{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T22:15:31Z","timestamp":1770156931667,"version":"3.49.0"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: The aim of this study was to compare the prognostic value of inflammatory indices, including the prognostic nutritional index, advanced lung cancer inflammation index, neutrophil\/lymphocyte ratio, platelet\/lymphocyte ratio, Glasgow Prognostic Score, and C-reactive protein\/albumin ratio, in patients with metastatic non-small cell lung cancer and to determine whether any of the indices are correlated.  METHODS: The demographic, clinicopathological, and laboratory data of 179 patients with metastatic non-small cell lung cancer who presented to our medical oncology clinic between 2014 and 2021 were retrospectively obtained from the hospital database system.  RESULTS: Among the inflammatory indices, C-reactive protein\/albumin ratio (p=0.002), advanced lung cancer inflammation index (p=0.04), and neutrophil\/lymphocyte ratio (p=0.008) were associated with overall survival. Multivariate overall survival analysis showed that Eastern Cooperative Oncology Group Performance Status score (HR 1.37; 95%CI 1.06\u20131.77; p=0.016) and C-reactive protein\/albumin ratio (HR 1.13; 95%CI 1.03\u20131.24; p=0.01) were independent prognostic factors associated with overall survival. Patients with a high and low C-reactive protein\/albumin ratio differed statistically significantly in terms of gender, histopathological subtype, history of smoking, and metastatic site (p&lt;0.05). Correlation analysis showed that C-reactive protein\/albumin ratio was negatively correlated with advanced lung cancer inflammation index (r=-0.433, p&lt;0.001) and positively correlated with the other four indices (neutrophil\/lymphocyte ratio: r=0.368, p&lt;0.001; platelet\/lymphocyte ratio: r=0.321, p&lt;0.001; Glasgow Prognostic Score: r=0.537, p&lt;0.001; and prognostic nutritional index: r=0.223, p=0.003).  CONCLUSION: Our findings show that among the investigated inflammatory indices, C-reactive protein\/albumin ratio has the highest prognostic value in patients with metastatic non-small cell lung cancer.<\/jats:p>","DOI":"10.1590\/1806-9282.20240411","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:05:22Z","timestamp":1748862322000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of inflammatory indices in patients with metastatic non-small cell lung cancer"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3878-988X","authenticated-orcid":false,"given":"Zuhat","family":"Urak\u00e7\u0131","sequence":"first","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7931-2941","authenticated-orcid":false,"given":"Zeynep","family":"Oruc","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8168-136X","authenticated-orcid":false,"given":"Halil","family":"K\u00f6mek","sequence":"additional","affiliation":[{"name":"Gazi Yasargil Training and Research Hospital,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0878-6525","authenticated-orcid":false,"given":"Senar","family":"Ebin\u00e7","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5307-8342","authenticated-orcid":false,"given":"Esra","family":"Pirin\u00e7\u00e7i","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7858-8180","authenticated-orcid":false,"given":"Ziya","family":"Kalkan","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-0341","authenticated-orcid":false,"given":"Bekir","family":"Ta\u015fdemir","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-0524","authenticated-orcid":false,"given":"Muhammet Ali","family":"Kaplan","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-871X","authenticated-orcid":false,"given":"Mehmet","family":"K\u00fc\u00e7\u00fck\u00f6ner","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7451-7286","authenticated-orcid":false,"given":"Abdurrahman","family":"I\u015f\u0131kdo\u011fan","sequence":"additional","affiliation":[{"name":"Dicle University,  T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.chest.2021.12.655","article-title":"Distribution, risk factors, and temporal trends for lung cancer incidence and mortality: a global analysis","volume":"161","author":"Huang J","year":"2022","journal-title":"Chest"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3390\/genes14101906","article-title":"Prognostic factors and markers in non-small cell lung cancer: recent progress and future challenges","volume":"14","author":"Meira DD","year":"2023","journal-title":"Genes (Basel)"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.3390\/cancers15061854","article-title":"Systemic inflammation and lung cancer: is it a real paradigm? Prognostic value of inflammatory indexes in patients with resected non-small-cell lung cancer","volume":"15","author":"Mazzella A","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.31557\/APJCP.2021.22.4.1149","article-title":"Prognostic impact of the advanced lung cancer inflammation index (ALI) in metastatic non-small cell lung cancer treated with first line chemotherapy","volume":"22","author":"Chantharakhit C","year":"2021","journal-title":"Asian Pac J Cancer Prev"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"967","DOI":"10.21037\/apm.2020.04.31","article-title":"The prognostic value of prognostic nutritional index (PNI) and neutrophil to lymphocyte ratio (NLR) for advanced non-small cell lung cancer treated with platinum-based chemotherapeutics","volume":"9","author":"Wang J","year":"2020","journal-title":"Ann Palliat Med"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/ijc.30060","article-title":"Prognostic role of platelet to lymphocyte ratio in non-small cell lung cancers: a meta-analysis including 3,720 patients","volume":"139","author":"Zhao QT","year":"2016","journal-title":"Int J Cancer"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/bjc.2014.145","article-title":"Prognostic performance of inflammation-based prognostic indices in primary operable non-small cell lung cancer","volume":"110","author":"Pinato DJ","year":"2014","journal-title":"Br J Cancer"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/ajco.13055","article-title":"Effect of C-reactive protein\/albumin ratio on prognosis in advanced non-small-cell lung cancer","volume":"14","author":"Ni XF","year":"2018","journal-title":"Asia Pac J Clin Oncol"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.7150\/jca.29319","article-title":"Comparison of the prognostic value of systemic inflammation response markers in small cell lung cancer patients","volume":"10","author":"Zhou T","year":"2019","journal-title":"J Cancer"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1678584","DOI":"10.1155\/2017\/1678584","article-title":"Comparison of inflammation-based prognostic scores in a cohort of patients with resectable esophageal cancer","volume":"2017","author":"Jomrich G","year":"2017","journal-title":"Gastroenterol Res Pract"},{"key":"ref11","first-page":"5525","article-title":"C-reactive protein\/albumin ratio as a predictor of survival of metastatic colorectal cancer patients receiving chemotherapy","volume":"9","author":"Xuefeng Ni PW","year":"2016","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"19523","DOI":"10.1038\/s41598-020-76644-8","article-title":"A comparison of inflammation markers for predicting oncological outcomes after surgical resection of non-small-cell lung cancer: a validated analysis of 2,066 patients","volume":"10","author":"Wu HL","year":"2020","journal-title":"Sci Rep"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1245\/s10434-020-09230-x","article-title":"Identification of the best prognostic marker among immunonutritional parameters using serum C-reactive protein and albumin in non-small cell lung cancer","volume":"28","author":"Matsubara T","year":"2021","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"886","DOI":"10.21037\/tlcr.2019.11.16","article-title":"Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI)","volume":"8","author":"Mandaliya H","year":"2019","journal-title":"Transl Lung Cancer Res"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/ntr\/ntad048","article-title":"Prevalence of nicotine and tobacco product use by sexual identity, gender identity, and sex assigned at birth among emerging adult tobacco users in California, United States","volume":"25","author":"Krueger EA","year":"2023","journal-title":"Nicotine Tob Res"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3892\/or.2012.2123","article-title":"Progression of non-small cell lung cancer: diagnostic and prognostic utility of matrix metalloproteinase-2, C-reactive protein and serum amyloid A","volume":"29","author":"Kanoh Y","year":"2013","journal-title":"Oncol Rep"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/MCO.0b013e32832a7902","article-title":"Systemic inflammation, nutritional status and survival in patients with cancer","volume":"12","author":"McMillan DC","year":"2009","journal-title":"Curr Opin Clin Nutr Metab Care"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025000400601&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T11:05:25Z","timestamp":1748862325000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025000400601&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025000400601"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20240411","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"value":"1806-9282","type":"electronic"},{"value":"0104-4230","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20240411"}}