{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:13:12Z","timestamp":1777435992009,"version":"3.51.4"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"DOI":"10.1590\/1806-9282.20220166","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:17:15Z","timestamp":1657541835000},"page":"953-957","source":"Crossref","is-referenced-by-count":3,"title":["Continuous clonidine infusion: an alternative for children on mechanical ventilation"],"prefix":"10.1590","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8397-7444","authenticated-orcid":false,"given":"Cinara Carneiro","family":"Neves","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2014-9024","authenticated-orcid":false,"given":"Ver\u00f4nica Indicatti","family":"Fiamenghi","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0134-7845","authenticated-orcid":false,"given":"Patricia Scolari","family":"Fontela","sequence":"additional","affiliation":[{"name":"McGill University,  Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-6239","authenticated-orcid":false,"given":"Jefferson Pedro","family":"Piva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"ref1","series-title":"Sedation and Analgesia","first-page":"7","volume-title":"Analgesia and sedation in hospitalized children. Pediatric Self-Assessment Program, 2017 Book 3","author":"Beckman EJ","year":"2017"},{"issue":"3","key":"ref2","first-page":"270","article-title":"Clonidine in paediatrics: a review","volume":"53","author":"Basker S","year":"2009","journal-title":"Indian J Anaesth"},{"key":"ref3","series-title":"Medicina Intensiva Pedi\u00e1trica","author":"Piva JP","year":"2015","edition":"2\u1d43 ed"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S140","DOI":"10.1002\/jcph.1139","article-title":"Analgesics and sedatives in critically ill newborns and infants: the impact on long-term neurodevelopment","volume":"58","author":"Schiller RM","year":"2018","journal-title":"J Clin Pharmacol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1002\/phar.1850","article-title":"Clonidine for sedation and analgesia and withdrawal in critically Ill infants and children","volume":"36","author":"Capino AC","year":"2016","journal-title":"Pharmacotherapy"},{"issue":"11","key":"ref6","first-page":"1640","article-title":"A descriptive observational study of sedation outcomes and practices in mechanically ventilated children in an Irish PICU to inform future sedative effectiveness research studies","volume":"175","author":"Hayden J","year":"2016","journal-title":"Eur J Pediatr"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s00540-016-2192-3","article-title":"Effects of long-term infusion of sedatives on the cognitive function and expression level of RAGE in hippocampus of rats","volume":"30","author":"Wang J","year":"2016","journal-title":"J Anesth"},{"issue":"1","key":"ref8","first-page":"45","article-title":"Effects of clonidine on withdrawal from long-term dexmedetomidine in the pediatric patient","volume":"20","author":"Lardieri AB","year":"2015","journal-title":"J Pediatr Pharmacol Ther"},{"key":"ref9","first-page":"275","article-title":"Sedation in the pediatric intensive care unit: challenges, outcomes, and future strategies in the United States","author":"Tobias JD","year":"2014","journal-title":"Pediatric Sedation Outside of the Operating Room"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/oxfordjournals.bja.a013594","article-title":"Intravenous clonidine infusion in critically ill children: dose-dependent sedative effects and cardiovascular stability","volume":"84","author":"Ambrose C","year":"2000","journal-title":"Br J Anaesthesia"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/bja\/aeu258","article-title":"Enteral absorption and haemodynamic response of clonidine in infants post-cardiac surgery","volume":"113","author":"Arenas-Lopez S","year":"2014","journal-title":"Br J Anaesth"},{"issue":"4","key":"ref12","first-page":"2157","article-title":"Impact of oral clonidine on duration of opioid and benzodiazepine use in mechanically ventilated children: a randomized, double-blind, placebo-controlled study","volume":"18","author":"Salarian S","year":"2019","journal-title":"Iran J Pharm Res"},{"key":"ref13","first-page":"107","article-title":"Use of continuous infusion of clonidine for sedation in critically ill children: indications, efficacy and side effects","volume":"6","author":"Deho A","year":"2016","journal-title":"Ann Intensive Care"},{"key":"ref14","first-page":"S150","article-title":"Adjunctive clonidine in the sedation of mechanically ventilated children: a pilot randomized trial","volume":"39","author":"Duffett M","year":"2013","journal-title":"Intensive Care Med"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/PCC.0000000000000672","article-title":"Clonidine as a first-line sedative agent after neonatal cardiac surgery","volume":"17","author":"Kleiber N","year":"2016","journal-title":"Pediatr Criti Care Med"},{"issue":"71","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta18710","article-title":"Prospective multicentre randomised, double-blind, equivalence study comparing clonidine and midazolam as intravenous sedative agents in critically ill children: the SLEEPS (safety profile, efficacy and equivalence in paediatric intensive care sedation) study","volume":"18","author":"Wolf A","year":"2014","journal-title":"Health Technol Assess"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/PCC.0000000000000151","article-title":"Continuous infusion of clonidine in ventilated newborns and infants","volume":"15","author":"H\u00fcnseler C","year":"2014","journal-title":"Pediatr Crit Care Med"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1097\/PCC.0000000000001191","article-title":"Validation of the vasoactive-inotropic score in pediatric sepsis","volume":"18","author":"Mcintosh AM","year":"2017","journal-title":"Pediatr Crit Care Med"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/phar.1559","article-title":"Transition from dexmedetomidine to enteral clonidine for ICU Sedation: an observational pilot study","volume":"35","author":"Gagnon DJ","year":"2015","journal-title":"Pharmacotherapy"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/PCC.0000000000000599","article-title":"Efficacy of \u03b12-agonists for sedation in pediatric critical care","volume":"17","author":"Hayden JC","year":"2016","journal-title":"Pediatr Crit Care Med"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"e409","DOI":"10.1097\/PCC.0000000000001602","article-title":"Hemodynamic tolerance to IV clonidine infusion in the PICU","volume":"19","author":"Kleiber N","year":"2018","journal-title":"Pediatr Critical Care"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016031","article-title":"The CLOSED trial; CLOnidine compared with midazolam for SEDation of paediatric patients in the intensive care unit: study protocol for a multicentre randomised controlled trial","volume":"7","author":"Neubert A","year":"2017","journal-title":"BMJ Open"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"e580","DOI":"10.1097\/CCM.0000000000003789","article-title":"The effectiveness of \u03b12 agonists as sedatives in pediatric critical care: a propensity score-matched cohort study","volume":"47","author":"Hayden JC","year":"2019","journal-title":"Crit Care Med"},{"issue":"1-2","key":"ref24","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0014-2999(88)90744-3","article-title":"Characterization of selectivity, specify, and potency of medetomidine as an alpha2-adrenoreceptor agonist","volume":"150","author":"Virtanen R","year":"1998","journal-title":"Eur J Pharmacol"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302022000700953&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,24]],"date-time":"2022-10-24T18:25:46Z","timestamp":1666635946000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302022000700953&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["S0104-42302022000700953"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20220166","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]}}}