{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:13:50Z","timestamp":1784553230092,"version":"3.55.0"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"DOI":"10.1590\/1806-9282.20221730","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T11:58:22Z","timestamp":1689595102000},"source":"Crossref","is-referenced-by-count":1,"title":["The clinical significance of lymphovascular space invasion in patients with low-risk endometrial cancer"],"prefix":"10.1590","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-5298","authenticated-orcid":false,"given":"\u0130lker","family":"\u00c7ak\u0131r","sequence":"first","affiliation":[{"name":"Buca Seyfi Demirsoy Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0779-8305","authenticated-orcid":false,"given":"Varol","family":"G\u00fclseren","sequence":"additional","affiliation":[{"name":"Erciyes University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0145-2976","authenticated-orcid":false,"given":"Emin","family":"B\u00fcy\u00fcktalanc\u0131","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8298-8363","authenticated-orcid":false,"given":"Z\u00fcbeyde Emiralio\u011flu","family":"\u00c7ak\u0131r","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0683-0710","authenticated-orcid":false,"given":"Mehmet","family":"\u00d6zer","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0841-0480","authenticated-orcid":false,"given":"Can","family":"Ata","sequence":"additional","affiliation":[{"name":"Buca Seyfi Demirsoy Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8494-4302","authenticated-orcid":false,"given":"Muzaffer","family":"Sanc\u0131","sequence":"additional","affiliation":[{"name":"Tepecik Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3187-2317","authenticated-orcid":false,"given":"Mehmet","family":"G\u00f6k\u00e7\u00fc","sequence":"additional","affiliation":[{"name":"\u0130zmir University of Economics,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-9070","authenticated-orcid":false,"given":"Sel\u00e7uk","family":"Erk\u0131l\u0131n\u00e7","sequence":"additional","affiliation":[{"name":"Buca Seyfi Demirsoy Education and Research Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2325-1756","authenticated-orcid":false,"given":"Kemal","family":"G\u00fcng\u00f6rd\u00fck","sequence":"additional","affiliation":[{"name":"Mu\u011fla S\u0131tk\u0131 Ko\u00e7man University,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1067\/mob.2000.107335","article-title":"Low-risk corpus cancer: is lymphadenectomy or radiotherapy necessary?","volume":"182","author":"Mariani A","year":"2000","journal-title":"Am J Obstet Gynecol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygyno.2019.04.676","article-title":"Recurrent early stage endometrial cancer: patterns of recurrence and results of salvage therapy","volume":"154","author":"Francis SR","year":"2019","journal-title":"Gynecol Oncol."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1471-0528.2009.02162.x","article-title":"Lymphovascular space involvement in early stage well-differentiated endometrial cancer is associated with increased mortality","volume":"116","author":"O\u2019Brien DJ","year":"2009","journal-title":"BJOG An Int J Obstet Gynaecol."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1136\/ijgc-2020-002230","article-title":"ESGO\/ESTRO\/ESP guidelines for the management of patients with endometrial carcinoma","volume":"31","author":"Concin N","year":"2021","journal-title":"Int J Gynecol Cancer."},{"key":"ref5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijgo.2009.02.012","article-title":"Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium","volume":"105","author":"Pecorelli S","year":"2009","journal-title":"Int J Gynaecol Obstet."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/IGC.0000000000000490","article-title":"Lymphovascular space invasion portends poor prognosis in low-risk endometrial cancer HHS Public access","volume":"25","author":"Dos Reis R","year":"2015","journal-title":"Int J Gynecol Cancer."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1097\/IGC.0000000000001229","article-title":"Prognostic significance of lymphovascular space invasion in the absence of lymph node metastases in early-stage endometrial cancer","volume":"28","author":"Cusano E","year":"2018","journal-title":"Int J Gynecol Cancer."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1159\/000488112","article-title":"Risk factors for recurrence in low-risk endometrial cancer: a case-control study","volume":"41","author":"G\u00fcng\u00f6rd\u00fck K","year":"2018","journal-title":"Oncol Res Treat."},{"key":"ref9","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/ijgc-2018-000069","article-title":"Prognostic significance of lymphovascular space invasion in low-risk endometrial cancer","volume":"29","author":"Ayhan A","year":"2019","journal-title":"Int J Gynecol Cancer."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.3802\/jgo.2019.30.e84","article-title":"Lymph-vascular space invasion (LVSI) as a strong and independent predictor for non-locoregional recurrences in endometrial cancer: a Danish gynecological cancer group study","volume":"30","author":"\u00d8rtoft G","year":"2019","journal-title":"J Gynecol Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00404-019-05418-z","article-title":"Factors predicting recurrence in patients with stage IA endometrioid endometrial cancer: what is the importance of LVSI?","volume":"301","author":"Ureyen I","year":"2020","journal-title":"Arch Gynecol Obstet."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ygyno.2022.11.012","article-title":"Recurrence and survival in endometrioid endometrial cancer - a population-based cohort study","volume":"168","author":"\u00c5kesson \u00c5","year":"2023","journal-title":"Gynecol Oncol."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"808037","DOI":"10.3389\/fmed.2022.808037","article-title":"Risk factors and prognosis of early recurrence in stage I\u2013II endometrial cancer: a large-scale, multi-center, and retrospective study","volume":"9","author":"Dou Y","year":"2022","journal-title":"Front Med"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejca.2020.10.011","article-title":"Semiquantitative evaluation of lymph-vascular space invasion in patients affected by endometrial cancer: prognostic and clinical implications","volume":"142","author":"Restaino S","year":"2021","journal-title":"Eur J Cancer."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ygyno.2021.05.040","article-title":"Absence of prognostic value of lymphovascular space invasion in patients with endometrial cancer and negative sentinel lymph nodes","volume":"162","author":"Matanes E","year":"2021","journal-title":"Gynecol Oncol."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3802\/jgo.2021.32.e11","article-title":"Substantial lymph-vascular space invasion (Lvsi) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer","volume":"32","author":"Tortorella L","year":"2021","journal-title":"J Gynecol Oncol."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ygyno.2016.01.002","article-title":"Magnitude of risk for nodal metastasis associated with lymphvascular space invasion for endometrial cancer","volume":"140","author":"Jorge S","year":"2016","journal-title":"Gynecol Oncol."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"82","DOI":"10.33160\/yam.2022.02.014","article-title":"Is adjuvant chemotherapy necessary in patients with early endometrial cancer?","volume":"65","author":"Iida Y","year":"2022","journal-title":"Yonago Acta Med."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3802\/jgo.2021.32.e22","article-title":"Recurrence risk factors in stage ia grade 1 endometrial cancer","volume":"32","author":"Nwachukwu C","year":"2021","journal-title":"J Gynecol Oncol."}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302023000700610&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T11:58:34Z","timestamp":1689595114000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302023000700610&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":19,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2023]]}},"alternative-id":["S0104-42302023000700610"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20221730","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e20221730"}}