{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:43:02Z","timestamp":1792683782242,"version":"4.5.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: In some diseases associated with inflammation, the C-reactive protein-to-albumin ratio can be used as a biomarker of inflammation. Since lichen planus is a chronic inflammatory disease, our study aimed to investigate the relationship between C-reactive protein-to-albumin ratio and disease activity and whether it plays a role in determining disease prognosis, and compare them with those in subjects without lichen planus.  METHODS: This is a case\u2013control study. Demographic data, clinical features, and laboratory measures, including neutrophil, lymphocyte, eosinophil, platelet counts, neutrophile-to-lymphocyte ratio, erythrocyte sedimentation rate, C-reactive protein, albumin, and C-reactive protein-to-albumin ratio were statistically compared between patients with lichen planus (n=61) and controls (n=64).  RESULTS: Albumin and erythrocyte sedimentation rate (p&lt;0.001), C-reactive protein (p=0.017), C-reactive protein-to-albumin ratio (p=0.016), and neutrophile-to-lymphocyte ratio (p=0.02) were significantly higher in the patient group than in the control group. C-reactive protein-to-albumin ratio (p=0.003, OR 1.2), neutrophile-to-lymphocyte ratio (p=0.02, OR 1.4), and erythrocyte sedimentation rate (p=0.003, OR 1.1) were effective in differentiating patients from the healthy group. Erythrocyte sedimentation rate&gt;4.5 mm\/h, C-reactive protein-to-albumin ratio&gt;0.6, and neutrophile-to-lymphocyte ratio&gt;1 were useful in showing disease activity, of which C-reactive protein-to-albumin ratio has the best value with 92% sensitivity. C-reactive protein-to-albumin ratio has a sensitivity of 100% and is more effective and sensitive than other markers in distinguishing between mild and severe groups and between single and multiple involvement.  CONCLUSION: Elevated C-reactive protein-to-albumin ratio levels may be considered a potential marker for lichen planus. It may be highly sensitive to follow-up of systemic inflammation and disease activity in patients with lichen planus. However, further prospective studies may confirm the association between C-reactive protein-to-albumin ratio and lichen planus.<\/jats:p>","DOI":"10.1590\/1806-9282.20241166","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T04:40:23Z","timestamp":1743568823000},"source":"Crossref","is-referenced-by-count":5,"title":["The association of C-reactive protein to albumin ratio w\u0131th lichen planus"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3074-5989","authenticated-orcid":false,"given":"Hatice","family":"Ata\u015f","sequence":"first","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6068-7444","authenticated-orcid":false,"given":"Tu\u011fba","family":"Atak","sequence":"additional","affiliation":[{"name":"Ministry of Health Islahiye State Hospital,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-8635","authenticated-orcid":false,"given":"Selda Pelin","family":"Kartal","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-1531","authenticated-orcid":false,"given":"Gamze","family":"Tas Aygar","sequence":"additional","affiliation":[{"name":"University of Health Sciences,  Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"737813","DOI":"10.3389\/fmed.2021.737813","article-title":"Lichen planus","volume":"8","author":"Boch K","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.12659\/MSM.912495","article-title":"The C-reactive 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