{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:39:54Z","timestamp":1761129594502,"version":"3.41.2"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"abstract":"<jats:p>ABSTRACT Tuberculosis continues to be a major public health problem worldwide. The aim of the present study was to evaluate the accuracy of the Xpert MTB\/RIF rapid molecular test for tuberculosis, using pulmonary samples obtained from patients treated at the J\u00falia Kubitschek Hospital, which is operated by the Hospital Foundation of the State of Minas Gerais, in the city of Belo Horizonte, Brazil. This was a retrospective study comparing the Xpert MTB\/RIF test results with those of standard culture for Mycobacterium tuberculosis and phenotypic susceptibility tests. Although the Xpert MTB\/RIF test showed high accuracy for the detection of M. tuberculosis and its resistance to rifampin, attention must be given to the clinical status of the patient, in relation to the test results, as well as to the limitations of molecular tests.<\/jats:p>","DOI":"10.1590\/1806-3713\/e20170451","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T19:17:41Z","timestamp":1552159061000},"source":"Crossref","is-referenced-by-count":13,"title":["Accuracy of a rapid molecular test for tuberculosis in sputum samples, bronchoalveolar lavage fluid, and tracheal aspirate obtained from patients with suspected pulmonary tuberculosis at a tertiary referral hospital"],"prefix":"10.1590","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5108-6006","authenticated-orcid":false,"given":"Tatiane Maria da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade da Funda\u00e7\u00e3o Mineira de Educa\u00e7\u00e3o e Cultura,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-0592","authenticated-orcid":false,"given":"Val\u00e9ria Martins","family":"Soares","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hospitalar do Estado de Minas Gerais,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-7857","authenticated-orcid":false,"given":"Mariana Gontijo","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidade da Funda\u00e7\u00e3o Mineira de Educa\u00e7\u00e3o e Cultura,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8109-6777","authenticated-orcid":false,"given":"Adriana dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade da Funda\u00e7\u00e3o Mineira de Educa\u00e7\u00e3o e Cultura,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"year":"2016","series-title":"Global Tuberculosis Report 2016","key":"ref1"},{"issue":"8","key":"ref2","first-page":"1","article-title":"Indicadores priorit\u00e1rios para o monitoramento do Plano Nacional pelo fim da tuberculose como problema de sa\u00fade p\u00fablica no Brasil","volume":"48","year":"2017","journal-title":"Boletim Epidemiol\u00f3gico"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162833","article-title":"Do Xpert MTB\/RIF Cycle Threshold Values Provide Information about Patient Delays for Tuberculosis Diagnosis","volume":"11","author":"Ssengooba W","year":"2016","journal-title":"PLoS One"},{"key":"ref4","first-page":"1","article-title":"MTB\/RIF no diagn\u00f3stico da tuberculose pulmonar","volume":"16","year":"2011","journal-title":"Bol Bras Avalia\u00e7\u00e3o de Tecnologias em 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within the context of the Brazilian Unified Health Care System","volume":"41","author":"Pinto M","year":"2015","journal-title":"J Bras Pneumol"},{"year":"2005","series-title":"Manual de Bacteriologia da Tuberculose","key":"ref12"},{"issue":"1","key":"ref13","first-page":"21","article-title":"Advances in techniques of testing mycobacterial drug sensitivity, and the use of sensitivity tests in tuberculosis control programmes","volume":"41","author":"Canetti G","year":"1969","journal-title":"Bull World Health Organ"},{"issue":"3","key":"ref14","first-page":"173","article-title":"Utilization of bacteriological culture for increased diagnostic performance at a tuberculosis reference center hospital","volume":"44","author":"Martins Soares V","year":"2012","journal-title":"Rev Argent Microbiol"},{"series-title":"Cepheid Xpert MTB\/RIF Brochure","key":"ref15"},{"year":"2015","series-title":"Rede de Teste R\u00e1pido para tuberculose no Brasil: primeiro ano da implanta\u00e7\u00e3o","key":"ref16"},{"key":"ref17","first-page":"18","article-title":"False-positive Xpert(r)MTB\/RIF assays in previously treated patients need for caution in interpreting results","author":"Boyles TH","year":"2014","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref18","first-page":"45","article-title":"Suboptimal specificity of Xpert MTB\/RIF among treatment-experienced patients","author":"Metcalfe JZ","year":"2015","journal-title":"Eur Resp J"},{"key":"ref19","first-page":"48","article-title":"Evaluation of the analytical performance of the Xpert MTB\/RIF assay","author":"Blakemore R","year":"2010","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149258","article-title":"Genotypic, Phenotypic and Clinical Validation of GeneXpert in Extra-Pulmonary and Pulmonary Tuberculosis in India","volume":"11","author":"Singh UB","year":"2016","journal-title":"PLoS One"}],"container-title":["Jornal 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