{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:06Z","timestamp":1787023086399,"version":"build-2736575974"},"reference-count":164,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. bras. pneumol."],"abstract":"<jats:p>ABSTRACT Bronchiectasis is a condition that has been increasingly diagnosed by chest HRCT. In the literature, bronchiectasis is divided into bronchiectasis secondary to cystic fibrosis and bronchiectasis not associated with cystic fibrosis, which is termed non-cystic fibrosis bronchiectasis. Many causes can lead to the development of bronchiectasis, and patients usually have chronic airway symptoms, recurrent infections, and CT abnormalities consistent with the condition. The first international guideline on the diagnosis and treatment of non-cystic fibrosis bronchiectasis was published in 2010. In Brazil, this is the first review document aimed at systematizing the knowledge that has been accumulated on the subject to date. Because there is insufficient evidence on which to base recommendations for various treatment topics, here the decision was made to prepare an expert consensus document. The Brazilian Thoracic Association Committee on Respiratory Infections summoned 10 pulmonologists with expertise in bronchiectasis in Brazil to conduct a critical assessment of the available scientific evidence and international guidelines, as well as to identify aspects that are relevant to the understanding of the heterogeneity of bronchiectasis and to its diagnostic and therapeutic management. Five broad topics were established (pathophysiology, diagnosis, monitoring of stable patients, treatment of stable patients, and management of exacerbations). After this subdivision, the topics were distributed among the authors, who conducted a nonsystematic review of the literature, giving priority to major publications in the specific areas, including original articles, review articles, and systematic reviews. The authors reviewed and commented on all topics, producing a single final document that was approved by consensus.<\/jats:p>","DOI":"10.1590\/1806-3713\/e20190122","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T13:51:37Z","timestamp":1565963497000},"source":"Crossref","is-referenced-by-count":36,"title":["Brazilian consensus on non-cystic fibrosis bronchiectasis"],"prefix":"10.1590","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-4841","authenticated-orcid":false,"given":"M\u00f4nica Corso","family":"Pereira","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9399-5275","authenticated-orcid":false,"given":"Rodrigo Abensur","family":"Athanazio","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-9135","authenticated-orcid":false,"given":"Paulo de Tarso Roth","family":"Dalcin","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brazil; Hospital de Cl\u00ednicas de Porto Alegre,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8711-8957","authenticated-orcid":false,"given":"Mara R\u00fabia Fernandes de","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Hospital de Messejana Dr. Carlos Alberto Studart Gomes,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5165-4501","authenticated-orcid":false,"given":"Mauro","family":"Gomes","sequence":"additional","affiliation":[{"name":"Santa Casa de S\u00e3o Paulo,  Brazil; Hospital Samaritano,  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Zahi","family":"Rached","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-2112","authenticated-orcid":false,"given":"Rosemeri","family":"Maurici","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1164\/ajrccm\/137.4.969","article-title":"Bronchiectasis update of an orphan disease","volume":"137","author":"Barker AF","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"ref2","series-title":"Perfil da morbimortalidade por doen\u00e7as respirato\u00b4rias cr\u00f4nicas no Brasil, 2003 a 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key is in the distribution","volume":"60","author":"Bueno J","year":"2018","journal-title":"Radiologia"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1007\/s00330-016-4286-6","article-title":"Non-tuberculous mycobacterial lung disease diagnosis based on computed tomography of the chest","volume":"26","author":"Kwak N","year":"2016","journal-title":"Eur Radiol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.ccm.2012.02.005","article-title":"Diffuse panbronchiolitis","volume":"33","author":"Kudoh S","year":"2012","journal-title":"Clin Chest Med"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1148\/radiographics.20.3.g00ma01673","article-title":"Aspiration diseases findings, pitfalls, and differential diagnosis","volume":"20","author":"Franquet 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perspectives","volume":"49","author":"Faner R","year":"2017","journal-title":"Eur Respir J"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index An international derivation and validation study","volume":"189","author":"Chalmers JD","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1183\/13993003.01899-2015","article-title":"Clinical phenotypes in adult patients with bronchiectasis","volume":"47","author":"Aliberti S","year":"2016","journal-title":"Eur Respir J"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1513\/AnnalsATS.201706-426OC","article-title":"The Prevalence and Significance of Staphylococcus aureus in Patients with Non-Cystic Fibrosis Bronchiectasis","volume":"15","author":"Metersky ML","year":"2018","journal-title":"Ann Am Thorac Soc"},{"issue":"8","key":"ref62","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1128\/JCM.00764-14","article-title":"Time between collection and storage significantly influences bacterial sequence composition in sputum samples from cystic fibrosis respiratory infections","volume":"52","author":"Cuthbertson L","year":"2014","journal-title":"J Clin Microbiol"},{"key":"ref63","series-title":"Laboratory Standards for Processing Microbiological Samples from People with Cystic Fibrosis","year":"2010"},{"issue":"9484","key":"ref64","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0140-6736(05)67060-2","article-title":"Combination antibiotic susceptibility testing to treat exacerbations of cystic fibrosis associated with multiresistant bacteria a randomised, double-blind, controlled clinical trial","volume":"366","author":"Aaron 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Med"},{"issue":"5","key":"ref68","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1378\/chest.113.5.1329","article-title":"Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I rhDNase Study Group","volume":"113","author":"O'Donnell AE","year":"1998","journal-title":"Chest"},{"issue":"4","key":"ref69","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1164\/ajrccm.162.4.9906120","article-title":"An investigation into causative factors in patients with bronchiectasis","volume":"162","author":"Pasteur MC","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref70","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1183\/09031936.98.12040820","article-title":"Systemic markers of inflammation in stable bronchiectasis","volume":"12","author":"Wilson CB","year":"1998","journal-title":"Eur Respir J"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"9874068","DOI":"10.1155\/2017\/9874068","article-title":"Is There a Correlation between New Scoring Systems and Systemic Inflammation in Stable Bronchiectasis","volume":"2017","author":"Coban H","year":"2017","journal-title":"Can Respir J"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1183\/09031936.00069007","article-title":"Mucosal inflammation in idiopathic bronchiectasis cellular and molecular mechanisms","volume":"31","author":"Fuschillo S","year":"2008","journal-title":"Eur Respir J"},{"issue":"2","key":"ref73","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01953-2017","article-title":"The independent contribution of Pseudomonas aeruginosa infection to long-term clinical outcomes in bronchiectasis","volume":"51","author":"Araujo D","year":"2018","journal-title":"Eur Respir J"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1183\/09031936.00026313","article-title":"Multidimensional approach to non-cystic fibrosis bronchiectasis the FACED score","volume":"43","author":"Mart\u00ednez-Garc\u00eda M\u00c1","year":"2014","journal-title":"Eur Respir J"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/COPD.S121943","article-title":"Predicting high risk of exacerbations in bronchiectasis the E-FACED score","volume":"12","author":"Martinez-Garcia MA","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00139-2017","article-title":"The annual prognostic ability of FACED and E-FACED scores to predict mortality in patients with bronchiectasis","volume":"4","author":"de la Rosa Carrillo D","year":"2018","journal-title":"ERJ Open Res"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/cea.12141","article-title":"Allergic bronchopulmonary aspergillosis review of literature and proposal of new diagnostic and classification criteria","volume":"43","author":"Agarwal R","year":"2013","journal-title":"Clin Exp Allergy"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/ciw326","article-title":"Practice Guidelines for the Diagnosis and Management of Aspergillosis 2016 Update by the Infectious Diseases Society of America","volume":"63","author":"Patterson TF","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"2","key":"ref79","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4046\/trd.2016.79.2.74","article-title":"Diagnosis and Treatment of Nontuberculous Mycobacterial Lung Disease Clinicians' Perspectives","volume":"79","author":"Ryu YJ","year":"2016","journal-title":"Tuberc Respir Dis (Seoul)"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","author":"Griffith DE","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1164\/rccm.201108-1428CI","article-title":"A review of a1-antitrypsin deficiency","volume":"185","author":"Stoller JK","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"issue":"145","key":"ref82","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0023-2017","article-title":"Clinical care for primary ciliary dyskinesia: current challenges and future directions","volume":"26","author":"Rubbo B","year":"2017","journal-title":"Eur Respir Rev"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.jcf.2014.03.010","article-title":"European Cystic Fibrosis Society Standards of Care Best Practice guidelines","volume":"13","author":"Smyth AR","year":"2014","journal-title":"J Cyst Fibros"},{"issue":"4","key":"ref84","doi-asserted-by":"crossref","first-page":"213","DOI":"10.18176\/jiaci.0166","article-title":"Infectious and Noninfectious Pulmonary Complications in Patients With Primary Immunodeficiency Disorders","volume":"27","author":"Yazdani R","year":"2017","journal-title":"J Investig Allergol Clin Immunol"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.arbr.2017.07.014","article-title":"Spanish Guidelines on Treatment of Bronchiectasis in Adults","volume":"54","author":"Mart\u00ednez-Garc\u00eda MA","year":"2018","journal-title":"Arch Bronconeumol"},{"issue":"9","key":"ref86","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archpediatrics.2011.136","article-title":"Comparative efficacy and safety of 4 randomized regimens to treat early Pseudomonas aeruginosa infection in children with cystic fibrosis","volume":"165","author":"Treggiari MM","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"issue":"4","key":"ref87","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/thx.2009.121657","article-title":"Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis the ELITE trial","volume":"65","author":"Ratjen F","year":"2010","journal-title":"Thorax"},{"issue":"4","key":"ref88","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00851-2016","article-title":"Efficacy of Pseudomonas aeruginosa eradication regimens in bronchiectasis","volume":"49","author":"Valli\u00e8res E","year":"2017","journal-title":"Eur Respir J"},{"issue":"3","key":"ref89","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.rmed.2011.11.018","article-title":"Outcomes of Pseudomonas eradication therapy in patients with non-cystic fibrosis bronchiectasis","volume":"106","author":"White L","year":"2012","journal-title":"Respir Med"},{"issue":"6","key":"ref90","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1111\/crj.12278","article-title":"Efficacy and safety of long-term inhaled antibiotic for patients with noncystic fibrosis bronchiectasis a meta-analysis","volume":"10","author":"Yang JW","year":"2016","journal-title":"Clin Respir J"},{"issue":"7","key":"ref91","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1164\/rccm.201507-1449LE","article-title":"Aerosolized Antibiotics for Patients with Bronchiectasis","volume":"193","author":"Nadig TR","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"ref92","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02053-2017","article-title":"RESPIRE 2: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis","volume":"51","author":"Aksamit T","year":"2018","journal-title":"Eur Respir J"},{"issue":"1","key":"ref93","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02052-2017","article-title":"RESPIRE 1: a phase III placebo-controlled randomised trial of ciprofloxacin dry powder for inhalation in non-cystic fibrosis bronchiectasis","volume":"51","author":"De Soyza A","year":"2018","journal-title":"Eur Respir J"},{"key":"ref94","first-page":"A7604.15","article-title":"Inhaled Liposomal Ciprofloxacin in Patients with Bronchiectasis and Chronic Pseudomonas Aeruginosa Infection: Results from Two Parallel Phase III Trials (ORBIT-3 and -4)","volume":"195","author":"Haworth CW","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref95","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1164\/rccm.201005-0756OC","article-title":"A randomized controlled trial of nebulized gentamicin in non-cystic fibrosis bronchiectasis","volume":"183","author":"Murray MP","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"issue":"250","key":"ref96","first-page":"163","article-title":"The response of patients with purulent bronchiectasis to antibiotics for four months","volume":"66","author":"Hill SL","year":"1988","journal-title":"Q J Med"},{"issue":"9842","key":"ref97","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE) a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Wong C","year":"2012","journal-title":"Lancet"},{"issue":"12","key":"ref98","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis the BAT randomized controlled trial","volume":"309","author":"Altenburg J","year":"2013","journal-title":"JAMA"},{"issue":"12","key":"ref99","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.2013.2290","article-title":"Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis the BLESS randomized controlled trial","volume":"309","author":"Serisier DJ","year":"2013","journal-title":"JAMA"},{"issue":"3","key":"ref100","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/resp.12233","article-title":"Long-term macrolides for non-cystic fibrosis bronchiectasis a systematic review and meta-analysis","volume":"19","author":"Wu Q","year":"2014","journal-title":"Respirology"},{"key":"ref101","first-page":"CD012406","article-title":"Macrolide antibiotics for bronchiectasis","volume":"3","author":"Kelly C","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"ref102","article-title":"Macrolide therapy in adults and children with non-cystic fibrosis bronchiectasis a systematic review and meta-analysis","volume":"9","author":"Gao YH","year":"2014","journal-title":"PLoS One"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12879-015-0872-5","article-title":"Effects of long-term use of macrolides in patients with non-cystic fibrosis bronchiectasis a meta-analysis of randomized controlled trials","volume":"15","author":"Fan LC","year":"2015","journal-title":"BMC Infect Dis"},{"issue":"1","key":"ref104","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.pupt.2014.02.002","article-title":"Prolonged treatment with macrolides in adult patients with non-cystic fibrosis bronchiectasis meta-analysis of randomized controlled trials","volume":"29","author":"Zhuo GY","year":"2014","journal-title":"Pulm Pharmacol Ther"},{"issue":"2","key":"ref105","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pupt.2013.09.003","article-title":"Effectiveness and safety of macrolides in bronchiectasis patients a meta-analysis and systematic review","volume":"28","author":"Shi ZL","year":"2014","journal-title":"Pulm Pharmacol Ther"},{"issue":"9","key":"ref106","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1172\/JCI46095","article-title":"Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection","volume":"121","author":"Renna M","year":"2011","journal-title":"J Clin Invest"},{"issue":"10","key":"ref107","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1164\/rccm.201402-0385CI","article-title":"Macrolide antibiotics and the risk of cardiac arrhythmias","volume":"189","author":"Albert RK","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref108","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1370\/afm.1601","article-title":"Azithromycin and levofloxacin use and increased risk of cardiac arrhythmia and death","volume":"12","author":"Rao GA","year":"2014","journal-title":"Ann Fam Med"},{"key":"ref109","first-page":"CD000996","article-title":"Inhaled corticosteroids for bronchiectasis","volume":"5","author":"Kapur N","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"ref110","first-page":"31","article-title":"Bronchiectasis","volume":"9","author":"Nicotra MB","year":"1994","journal-title":"Semin Respir Infect"},{"key":"ref111","first-page":"CD003572","article-title":"Short acting beta-2 agonists for bronchiectasis","volume":"3","author":"Franco F","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"ref112","first-page":"CD002155","article-title":"Long-acting beta-2-agonists for bronchiectasis","volume":"4","author":"Sheikh A","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"ref113","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1378\/chest.11-0180","article-title":"Clinical efficacy and safety of budesonide-formoterol in non-cystic fibrosis bronchiectasis","volume":"141","author":"Martinez-Garc\u00eda MA","year":"2012","journal-title":"Chest"},{"key":"ref114","series-title":"Cochrane Database Syst Rev.","volume-title":"Anticholinergic therapy for bronchiectasis","author":"Lasserson T","year":"2001"},{"issue":"2","key":"ref115","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ccm.2012.02.009","article-title":"Chest physiotherapy techniques in bronchiectasis","volume":"33","author":"Flude LJ","year":"2012","journal-title":"Clin Chest Med"},{"key":"ref116","first-page":"CD008351","article-title":"Airway clearance techniques for bronchiectasis","volume":"5","author":"Lee AL","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"ref117","first-page":"CD011699","article-title":"Positive expiratory pressure therapy versus other airway clearance techniques for bronchiectasis","volume":"9","author":"Lee AL","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"ref118","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5694\/mja14.00287","article-title":"Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand Thoracic Society of Australia and New Zealand guidelines","volume":"202","author":"Chang AB","year":"2015","journal-title":"Med J Aust"},{"issue":"5","key":"ref119","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1164\/rccm.200505-840OE","article-title":"Cystic fibrosis since 1938","volume":"173","author":"Davis PB","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"ref120","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.apmr.2016.05.017","article-title":"Pulmonary Rehabilitation in Individuals With Non-Cystic Fibrosis Bronchiectasis A Systematic Review","volume":"98","author":"Lee AL","year":"2017","journal-title":"Arch Phys Med Rehabil"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1465-9921-15-44","article-title":"The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis--a randomised controlled trial","volume":"15","author":"Lee AL","year":"2014","journal-title":"Respir Res"},{"issue":"6","key":"ref122","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.rppneu.2013.03.006","article-title":"New advances in the therapy of non-cystic fibrosis bronchiectasis","volume":"19","author":"Amorim A","year":"2013","journal-title":"Rev Port Pneumol"},{"issue":"2","key":"ref123","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1177\/039463201302600228","article-title":"Inhaled mucoactive drugs for treating non-cystic fibrosis bronchiectasis in children","volume":"26","author":"Snijders D","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"1","key":"ref124","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.rmed.2004.05.006","article-title":"Evaluation of nebulised hypertonic saline (7%) as an adjunct to physiotherapy in patients with stable bronchiectasis","volume":"99","author":"Kellett F","year":"2005","journal-title":"Respir Med"},{"issue":"12","key":"ref125","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.rmed.2011.07.019","article-title":"Nebulised 7% hypertonic saline improves lung function and quality of life in bronchiectasis","volume":"105","author":"Kellett F","year":"2011","journal-title":"Respir Med"},{"issue":"5","key":"ref126","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.rmed.2011.12.021","article-title":"The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis","volume":"106","author":"Nicolson CH","year":"2012","journal-title":"Respir Med"},{"issue":"12","key":"ref127","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1136\/thoraxjnl-2014-205587","article-title":"Inhaled mannitol for non-cystic fibrosis bronchiectasis a randomised, controlled trial","volume":"69","author":"Bilton D","year":"2014","journal-title":"Thorax"},{"issue":"2","key":"ref128","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.ccm.2012.02.008","article-title":"Pharmacologic agents for mucus clearance in bronchiectasis","volume":"33","author":"Nair GB","year":"2012","journal-title":"Clin Chest Med"},{"issue":"2","key":"ref129","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1164\/ajrccm.154.2.8756815","article-title":"Short-term recombinant human DNase in bronchiectasis Effect on clinical state and in vitro sputum transportability","volume":"154","author":"Wills PJ","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"issue":"6","key":"ref130","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1378\/chest.14-1961","article-title":"The Role of viral infection in pulmonary exacerbations of bronchiectasis in adults a prospective study","volume":"147","author":"Gao YH","year":"2015","journal-title":"Chest"},{"issue":"86","key":"ref131","doi-asserted-by":"crossref","first-page":"20130233","DOI":"10.1098\/rsif.2013.0233","article-title":"Time and dose-dependent risk of pneumococcal pneumonia following influenza a model for within-host interaction between influenza and Streptococcus pneumoniae","volume":"10","author":"Shrestha S","year":"2013","journal-title":"J R Soc Interface"},{"issue":"1","key":"ref132","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jinf.2015.03.009","article-title":"Microbiology and outcomes of community acquired pneumonia in non cystic-fibrosis bronchiectasis patients","volume":"71","author":"Polverino E","year":"2015","journal-title":"J Infect"},{"issue":"1","key":"ref133","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1590\/1806-9282.60.02.004","article-title":"Vaccination in the prevention of infectious respiratory diseases in adults","volume":"60","author":"Lundgren F","year":"2014","journal-title":"Rev Assoc Med Bras (1992)"},{"key":"ref134","series-title":"Pneumologia--Guia de Imuniza\u00e7\u00e3o SBIm\/SBPT","year":"2019"},{"issue":"7","key":"ref135","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.rmed.2007.02.002","article-title":"Analysis of the factors related to mortality in patients with bronchiectasis","volume":"101","author":"Onen ZP","year":"2007","journal-title":"Respir Med"},{"key":"ref136","series-title":"Global Strategy for the Diagnosis, Management, and Prevention of COPD - 2018 Report","year":"2019"},{"issue":"1","key":"ref137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.healun.2014.06.014","article-title":"A consensus document for the selection of lung transplant candidates 2014--an update from the Pulmonary Transplantation Council of the International Society for Heart and Lung Transplantation","volume":"34","author":"Weill D","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"ref138","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1055\/s-0033-1348469","article-title":"Lung transplantation for cystic fibrosis and bronchiectasis","volume":"34","author":"Corris PA","year":"2013","journal-title":"Semin Respir Crit Care Med"},{"issue":"2","key":"ref139","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccm.2012.04.001","article-title":"Pulmonary resection and lung transplantation for bronchiectasis","volume":"33","author":"Mauchley DC","year":"2012","journal-title":"Clin Chest Med"},{"issue":"2","key":"ref140","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1055\/s-0030-1249109","article-title":"Lung transplantation for advanced bronchiectasis","volume":"31","author":"Hayes Jr D","year":"2010","journal-title":"Semin Respir Crit Care Med"},{"issue":"6","key":"ref141","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1590\/s1806-37562015000000100","article-title":"Lung transplantation overall approach regarding its major aspects","volume":"41","author":"Camargo PC","year":"2015","journal-title":"J Bras Pneumol"},{"issue":"10","key":"ref142","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.healun.2004.12.114","article-title":"Lung transplantation for non-cystic fibrosis bronchiectasis analysis of a 13-year experience","volume":"24","author":"Beirne PA","year":"2005","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"ref143","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12890-018-0634-4","article-title":"Outcomes of lung transplantation in adults with bronchiectasis","volume":"18","author":"Birch J","year":"2018","journal-title":"BMC Pulm Med"},{"key":"ref144","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.rmed.2016.04.007","article-title":"Lung transplantation for non-cystic fibrosis bronchiectasis","volume":"115","author":"Rademacher J","year":"2016","journal-title":"Respir Med"},{"key":"ref145","doi-asserted-by":"crossref","first-page":"17382","DOI":"10.1038\/srep17382","article-title":"Efficiency and safety of surgical intervention to patients with Non-Cystic Fibrosis bronchiectasis a meta-analysis","volume":"5","author":"Fan LC","year":"2015","journal-title":"Sci Rep"},{"issue":"3","key":"ref146","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1010-7940(01)00689-3","article-title":"Thoracoscopic lobectomy for benign disease--a single centre study on 64 cases","volume":"20","author":"Weber A","year":"2001","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"ref147","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.athoracsur.2012.01.012","article-title":"Thoracoscopic lobectomy and segmentectomy for infectious lung disease","volume":"93","author":"Mitchell JD","year":"2012","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"ref148","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.athoracsur.2010.08.035","article-title":"Video-assisted thoracic surgery for bronchiectasis","volume":"91","author":"Zhang P","year":"2011","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"ref149","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s00595-009-4013-x","article-title":"Surgical management of bronchiectasis the indications and outcomes","volume":"40","author":"Gursoy S","year":"2010","journal-title":"Surg Today"},{"issue":"2","key":"ref150","first-page":"82","article-title":"Surgical treatment of bronchiectasis A review of 20 years of experience","volume":"22","author":"Coutinho D","year":"2016","journal-title":"Rev Port Pneumol (2006)"},{"issue":"3","key":"ref151","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.athoracsur.2014.04.049","article-title":"Lung resection improves the quality of life of patients with symptomatic bronchiectasis","volume":"98","author":"Vallilo CC","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"ref152","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.athoracsur.2011.08.077","article-title":"Risk factors that affect the surgical outcome in the management of focal bronchiectasis in a developed country","volume":"93","author":"Hiramatsu M","year":"2012","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"ref153","article-title":"Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research","volume":"49","author":"Hill AT","year":"2017","journal-title":"Eur Respir J"},{"issue":"10","key":"ref154","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.201210-1937OC","article-title":"Lung microbiota and bacterial abundance in patients with bronchiectasis when clinically stable and during exacerbation","volume":"187","author":"Tunney MM","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"ref155","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1159\/000489935","article-title":"Cost of Hospitalizations due to Exacerbation in Patients with Non-Cystic Fibrosis Bronchiectasis","volume":"96","author":"de la Rosa Carrillo D","year":"2018","journal-title":"Respiration"},{"issue":"11","key":"ref156","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201711-2202OC","article-title":"Characterization of the \"Frequent Exacerbator Phenotype\" in Bronchiectasis","volume":"197","author":"Chalmers JD","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref157","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4104\/pcrj.2011.00007","article-title":"Primary care summary of the British Thoracic Society Guideline on the management of non-cystic fibrosis bronchiectasis","volume":"20","author":"Hill AT","year":"2011","journal-title":"Prim Care Respir J"},{"issue":"1","key":"ref158","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0974-777X.150885","article-title":"Influence of pseudomonas aeruginosa on exacerbation in patients with bronchiectasis","volume":"7","author":"Chawla K","year":"2015","journal-title":"J Glob Infect 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