{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:04Z","timestamp":1787023084013,"version":"build-2736575974"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Appl. Oral Sci."],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1590\/1679-775720130089","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T20:37:08Z","timestamp":1444768628000},"page":"235-242","source":"Crossref","is-referenced-by-count":24,"title":["Effect of MTA-based sealer on the healing of periapical lesions"],"prefix":"10.1590","volume":"21","author":[{"given":"Joao Eduardo","family":"GOMES-FILHO","sequence":"first","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"WATANABE","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano Tavares Angelo","family":"CINTRA","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Juvenal","family":"NERY","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloi","family":"DEZAN-JUNIOR","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"India Olinta Azevedo","family":"QUEIROZ","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Simonetti","family":"LODI","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Daniela","family":"BASSO","sequence":"additional","affiliation":[{"name":"UNESP  Univ. Estadual Paulista,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1046\/j.1365-2591.1999.00196.x","article-title":"Antimicrobial effects of various endodontic irrigants on selected microorganisms","volume":"32","author":"Ayhan H","year":"1999","journal-title":"Int Endod J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1590\/S0103-64402005000200012","article-title":"Comparative study of MTA and other materials in retrofilling of pulpless dogs' teeth","volume":"16","author":"Bernab\u00e9 PF","year":"2005","journal-title":"Braz Dent J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.joen.2011.11.003","article-title":"Cytotoxicity and genotoxicity of root canal sealers based on mineral trioxide aggregate","volume":"38","author":"Bin CV","year":"2012","journal-title":"J Endod"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2591.2011.01992.x","article-title":"Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test","volume":"45(5)","author":"Borges RP","year":"2012","journal-title":"Int Endod J"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00004770-200401000-00013","article-title":"<italic>In vitro<\/italic> antibacterial activities of root-canal sealers by using two different methods","volume":"30","author":"Cobankara FK","year":"2004","journal-title":"J Endod"},{"key":"ref6","first-page":"3","article-title":"Antimicrobial and chemical study of MTA, Portland cement, calcium hydroxide paste, Sealapex and Dycal","volume":"11","author":"Estrela C","year":"2000","journal-title":"Braz Dent J"},{"key":"ref7","first-page":"85","article-title":"Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria","volume":"6","author":"Estrela C","year":"1995","journal-title":"Braz Dent J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.tripleo.2008.03.030","article-title":"Reaction of rat connective tissue to a new calcium hydroxide-based sealer","volume":"106","author":"Gomes-Filho JE","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.joen.2008.11.006","article-title":"A mineral trioxide aggregate sealer stimulated mineralization","volume":"35","author":"Gomes-Filho JE","year":"2009","journal-title":"J Endod"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1600-9657.2011.01096.x","article-title":"Rat tissue reaction to MTA FILLAPEX\u00ae","volume":"28","author":"Gomes-Filho JE","year":"2012","journal-title":"Dent Traumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1590\/S1806-83242009000200005","article-title":"Radiopacity evaluation of root canal sealers containing calcium hydroxide and MTA","volume":"23","author":"Guerreiro-Tanomaru JM","year":"2009","journal-title":"Braz Oral Res"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00004770-200302000-00009","article-title":"A comparison of one versus two appointment endodontic therapy in dogs' teeth with apical periodontitis","volume":"29","author":"Holland R","year":"2003","journal-title":"J Endod"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0099-2399(85)80199-0","article-title":"Ability of a new calcium hydroxide root canal filling material to induce hard tissue formation","volume":"11","author":"Holland R","year":"1985","journal-title":"J Endod"},{"key":"ref14","first-page":"109","article-title":"Healing process of dog dental pulp after pulpotomy and pulp covering with mineral trioxide aggregate or Portland cement","volume":"12","author":"Holland R","year":"2001","journal-title":"Braz Dent J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0099-2399(99)80134-4","article-title":"Reaction of rat connective tissue to implanted dentin tubes filled with mineral trioxide aggregate or calcium hydroxide","volume":"25","author":"Holland R","year":"1999","journal-title":"J Endod"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/00004770-200111000-00011","article-title":"The effect of maintaining apical patency on periapical extrusion","volume":"27","author":"Lambrianidis T","year":"2001","journal-title":"J Endod"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1590\/S0103-64402009000100003","article-title":"L929 cell response to root perforation repair cements: an <italic>in vitro<\/italic> cytotoxicity assay","volume":"20","author":"Miranda RB","year":"2009","journal-title":"Braz Dent J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1365-2591.2011.01931.x","article-title":"Antibacterial activity of two MTA-based root canal sealers","volume":"44","author":"Morgental RD","year":"2011","journal-title":"Int Endod J"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tripleo.2004.10.005","article-title":"Microbial status of apical root canal system of human mandibular first molars with primary apical periodontitis after \u00e2\u20ac\u0153one-visit\u00e2\u20ac\ufffd endodontic treatment","volume":"99","author":"Nair PN","year":"2005","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2591.2005.00955.x","article-title":"Effectiveness of single-versus multiple-visit endodontic treatment of teeth with apical periodontitis: a systematic review and meta-analysis","volume":"38","author":"Sathorn C","year":"2005","journal-title":"Int Endod J"},{"key":"ref21","first-page":"326","article-title":"Multifaceted use of ProRoot MTA root canal repair material","volume":"23","author":"Schmitt D","year":"2001","journal-title":"Pediatr Dent"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/S0103-64402007000400005","article-title":"Periradicular repair after two-visit endodontic treatment using two different intracanal medications compared to single-visit endodontic treatment","volume":"18","author":"Silveira AM","year":"2007","journal-title":"Braz Dent J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00004770-200005000-00005","article-title":"Antimicrobial activity and flow rate of newer and established root canal sealers","volume":"26","author":"Siqueira JF","year":"2000","journal-title":"J Endod"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1365-2591.1997.tb00708.x","article-title":"Evaluation of the effectiveness of sodium hypochlorite used with three irrigation methods in the elimination of <italic>Enterococcus faecalis<\/italic> from the root canal, in vitro","volume":"30","author":"Siqueira JF","year":"1997","journal-title":"Int Endod J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00004770-200006000-00006","article-title":"Chemomechanical reduction of the bacterial population in the root canal after instrumentation and irrigation with 1%, 2.5%, and 5.25% sodium hypochlorite","volume":"26","author":"Siqueira JF","year":"2000","journal-title":"J Endod"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1365-2591.1997.tb00714.x","article-title":"Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis","volume":"30","author":"Sj\u00f6gren U","year":"1997","journal-title":"Int Endod J"},{"key":"ref27","first-page":"147","article-title":"Antimicrobial activity of endodontic sealers based on calcium hydroxide and MTA","volume":"21","author":"Tanomaru JM","year":"2008","journal-title":"Acta Odontol Latinoam"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0099-2399(06)80967-2","article-title":"Physical and chemical properties of a new root-end filling material","volume":"21","author":"Torabinejad M","year":"1995","journal-title":"J Endod"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0099-2399(06)81169-6","article-title":"Endodontic treatment of teeth with apical periodontitis: single vs. multivisit treatment","volume":"25","author":"Trope M","year":"1999","journal-title":"J Endod"}],"container-title":["Journal of Applied Oral Science"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jaos\/v21n3\/1678-7757-jaos-21-03-235.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T11:26:31Z","timestamp":1495884391000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1678-77572013000300235&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S1678-77572013000300235"],"URL":"https:\/\/doi.org\/10.1590\/1679-775720130089","relation":{},"ISSN":["1678-7757"],"issn-type":[{"value":"1678-7757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6]]}}}