{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:20Z","timestamp":1792788680648,"version":"4.5.0"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"FAPERGS","award":["24\/2551-000748-2"],"award-info":[{"award-number":["24\/2551-000748-2"]}],"id":[{"id":"https:\/\/ror.org\/05k49za97","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. vasc. bras."],"abstract":"<jats:p>Abstract Lipedema is a chronic adipose tissue disorder that predominantly affects women, although some rare cases do occur in men. We report the case of a 32-year-old man with symmetrical, lower-limb fat accumulation, foot sparing, pain, easy bruising, and a positive family history of lipedema. His first-degree female cousin exhibited the classic phenotype. Dual-energy X-ray absorptiometry demonstrated greater fat accumulation in the gynoid than in the android and visceral regions, reinforcing a predominantly gluteofemoral adiposity pattern. The patient underwent a 7-month personalized nutritional intervention consisting of a moderately hypocaloric, high-protein, low-glycemic diet with vitamin D supplementation and regular physical activity. This intervention was associated with reductions in anthropometric measurements and decreased pain scores on a Visual Analogue Scale. Laboratory tests revealed a preserved hypothalamic\u2013pituitary\u2013gonadal axis, except for mild idiopathic hyperprolactinemia that normalized during follow-up. This case highlights lipedema in men and the potential benefits of early lifestyle-based interventions.<\/jats:p>","DOI":"10.1590\/1677-5449.202502102","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T10:50:42Z","timestamp":1791543042000},"source":"Crossref","is-referenced-by-count":0,"title":["Lipedema in a male patient: familial evidence and clinical response to nutritional intervention \u2013 case report"],"prefix":"10.1590","volume":"25","author":[{"given":"Michelle","family":"Kaefer","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Candia","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Fontana de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Eduarda de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ighor Seiji Okumura","family":"Tioda","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas","place":["Campinas, SP, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Buhse","family":"Pasqualoto","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00f3vis","family":"Paniz","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8601-5630","authenticated-orcid":false,"given":"Jos\u00e9 Antonio Mainardi de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria","place":["Santa Maria, RS, Brasil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"9","key":"ref1","article-title":"Lipedema: a relatively common disease with extremely common misconceptions","volume":"4","author":"Buck II DW","year":"2016","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/oby.23458","article-title":"Lymphatic function and anatomy in early stages of lipedema","volume":"30","author":"Rasmussen JC","year":"2022","journal-title":"Obesity (Silver 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