{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:15Z","timestamp":1771550715661,"version":"3.50.1"},"reference-count":35,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Appl. Oral Sci."],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1590\/1679-775720130252","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T17:13:21Z","timestamp":1488993201000},"page":"430-436","source":"Crossref","is-referenced-by-count":11,"title":["Leukotoxicity of Aggregatibacter actinomycetemcomitans in generalized aggressive periodontitis in Brazilians and their family members"],"prefix":"10.1590","volume":"21","author":[{"given":"Virginia Regia Souza","family":"Silveira","sequence":"first","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia Viana Bessa","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia Accioly Pinto","family":"Nogueira","sequence":"additional","affiliation":[{"name":", Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilma","family":"Lima","sequence":"additional","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia Aparecida Chaves","family":"Furlaneto","sequence":"additional","affiliation":[{"name":"Univ. Estadual Paulista, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Otavio","family":"Rego","sequence":"additional","affiliation":[{"name":"Federal University of Ceara, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J","year":"1975","journal-title":"Int Dent J"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1399-302X.1996.tb00180.x","article-title":"Polymerase chain reaction detection of 8 putative periodontal pathogens in subgingival plaque of gingivitis and advanced periodontitis lesions","volume":"1","author":"Ashimoto A","year":"1996","journal-title":"Oral Microbiol Immunol"},{"key":"ref3","series-title":"S\u00edntese de indicadores sociais [online]","year":"2010"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1128\/IAI.62.2.501-508.1994","article-title":"Regulation of Actinobacillus actinomycetemcomitans leukotoxin expression: analysis of the promoter regions of leukotoxic and minimally leukotoxic strains","volume":"62","author":"Brogan JM","year":"1994","journal-title":"Infect Immun"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1902\/jop.1998.69.9.998","article-title":"Relationship between conversion of localized juvenile periodontitis-susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure","volume":"69","author":"Bueno LC","year":"1998","journal-title":"J Periodontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1600-051X.2009.01410.x","article-title":"Aggressive periodontitis is likely influenced by a few small effect genes","volume":"36","author":"Carvalho FM","year":"2009","journal-title":"J Clin Periodontol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1902\/jop.2009.090185","article-title":"Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray","volume":"80","author":"Colombo AP","year":"2009","journal-title":"J Periodontol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1034\/j.1399-302x.2000.150513.x","article-title":"Frequency of 530-bp deletion in Actinobacillus actinomycetemcomitans leukotoxin promoter region","volume":"15","author":"Contreras A","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1128\/JCM.00338-09","article-title":"Diminished treatment response of periodontally diseased patients infected with the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans","volume":"47","author":"Cortelli SC","year":"2009","journal-title":"J Clin Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1590\/S1517-74912003000200016","article-title":"Detection of highly and minimally leukotoxic Actinobacillus actinomycetemcomitans strains in patients with periodontal disease","volume":"17","author":"Cortelli SC","year":"2003","journal-title":"Pesqui Odontol Bras"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1902\/jop.2008.070270","article-title":"Consistent intrafamilial transmission of Actinobacillus actinomycetemcomitans despite clonal diversity","volume":"79","author":"Dogan B","year":"2008","journal-title":"J Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1600-0765.2010.01337.x","article-title":"Prevalence of Aggregatibacter actinomycetemcomitans in Sudanese patients with aggressive periodontitis: a case-control study","volume":"46","author":"Elamin A","year":"2011","journal-title":"J Periodontal Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0757.2006.00189.x","article-title":"How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases","volume":"42","author":"Fine DH","year":"2006","journal-title":"Periodontol 2000"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1902\/annals.1999.4.1.32","article-title":"Periodontitis","volume":"4","author":"Flemmig TF","year":"1999","journal-title":"Ann Periodontol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1902\/jop.2000.71.6.912","article-title":"Evidence for the role of highly leukotoxic Actinobacillus actinomycetemcomitans in the pathogenesis of localized juvenile and other forms of early-onset periodontitis","volume":"71","author":"Haraszthy VI","year":"2000","journal-title":"J Periodontol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1177\/00220345010800062001","article-title":"Early-onset periodontitis in Morocco is associated with the highly leukotoxic clone of Actinobacillus actinomycetemcomitans","volume":"80","author":"Haubek D","year":"2001","journal-title":"J Dent Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1177\/0022034509342190","article-title":"Stability of the JP2 clone of Aggregatibacter actinomycetemcomitans","volume":"88","author":"Haubek D","year":"2009","journal-title":"J Dent Res"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1128\/IAI.01734-06","article-title":"Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans","volume":"75","author":"Haubek D","year":"2007","journal-title":"Infect Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0765.1995.tb01254.x","article-title":"Predominant microflora of severe, moderate and minimal periodontal lesions in young adults with rapidly progressive periodontitis","volume":"30","author":"Kamma JJ","year":"1995","journal-title":"J Periodontal Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1034\/j.1600-051X.1999.260803.x","article-title":"Actinobacillus actinomycetemcomitans in Chinese adults. Serotype distribution and analysis of the leukotoxin gene promoter locus","volume":"26","author":"Mombelli A","year":"1999","journal-title":"J Clin Periodontol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1902\/jop.2000.71.5-S.856","article-title":"Parameter on chronic periodontitis with advanced loss of periodontal support","volume":"71","year":"2000","journal-title":"J Periodontol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1902\/jop.2000.71.5-S.853","article-title":"Parameter on chronic periodontitis with slight to moderate loss of periodontal support","volume":"71","year":"2000","journal-title":"J Periodontol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1590\/S0100-879X2009005000026","article-title":"DNA tests probe the genomic ancestry of Brazilians","volume":"42","author":"Pena SD","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1128\/JCM.41.10.4829-4832.2003","article-title":"Improved PCR for detection of the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans in subgingival plaque samples","volume":"41","author":"Poulsen K","year":"2003","journal-title":"J Clin Microbiol"},{"key":"ref25","first-page":"317","article-title":"Clinical and microbiological studies of children and adolescents receiving orthodontic treatment","volume":"23","author":"Rego RO","year":"2010","journal-title":"Am J Dent"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1590\/S0103-64402007000300008","article-title":"Transmission of Aggregatibacter actinomycetemcomitans between Brazilian women with severe chronic periodontitis and their children","volume":"18","author":"R\u00eago RO","year":"2007","journal-title":"Braz Dent J"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1111\/j.1600-051X.1990.tb00036.x","article-title":"Occurrence of Bacteroides gingivalis, Bacteroides intermedius and Actinobacillus actinomycetemcomitans in severe periodontitis in relation to age and treatment history","volume":"17","author":"Rodenburg JP","year":"1990","journal-title":"J Clin Periodontol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1600-051X.1998.tb02415.x","article-title":"The distribution and transmission of Actinobacillus actinomycetemcomitans in families with localized juvenile periodontitis","volume":"25","author":"Tinoco EM","year":"1998","journal-title":"J Clin Periodontol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0722.1997.tb00246.x","article-title":"Relationship of serotype, leukotoxin gene type and lysogeny in Actinobacillus actinomycetemcomitans to periodontal disease status","volume":"105","author":"Tinoco EM","year":"1997","journal-title":"Eur J Oral Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1902\/annals.1999.4.1.39","article-title":"Early-onset periodontitis","volume":"4","author":"Tonetti MS","year":"1999","journal-title":"Ann Periodontol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1590\/S1678-77572009000500017","article-title":"Occurrence of Aggregatibacter actinomycetemcomitans in Brazilian Indians from Umutina Reservation, Mato Grosso, Brazil","volume":"17","author":"Vieira EM","year":"2009","journal-title":"J Appl Oral Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.diagmicrobio.2012.12.013","article-title":"Phenotypic and genotypic features of Aggregatibacter actinomycetemcomitans isolated from patients with periodontal disease","volume":"75","author":"Wahasugui TC","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1128\/JCM.28.9.1942-1946.1990","article-title":"Amplification of bacterial 16S ribosomal DNA with polymerase chain reaction","volume":"28","author":"Wilson KH","year":"1990","journal-title":"J Clin Microbiol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1600-0757.1995.tb00037.x","article-title":"The laboratory diagnosis of periodontal infections","volume":"7","author":"Zambon JJ","year":"1995","journal-title":"Periodontol 2000"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1902\/jop.1996.67.3s.282","article-title":"The microbiology of early-onset periodontitis: association of highly toxic Actinobacillus actinomycetemcomitans strains with localized juvenile periodontitis","volume":"67","author":"Zambon JJ","year":"1996","journal-title":"J Periodontol"}],"container-title":["Journal of Applied Oral Science"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/jaos\/v21n5\/1678-7757-jaos-21-05-0430.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T15:41:48Z","timestamp":1601739708000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S1678-77572013000500430&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S1678-77572013000500430"],"URL":"https:\/\/doi.org\/10.1590\/1679-775720130252","relation":{},"ISSN":["1678-7757"],"issn-type":[{"value":"1678-7757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}