{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:15:28Z","timestamp":1775690128052,"version":"3.50.1"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"5","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"DOI":"10.1590\/1806-9282.20231333","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T10:33:31Z","timestamp":1716201211000},"source":"Crossref","is-referenced-by-count":2,"title":["The effects of leptin and cannabinoid CB1 receptor agonist\/antagonist in cerebral tissues of epileptic rats"],"prefix":"10.1590","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-7809","authenticated-orcid":false,"given":"Mesut","family":"K\u0131l\u0131\u00e7o\u011flu","sequence":"first","affiliation":[{"name":"Kayseri Education and Research Hospital,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7093-1474","authenticated-orcid":false,"given":"U\u011fur","family":"D\u00fcz","sequence":"additional","affiliation":[{"name":"Ayd\u0131n Provincial Directorate of Health,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4186-2478","authenticated-orcid":false,"given":"G\u00f6khan","family":"Arslan","sequence":"additional","affiliation":[{"name":"University of Ondokuz May\u0131s,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6594-3080","authenticated-orcid":false,"given":"Mustafa","family":"Ayy\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"University of Ondokuz May\u0131s,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8450-5791","authenticated-orcid":false,"given":"Erdal","family":"A\u011far","sequence":"additional","affiliation":[{"name":"University of Ondokuz May\u0131s,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1220-7434","authenticated-orcid":false,"given":"Nermin","family":"K\u0131l\u0131\u00e7","sequence":"additional","affiliation":[{"name":"University of Ondokuz May\u0131s,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"dmm047449","DOI":"10.1242\/dmm.047449","article-title":"Modelling epilepsy in the mouse: challenges and solutions","volume":"14","author":"Marshall GF","year":"2021","journal-title":"Dis Model Mech"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1111\/j.1528-1167.2009.02098.x","article-title":"The effects of intracerebroventricular AM-251, a CB1-receptor antagonist, and ACEA, a CB1-receptor agonist, on penicillin-induced epileptiform activity in rats","volume":"50","author":"Kozan R","year":"2009","journal-title":"Epilepsia"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/cns.12075","article-title":"The role of CB1-receptors in the proconvulsant effect of leptin on penicillin-induced epileptiform activity in rats","volume":"19","author":"Arslan G","year":"2013","journal-title":"CNS Neurosci Ther"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"101278","DOI":"10.1016\/j.redox.2019.101278","article-title":"Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy","volume":"26","author":"Shekh-Ahmad T","year":"2019","journal-title":"Redox Biol"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.3390\/antiox10050739","article-title":"The role of NADPH oxidase in neuronal death and neurogenesis after acute neurological disorders","volume":"10","author":"Lee SH","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11154-021-09687-5","article-title":"Leptin as a key regulator of the adipose organ","volume":"23","author":"Pic\u00f3 C","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"679078","DOI":"10.3389\/fnins.2021.679078","article-title":"TRPC1\/5-Ca V 3 complex mediates leptin-induced excitability in hypothalamic neurons","volume":"15","author":"Perissinotti PP","year":"2021","journal-title":"Front Neurosci"},{"issue":"24","key":"ref8","doi-asserted-by":"crossref","first-page":"RC186","DOI":"10.1523\/JNEUROSCI.21-24-j0001.2001","article-title":"Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity","volume":"21","author":"Shanley LJ","year":"2001","journal-title":"J Neurosci"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.neuropharm.2007.08.005","article-title":"Ultra-low dose cannabinoid antagonist AM251 enhances cannabinoid anticonvulsant effects in the pentylenetetrazole-induced seizure in mice","volume":"53","author":"Gholizadeh S","year":"2007","journal-title":"Neuropharmacology"},{"key":"ref10","first-page":"99","article-title":"Rola uk\u0142adu endokannabinoidowego w regulacji czynno\u015bci dokrewnej i Controli r\u00f3wnowagi energetycznej cz\u0142owieka [The role of the endocannabinoid system in the regulation of endocrine function and in the control of energy balance in humans]","volume":"61","author":"Komorowski J","year":"2007","journal-title":"Postepy Hig Med Dosw (Online)"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neulet.2009.07.011","article-title":"The effect of leptin receptor deficiency and fasting on cannabinoid receptor 1 mRNA expression in the rat hypothalamus, brainstem and nodose ganglion","volume":"463","author":"Jelsing J","year":"2009","journal-title":"Neurosci Lett"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.psyneuen.2019.02.004","article-title":"Maternal high-fat diet impairs leptin signaling and up-regulates type-1 cannabinoid receptor with sex-specific epigenetic changes in the hypothalamus of newborn rats","volume":"103","author":"Almeida MM","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry O.H.","year":"1951","journal-title":"J. Biol. Chem"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.maturitas.2008.10.014","article-title":"Estrogen effects on pilocarpine-induced temporal lobe epilepsy in rats","volume":"62","author":"Pereira M","year":"2009","journal-title":"Maturitas"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.peptides.2007.11.020","article-title":"Dose dependent effects of ghrelin on pentylenetetrazole-induced oxidative stress in a rat seizure model","volume":"29","author":"Obay BD","year":"2008","journal-title":"Peptides"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1620\/tjem.206.233","article-title":"Exogenous leptin increases lipid peroxidation in the mouse brain","volume":"206","author":"Kutlu S","year":"2005","journal-title":"Tohoku J Exp Med"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2478\/s11756-007-0148-7","article-title":"The actions of leptin on survival and hydrogen peroxide toxicity in primary mixed glial cells of rat","volume":"62","author":"Kabadere S","year":"2007","journal-title":"Biologia"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/bph.16035","article-title":"Differential regulation of Cav 3.2 and Cav 2.2 calcium channels by CB1 receptors and cannabidiol","volume":"180","author":"Harding EK","year":"2023","journal-title":"Br J Pharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"104675","DOI":"10.1016\/j.neubiorev.2022.104675","article-title":"Neuroplastic alterations in cannabinoid receptors type 1 (CB1) in animal models of epileptic seizures","volume":"137","author":"Lazarini-Lopes W","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"207","DOI":"10.31887\/DCNS.2020.22.3\/blutz","article-title":"Neurobiology of cannabinoid receptor signaling","volume":"22","author":"Lutz B","year":"2020","journal-title":"Dialogues Clin Neurosci"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00424-023-02814-y","article-title":"The electrophysiological and behavioral evaluation of the peptide hemopressin and cannabinoid CB1 receptor agonist and antagonist in pentylenetetrazol model of epilepsy in rats","volume":"475","author":"Al-Kaleel A","year":"2023","journal-title":"Pflugers Arch"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"104204","DOI":"10.1016\/j.micpath.2020.104204","article-title":"Cannabinoid receptors and the proconvulsant effect of toxoplasmosis in mice","volume":"144","author":"Ghanbari MM","year":"2020","journal-title":"Microb Pathog"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"173467","DOI":"10.1016\/j.pbb.2022.173467","article-title":"In vitro and in vivo pharmacology of nine novel synthetic cannabinoid receptor agonists","volume":"220","author":"Marusich JA","year":"2022","journal-title":"Pharmacol Biochem Behav"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.3390\/ijms21103575","article-title":"Antioxidant and neuroprotective effects induced by cannabidiol and cannabigerol in rat CTX-TNA2 astrocytes and isolated cortexes","volume":"21","author":"Giacomo V","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1046\/j.0022-3042.2001.00716.x","article-title":"Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1","volume":"80","author":"Marsicano G","year":"2002","journal-title":"J Neurochem"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302024000500621&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T10:33:43Z","timestamp":1716201223000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302024000500621&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":25,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024]]}},"alternative-id":["S0104-42302024000500621"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20231333","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e20231333"}}