{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:33:17Z","timestamp":1762342397892,"version":"3.41.2"},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"DOI":"10.1590\/1806-9282.20240534","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T11:56:30Z","timestamp":1727697390000},"source":"Crossref","is-referenced-by-count":1,"title":["Homologous recombination deficiency gene panel analysis results in synchronous endometrial and ovarian cancers"],"prefix":"10.1590","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3910-0821","authenticated-orcid":false,"given":"Ferah","family":"Kazanci","sequence":"first","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9158-220X","authenticated-orcid":false,"given":"Zerrin Y\u0131lmaz","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-4932","authenticated-orcid":false,"given":"Mert","family":"Polat","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6477-0982","authenticated-orcid":false,"given":"Ferhat","family":"Karademir","sequence":"additional","affiliation":[{"name":"Ac\u0131badem University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8396-458X","authenticated-orcid":false,"given":"Ozlem","family":"Erdem","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-9673","authenticated-orcid":false,"given":"Feride \u0130ffet","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Baskent University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-1585","authenticated-orcid":false,"given":"Mehmet Anil","family":"Onan","sequence":"additional","affiliation":[{"name":"Gazi University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2024,10]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ygyno.2018.10.033","article-title":"Risk-based stratification of carcinomas concurrently involving the endometrium and ovary","volume":"152","author":"Turashvili G","year":"2019","journal-title":"Gynecol Oncol"},{"key":"ref2","series-title":"Armed Forces Institute of Pathology;","first-page":"413","volume-title":"Tumors of the ovary and maldeveloped gonads.","author":"Scully RE","year":"1979"},{"key":"ref3","series-title":"WHO classification of tumours of female reproductive organs","first-page":"316","author":"Kurman RJ","year":"2014","edition":"4th"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"djv427","DOI":"10.1093\/jnci\/djv427","article-title":"Massively parallel sequencing-based clonality analysis of synchronous endometrioid endometrial and ovarian carcinomas","volume":"108","author":"Schultheis AM","year":"2016","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"djv428","DOI":"10.1093\/jnci\/djv428","article-title":"Synchronous endometrial and ovarian carcinomas: evidence of clonality","volume":"108","author":"Anglesio MS","year":"2016","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/ijc.32907","article-title":"Molecular profiling identifies synchronous endometrial and ovarian cancers as metastatic endometrial cancer with favorable clinical outcome","volume":"147","author":"Reijnen C","year":"2020","journal-title":"Int J Cancer"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1097\/IGC.0000000000001227","article-title":"Combination of scoring criteria and whole exome sequencing analysis of synchronous endometrial and ovarian carcinomas","volume":"28","author":"Yang L","year":"2018","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.3802\/jgo.2019.30.e7","article-title":"Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma","volume":"30","author":"Yoneoka Y","year":"2019","journal-title":"J Gynecol Oncol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3390\/jpm13020284","article-title":"Homologous recombination deficiency in ovarian cancer: from the biological rationale to current diagnostic approaches","volume":"13","author":"Mangogna A","year":"2023","journal-title":"J Pers Med"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jmoldx.2022.09.004","article-title":"Homologous recombination deficiency as an ovarian cancer biomarker in a real-world cohort: validation of decentralized genomic profiling","volume":"24","author":"Denkert C","year":"2022","journal-title":"J Mol Diagn"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1136\/ijgc-2022-004211","article-title":"Homologous recombination deficiency in newly diagnosed FIGO stage III\/IV high-grade epithelial ovarian cancer: a multi-national observational study","volume":"33","author":"Morgan RD","year":"2023","journal-title":"Int J Gynecol Cancer"},{"key":"ref12","series-title":"Presented at: ESMO Gynaecological Cancers Congress 2023;","first-page":"23","volume-title":"Homologous recombination deficiency gene mutations in uterine serous cancer.","author":"Ahsan MD","year":"2023"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1078-0432.CCR-18-1443","article-title":"Frequent homologous recombination deficiency in high-grade endometrial carcinomas","volume":"25","author":"Jonge MM","year":"2019","journal-title":"Clin Cancer Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.humpath.2018.11.001","article-title":"High frequency of POLE mutations in synchronous endometrial and ovarian carcinoma","volume":"85","author":"Ishikawa M","year":"2019","journal-title":"Hum Pathol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ygyno.2016.07.114","article-title":"Implication of genomic characterization in synchronous endometrial and ovarian cancers of endometrioid histology","volume":"143","author":"Chao A","year":"2016","journal-title":"Gynecol Oncol"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/modpathol.2013.107","article-title":"Ovarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles","volume":"27","author":"McConechy MK","year":"2014","journal-title":"Mod Pathol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/his.12543","article-title":"Ovarian and endometrial endometrioid adenocarcinomas have distinct profiles of microsatellite instability, PTEN expression, and ARID1A expression","volume":"66","author":"Huang HN","year":"2015","journal-title":"Histopathology"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s00109-021-02064-4","article-title":"Molecular evidence for a clonal relationship between synchronous uterine endometrioid carcinoma and ovarian clear cell carcinoma: a new example of \u201cprecursor escape\u201d?","volume":"99","author":"Weng CH","year":"2021","journal-title":"J Mol Med (Berl)"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ygyno.2018.11.033","article-title":"The fallopian tube, \u201cprecursor escape\u201d and narrowing the knowledge gap to the origins of high-grade serous carcinoma","volume":"152","author":"Soong TR","year":"2019","journal-title":"Gynecol Oncol"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"153032","DOI":"10.1016\/j.prp.2020.153032","article-title":"ATM mutations as an independent prognostic factor and potential biomarker for immune checkpoint therapy in endometrial cancer","volume":"216","author":"Sun L","year":"2020","journal-title":"Pathol Res Pract"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302024001000603&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T11:56:36Z","timestamp":1727697396000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302024001000603&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":20,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["S0104-42302024001000603"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20240534","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2024,10]]},"article-number":"e20240534"}}