{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T07:57:54Z","timestamp":1767772674355,"version":"3.41.2"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Assoc. Med. Bras."],"abstract":"<jats:p>SUMMARY  OBJECTIVE: Pelvic inflammatory disease is one of the most common gynecological diseases, and 15% of cases are accompanied by tubal-ovarian abscesses. The aim of this study was to evaluate the usefulness of abscess mass size, serum procalcitonin, and other biochemical markers in patients with tubo-ovarian abscesses in predicting surgical intervention.  METHODS: This case\u2013control study included 113 women who were diagnosed with tubo-ovarian abscess, hospitalized, and started on antibiotic treatment. Demographic characteristics, biochemical markers, ultrasound findings, and length of hospital stay were recorded during medical treatment.  RESULT: In terms of demographic characteristics, there was no significant difference between cases requiring complete recovery with medical treatment and cases requiring surgery for complete recovery. While serum cancer antigen 125 level was not statistically significant, there was a significant difference among biochemical markers: serum white blood cell level (18,007.0\u00b16,406.3; p=0.001), C-reactive protein level (261.2\u00b1122.2; p&lt;0.001), procalcitonin level (0.88\u00b10.46; p&lt;0.001), and abscess mass size (6.1\u00b11.2; p&lt;0.001) in cases that required surgery for full recovery. The highest sensitivity variable predicting surgical intervention in tubo-ovarian abscess patients was abscess mass size (cut-off value&gt;5.25 cm and area under the curve 0.768) with a sensitivity of 72.2%. The second highest sensitivity variant, procalcitonin (cut-off value&gt;0.635 ng\/mL and area under the curve 0.756), showed a sensitivity of 70.4%.  CONCLUSION: Although procalcitonin provides information about the severity of the disease in patients with tubo-ovarian abscesses, evaluation of the abscess mass size along with its size was useful in deciding surgical intervention.<\/jats:p>","DOI":"10.1590\/1806-9282.20241294","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:09:42Z","timestamp":1746184182000},"source":"Crossref","is-referenced-by-count":1,"title":["The usefulness of serum procalcitonin levels in predicting surgical intervention in patients with tubo-ovarian abscess"],"prefix":"10.1590","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2188-2503","authenticated-orcid":false,"given":"Osman Samet","family":"Gunkaya","sequence":"first","affiliation":[{"name":"University of Health Sciences Turkey,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-6400","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl","family":"Bestel","sequence":"additional","affiliation":[{"name":"University of Health Sciences Turkey,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00404-020-05640-0","article-title":"Retrospective study on the efficacy and prognostic factors of conservative versus drainage of tubo-ovarian abscesses","volume":"302","author":"Wong TTC","year":"2020","journal-title":"Arch Gynecol Obstet"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1136\/sti.2005.019539","article-title":"Risk factors associated with pelvic inflammatory disease","volume":"82","author":"Simms I","year":"2006","journal-title":"Sex Transm Infect"},{"issue":"1-2","key":"ref3","first-page":"26","article-title":"Effects of levonorgestrel intrauterine system on patients with female sexual dysfunction","volume":"62","author":"Ulubay M","year":"2017","journal-title":"J Reprod Med"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijgo.2016.04.006","article-title":"The value of ultrasonographic tubo-ovarian abscess morphology in predicting whether patients will require surgical treatment","volume":"135","author":"Kinay T","year":"2016","journal-title":"Int J Gynaecol Obstet"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000358393","article-title":"Pelvic inflammatory disease: a retrospective clinical analysis of 1,922 cases in North China","volume":"77","author":"Zhao WH","year":"2014","journal-title":"Gynecol Obstet Invest"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jmig.2019.04.027","article-title":"Can the need for invasive intervention in tubo-ovarian abscess be predicted? The implication of C-reactive protein measurements","volume":"27","author":"Ribak R","year":"2020","journal-title":"J Minim Invasive Gynecol"},{"issue":"5","key":"ref7","first-page":"350","article-title":"Which treatment should we choose for tubo-ovarian abscesses? Results of an 8-year clinical training in a tertiary center","volume":"95","author":"Bestel A","year":"2024","journal-title":"Ginekol Pol"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.5152\/jtgga.2015.15123","article-title":"The evaluation of risk factors for failed response to conservative treatment in tubo-ovarian abscesses","volume":"16","author":"Akkurt M\u00d6","year":"2015","journal-title":"J Turk Ger Gynecol Assoc"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1159\/000449161","article-title":"Usefulness of serum procalcitonin levels in predicting tubo-ovarian abscess in patients with acute pelvic inflammatory disease","volume":"82","author":"Erenel H","year":"2017","journal-title":"Gynecol Obstet Invest"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually Transmitted Infections Treatment Guidelines, 2021","volume":"70","author":"Workowski KA","year":"2021","journal-title":"MMWR Recomm Rep"},{"issue":"2","key":"ref11","first-page":"228","article-title":"Reproductive outcomes of patients being hospitalised with pelvic inflammatory disease","volume":"37","author":"Chayachinda C","year":"2017","journal-title":"J Obstet Gynaecol"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1080\/01443615.2020.1821620","article-title":"Impact of early surgical management on tubo-ovarian abscesses","volume":"41","author":"Zhu S","year":"2021","journal-title":"J Obstet Gynaecol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejogrb.2019.05.004","article-title":"The predictive role of CA-125 in the management of tubo-ovarian abscess. 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Factors associated with operative intervention after failed antibiotic therapy","volume":"58","author":"Greenstein Y","year":"2013","journal-title":"J Reprod Med"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00404-024-07453-x","article-title":"Evaluation of systemic immune-inflammation index for predicting late-onset fetal growth restriction","volume":"310","author":"Firatligil FB","year":"2024","journal-title":"Arch Gynecol Obstet"}],"container-title":["Revista da Associa\u00e7\u00e3o M\u00e9dica Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0104-42302025000300608&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:09:45Z","timestamp":1746184185000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0104-42302025000300608&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"alternative-id":["S0104-42302025000300608"],"URL":"https:\/\/doi.org\/10.1590\/1806-9282.20241294","relation":{},"ISSN":["1806-9282","0104-4230"],"issn-type":[{"type":"electronic","value":"1806-9282"},{"type":"print","value":"0104-4230"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e20241294"}}