emerged as important, modifiable risk factors. There was no notable distinction between patients and controls regarding the frequencies of alleles and genotypes of the ACE I\/D single nucleotide polymorphism (p &gt; 0.05). These results were not associated with cryptogenic ischemic stroke.  Conclusions While aligning with the current literature, our results are constrained by the limited sample size, the case-control design, and the dependence on self-reported data, which could have led to bias. This genetic study of a population from eastern Algeria did not show a link between the ACEI\/D single nucleotide polymorphism and cryptogenic ischemic stroke.<\/jats:p>","DOI":"10.1590\/1677-5449.202501422","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T10:52:59Z","timestamp":1790592779000},"source":"Crossref","is-referenced-by-count":0,"title":["Case-control study on the association of angiotensin-converting enzyme gene I\/D rs4646944 single nucleotide polymorphism and young-onset cryptogenic ischemic stroke in an Algerian cohort"],"prefix":"10.1590","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7097-224X","authenticated-orcid":false,"given":"Mohamed","family":"Lebsir","sequence":"first","affiliation":[{"name":"University of Constantine 1 Mentouri","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-7039","authenticated-orcid":false,"given":"Mohamed Larbi","family":"Rezgoun","sequence":"additional","affiliation":[{"name":"University of Constantine 1 Mentouri","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0772-9892","authenticated-orcid":false,"given":"Boubekeur Saddik","family":"Fekraoui","sequence":"additional","affiliation":[{"name":"University of Constantine 3, Salah Boubnider","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7924-2939","authenticated-orcid":false,"given":"Brahim","family":"Djoudi","sequence":"additional","affiliation":[{"name":"University of Constantine 1 Mentouri","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5159-5921","authenticated-orcid":false,"given":"Yasmina","family":"Boukhenaf","sequence":"additional","affiliation":[{"name":"University of Constantine 1 Mentouri","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6290-3058","authenticated-orcid":false,"given":"Amina Ines","family":"Bernou","sequence":"additional","affiliation":[{"name":"University of Constantine 1 Mentouri","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7132-5150","authenticated-orcid":false,"given":"Karima","family":"Sifi","sequence":"additional","affiliation":[{"name":"University of Constantine 3, Salah Boubnider","place":["Constantine, Algeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"l6983","DOI":"10.1136\/bmj.l6983","article-title":"Management of acute ischemic stroke.","volume":"368","author":"Phipps MS","year":"2020","journal-title":"BMJ"},{"issue":"7","key":"ref2","first-page":"2160","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"Kernan WN","year":"2014","journal-title":"S troke"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105046","article-title":"Young cryptogenic ischemic stroke: a descriptive analysis of clinical and laboratory characteristics, outcomes and stroke recurrence.","volume":"29","author":"Divi\u0161ov\u00e1 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