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Shaping ability in simulated curved canals","volume":"35","author":"Sch\u00e4fer E","year":"2002","journal-title":"Int Endod J"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/iej.12507","article-title":"Endodontic medicine: connections between apical periodontitis and systemic diseases","volume":"48","author":"Segura-Egea JJ","year":"2015","journal-title":"Int Endod J"},{"key":"ref90","series-title":"Endodontology: biologic considerations in endodontic procedures","first-page":"389","volume-title":"Repair following root canal therapy","author":"Seltzer S","year":"1988"},{"issue":"2","key":"ref91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4103\/0972-124X.44089","article-title":"Comparison of neutrophil functions in diabetic and healthy subjects with chronic generalized periodontitis","volume":"12","author":"Shetty N","year":"2008","journal-title":"J Indian Soc 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